Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması

Year 2022, Volume: 3 Issue: 1, 58 - 66, 30.06.2022

Duried Alvazeer , Sümeyra Al , Mehmet Hakkı Alma

Abstract

COVID-19 (Corona Virüs Hastalığı 2019), SARS-CoV-2 suşunun neden olduğu ciddi ve akut ‎solunum sendromu hastalığıdır. İlk COVID-19 vakası Aralık 2019'da ortaya çıkmış ve aylar ‎içinde tüm dünyada görülen salgın haline gelmiştir. Moleküler hidrojen (H2); reaktif oksijen ‎türlerini seçici olarak süpürmesi, inflamatuar sitokinlerin inaktivasyonu, antiapoptotik ‎özelliği sayesinde birçok hastalık üzerinde etkili bir tedavi yöntemi olarak kullanılmaktadır. ‎Özellikle inflamatuar akciğer yaralanmaları tedavisinde H2’nin terapötik etkileri, COVID-19 ‎hastalığını hafifletebileceği görüşünü desteklemektedir. Aynı zamanda, H2 erken aşamada ‎COVID-19 sırasında SARS-CoV-2'nin neden olduğu yıkıcı sitokin fırtınasını ve akciğer ‎hasarını azaltabilir. Bu nedenle moleküler hidrojen tedavisi, COVID-19 için yeni ve etkili bir ‎tedavi yöntemi olma potansiyeline sahiptir. Fakat bu hipotezin doğrulanması için daha fazla ‎klinik denemelere ihtiyaç vardır.‎

Keywords

COVID-19, Oksi-Hidrojen, Moleküler hidrojen, SARS-CoV-2‎, Sitokin fırtınası

Thanks

Projeye katkılarından dolayı Epoch (Tayvan) firmasına teşekkür ederiz.‎

References

• Alwazeer, D. Potential Cheap and effective Drug for COVID-19 ‎https://www.researchgate.net/post/Potential_Cheap_and_effective_Drug_for_COVID-19 ‎‎(accessed June 26, 2021).‎
• Alwazeer, D. and Al, S. (2021). Moleküler Hidrojenin Sağlık Alanında Kullanımı. Karya ‎Journal of Health Science. (Yayın sürecinde)‎
• Cabler, S., et al. (2020). "A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-‎Associated Cytokine Storm Syndromes." Trends in Molecular Medicine.‎
• Cejka, C., et al. (2020). "An Immunohistochemical Study of the Increase in Antioxidant ‎Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of ‎Alkali-Induced Oxidative Stress." Oxid Med Cell Longev 2020: 7435260.‎
• Chen, N., et al. (2020). "Epidemiological and clinical characteristics of 99 cases of 2019 ‎novel coronavirus pneumonia in Wuhan, China: a descriptive study." The lancet 395(10223): ‎‎507-513.‎
• Conti, P., et al. (2020). "Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung ‎inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies." ‎J Biol Regul Homeost Agents 34(2): 1.‎
• Farooqi, F., et al. (2020). "Treatment of severe COVID-19 with tocilizumab mitigates ‎cytokine storm and averts mechanical ventilation during acute respiratory distress: a case ‎report and literature review." Trop Med Infect Dis 5(3): 112.‎
• Guan, W.-J., et al. (2020). "Hydrogen/oxygen mixed gas inhalation improves disease severity ‎and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label ‎clinical trial." J Thorac Dis 12(6): 3448.‎
• Iketani, M. and I. Ohsawa (2017). "Molecular hydrogen as a neuroprotective agent." Current ‎neuropharmacology 15(2): 324-331.‎
• LeBaron, T., et al. (2020). "A novel functional beverage for COVID-19 and other conditions: ‎hypothesis and preliminary data, increased blood flow, and wound healing." J Transl Sci 6: ‎‎1-6.‎
• Liu, Y., et al. (2020). "The reproductive number of COVID-19 is higher compared to SARS ‎coronavirus." Journal of travel medicine.‎
• Menshchikova, E., et al. (2013). "Oxidative stress and free-radical oxidation in bcg ‎granulomatosis development." Oxid Med Cell Longev 2013.‎
• Ohsawa, I., et al. (2007). "Hydrogen acts as a therapeutic antioxidant by selectively reducing ‎cytotoxic oxygen radicals." Nat Med 13(6): 688-694.‎
• Ohta, S. (2015). "Molecular hydrogen as a novel antioxidant: overview of the advantages of ‎hydrogen for medical applications." Methods Enzymol 555: 289-317.‎
• Rothan, H. A. and S. N. Byrareddy (2020). "The epidemiology and pathogenesis of ‎coronavirus disease (COVID-19) outbreak." Journal of autoimmunity 109: 102433.‎
• Russell, G., et al. "Oxy-hydrogen Gas: The Rationale Behind Its Use as a Novel and ‎Sustainable Treatment for COVID-19 and Other Respiratory Diseases."‎
• Russell, G., et al. (2020). "An overview of SARS-CoV-2 (COVID-19) infection and the ‎importance of molecular hydrogen as an adjunctive therapy." Reactive Oxygen Species ‎‎10(28): 150–165-150–165.‎
• Sawalha, A. H., et al. (2020). "Epigenetic dysregulation of ACE2 and interferon-regulated ‎genes might suggest increased COVID-19 susceptibility and severity in lupus patients." ‎Clinical Immunology 215: 108410.‎
• Wang, M., et al. (2021). "Hydrogen therapy as an effective and novel adjuvant treatment ‎against COVID-19." QJM: An International Journal of Medicine 114(1): 74-75.‎
• Wang, S.-T., et al. (2020). "Hydrogen gas (XEN) inhalation ameliorates airway ‎inflammation in asthma and COPD patients." QJM: An International Journal of Medicine ‎‎113(12): 870-875.‎
• Xiao, M., et al. (2013). "Hydrogen-rich saline reduces airway remodeling via inactivation of ‎NF-kappaB in a murine model of asthma." Eur Rev Med Pharmacol Sci 17(8): 1033-1043.‎
• Xu, K. (2020). Hydrogen-oxygen Inhalation For Treatment Of Covid-19, World Scientific.‎
• Yang, F., et al. (2020). "Hydrogen: a potential new adjuvant therapy for COVID-19 patients." ‎Front Pharmacol 11: 1420.‎
• Yang, Y., et al. (2012). "Hydrogen-rich saline protects immunocytes from radiation-induced ‎apoptosis." Medical science monitor: international medical journal of experimental and ‎clinical research 18(4): BR144.‎
• Yuan, J., et al. (2018). "Hydrogen-rich water attenuates oxidative stress in rats with ‎traumatic brain injury via Nrf2 pathway." Journal of Surgical Research 228: 238-246.‎
• Zolotarenko, A. D., et al. (2021). "The use of ultrapure molecular hydrogen enriched with ‎atomic hydrogen in apparatuses of artificial lung ventilation in the fight against virus ‎COVID-19." International Journal of Hydrogen Energy.‎