Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun Potansiyel Uygulaması
Yıl 2022,
Cilt: 3 Sayı: 1, 58 - 66, 30.06.2022
Duried Alvazeer
,
Sümeyra Al
,
Mehmet Hakkı Alma
Öz
COVID-19 (Corona Virüs Hastalığı 2019), SARS-CoV-2 suşunun neden olduğu ciddi ve akut solunum sendromu hastalığıdır. İlk COVID-19 vakası Aralık 2019'da ortaya çıkmış ve aylar içinde tüm dünyada görülen salgın haline gelmiştir. Moleküler hidrojen (H2); reaktif oksijen türlerini seçici olarak süpürmesi, inflamatuar sitokinlerin inaktivasyonu, antiapoptotik özelliği sayesinde birçok hastalık üzerinde etkili bir tedavi yöntemi olarak kullanılmaktadır. Özellikle inflamatuar akciğer yaralanmaları tedavisinde H2’nin terapötik etkileri, COVID-19 hastalığını hafifletebileceği görüşünü desteklemektedir. Aynı zamanda, H2 erken aşamada COVID-19 sırasında SARS-CoV-2'nin neden olduğu yıkıcı sitokin fırtınasını ve akciğer hasarını azaltabilir. Bu nedenle moleküler hidrojen tedavisi, COVID-19 için yeni ve etkili bir tedavi yöntemi olma potansiyeline sahiptir. Fakat bu hipotezin doğrulanması için daha fazla klinik denemelere ihtiyaç vardır.
Teşekkür
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Kaynakça
- Alwazeer, D. Potential Cheap and effective Drug for COVID-19 https://www.researchgate.net/post/Potential_Cheap_and_effective_Drug_for_COVID-19 (accessed June 26, 2021).
- Alwazeer, D. and Al, S. (2021). Moleküler Hidrojenin Sağlık Alanında Kullanımı. Karya Journal of Health Science. (Yayın sürecinde)
- Cabler, S., et al. (2020). "A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes." Trends in Molecular Medicine.
- Cejka, C., et al. (2020). "An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress." Oxid Med Cell Longev 2020: 7435260.
- Chen, N., et al. (2020). "Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study." The lancet 395(10223): 507-513.
- Conti, P., et al. (2020). "Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies." J Biol Regul Homeost Agents 34(2): 1.
- Farooqi, F., et al. (2020). "Treatment of severe COVID-19 with tocilizumab mitigates cytokine storm and averts mechanical ventilation during acute respiratory distress: a case report and literature review." Trop Med Infect Dis 5(3): 112.
- Guan, W.-J., et al. (2020). "Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial." J Thorac Dis 12(6): 3448.
- Iketani, M. and I. Ohsawa (2017). "Molecular hydrogen as a neuroprotective agent." Current neuropharmacology 15(2): 324-331.
- LeBaron, T., et al. (2020). "A novel functional beverage for COVID-19 and other conditions: hypothesis and preliminary data, increased blood flow, and wound healing." J Transl Sci 6: 1-6.
- Liu, Y., et al. (2020). "The reproductive number of COVID-19 is higher compared to SARS coronavirus." Journal of travel medicine.
- Menshchikova, E., et al. (2013). "Oxidative stress and free-radical oxidation in bcg granulomatosis development." Oxid Med Cell Longev 2013.
- Ohsawa, I., et al. (2007). "Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals." Nat Med 13(6): 688-694.
- Ohta, S. (2015). "Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications." Methods Enzymol 555: 289-317.
- Rothan, H. A. and S. N. Byrareddy (2020). "The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak." Journal of autoimmunity 109: 102433.
- Russell, G., et al. "Oxy-hydrogen Gas: The Rationale Behind Its Use as a Novel and Sustainable Treatment for COVID-19 and Other Respiratory Diseases."
- Russell, G., et al. (2020). "An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy." Reactive Oxygen Species 10(28): 150–165-150–165.
- Sawalha, A. H., et al. (2020). "Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients." Clinical Immunology 215: 108410.
- Wang, M., et al. (2021). "Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19." QJM: An International Journal of Medicine 114(1): 74-75.
- Wang, S.-T., et al. (2020). "Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients." QJM: An International Journal of Medicine 113(12): 870-875.
- Xiao, M., et al. (2013). "Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma." Eur Rev Med Pharmacol Sci 17(8): 1033-1043.
- Xu, K. (2020). Hydrogen-oxygen Inhalation For Treatment Of Covid-19, World Scientific.
- Yang, F., et al. (2020). "Hydrogen: a potential new adjuvant therapy for COVID-19 patients." Front Pharmacol 11: 1420.
- Yang, Y., et al. (2012). "Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis." Medical science monitor: international medical journal of experimental and clinical research 18(4): BR144.
- Yuan, J., et al. (2018). "Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway." Journal of Surgical Research 228: 238-246.
- Zolotarenko, A. D., et al. (2021). "The use of ultrapure molecular hydrogen enriched with atomic hydrogen in apparatuses of artificial lung ventilation in the fight against virus COVID-19." International Journal of Hydrogen Energy.