Effects of Probiotics on Colon Microbiota: Recent Studies

Abstract

In recent years, increasing in health problems parallel to use of antibiotics, required to investigate novel solutions. As a result of increased indust- rial production, healthy novel products started to gain importance as alternative to widely available low-quality food products. Probiotic foods became prominent within these groups of products under favour of providing many advantages. In addition, the importance of gut microbiota started to be understood better in parallel with scientific developments within last 15 years. As its importance was noticed throughout this year in the COVID-19 pandemic, the variety of bacteria in the colon can have decisive effects on human health and quality of life. The character of the colon microbiota, which is thought to be in a close relationship with nutrition, has been associated with the exposure degree of people to various diseases in some studies. In this study, effects of probiotics on gut microbiota investigated and for this purpose, recent publications related with this topic reviewed.

Keywords

• Microbiota
• probiotic foods
• nutrition
• gastrointestinal system
• health

Probiyotiklerin Kolon Mikrobiyotasına Etkileri: Güncel Çalışmalar

Abstract

Son yıllarda yükselen antibiyotik kullanımına paralel olarak artan sağlık sorunları, beraberinde yeni çözümlerin araştırılması gerekliliğini ortaya çıkarmıştır. Artan sanayi üretimi ile beraber yaygınlaşan niteliği düşük gıda ürünlerine alternatif olarak sağlıklı yeni ürünler önem kazanmaya başlamıştır. Probiyotik gıdalar bu ürün grupları içerisinde sağladıkları pek çok avantajlar sayesinde öne çıkmıştır. Buna paralel olarak, kolon mikrobiyotasının önemi son 15 sene içerisinde yaşanan bilimsel gelişmelere paralel olarak daha iyi bir şekilde anlaşılmaya başlanmıştır. Bu yıl yaşanan COVID-19 pandemisinde de önemi farkedildiği gibi kolonda yer alan bakteri çeşitliliği insan sağlığı ve yaşam kalitesi üzerinde belirleyeci etkilere sahip olabilmektedir. Beslenme ile yakın bir ilişki içerisinde olduğu düşünülen kolon mikrobiyotasının niteliği, yapılan bazı çalışmalarda insanların çeşitli hastalıklara maruz kalma durumları ile ilişkilendirilmiştir. Yapılan bu çalışmada, probiyotik gıdaların kolon mikrobiyotası üzerinde neden olduğu çeşitli etkiler ele alınarak, konu hakkında yapılan güncel çalışmalar derlenmiştir.

Keywords

• Mikrobiyota
• probiyotik gıdalar
• beslenme,
• sindirim sistemi
• sağlık

References

1. 1. Khalesi S, Bellissimo N, Vandelanotte C, Williams S, Stanley D, Irwin C. A review of probiotic supplementation in healthy adults: Helpful or hype? Eur J Clin Nutr. 2019;73(1):24-37. doi:https://doi.org/10.1038/s41430-018-0135-9
2. 2. Korkut AY, Hoşsu B, Ferhatoğlu M. (2003). Probiyotikler ve su ürünlerinde kullanımı. Ege Üniversitesi Su Ürün Dergisi. 2003;20(3-4):551-556.
3. 3. Güzel-Seydim ZB. Fonksiyonel Beslenme. (1. Baskı). Sidas Yayınları, İzmir, 2016.
4. 4. Gülbandılar A, Okur M, Dönmez M. Fonksiyonel Gıda Olarak Kullanılan Probiyotikler ve Özellikleri. Türk Bilimsel Derlemeler Dergisi. 2017;10(1):44-47.
5. 5. Kveylis P, Pissaridi K, Bekatorou A, Kanellaki M, Koutinas AA. Dairy ve non-dairy probiotic beverages. Curr Opin Food Sci. 2016;7:58-63. doi:https://doi.org/10.1016/j.cofs.2015.11.012
6. 6. Prado, FC, Parada JL, Pveey A, Soccol CR. Trends in non-dairy probiotic beverages. Food Res Int. 2008;41(2):111-123. doi:https://doi.org/10.1016/j.foodres.2007.10.010
7. 7. Zoumpopoulou G, Pot B, Tsakalidou E, Papadimitriou K. Dairy probiotics: Beyond the role of promoting gut ve immune health. Int. Dairy J. 2017;67:46-60. doi:https://doi.org/10.1016/j.idairyj.2016.09.010
8. 8. George-Kerry R, Patra JK, Gouda S, Park Y, Shin HS, Das G. Benefaction of probiotics for human health: A review. J Food Drug Anal. 2018;26(3): 927-939. doi:https://doi.org/10.1016/j.jfda.2018.01.002

9. 9. Taşdemir A. Probiyotikler, Prebiyotikler, Sinbiyotikler. Sağlık Akademisi Kastamonu. 2017;2(1):71-88.
10. 10. Guo Z, Liu XM, Zhang QX, Shen Z, Tian FW, Zhang H, et al. Influence of consumption of probiotics on the plasma lipid profile: A meta-analysis of randomised controlled trials. Nutr Metab Cardiovasc Dis. 2011;21:844–50
11. 11. Shimizu M, Hashiguchi M, Shiga T, Tamura HO, Mochizuki M. Meta-analysis: Effects of probiotic supplementation on lipid profiles in normal to mildly hypercholesterolemic individuals. PLoS ONE. 2015;10:e0139795.
12. 12. Cho YA, Kim J. Effect of probiotics on blood lipid concentrations: A meta-analysis of randomized controlled trials. Medicine. 2015;94:e1714.
13. 13. Wu Y, Zhang Q, Ren Y, Ruan Z. Effect of probiotic Lactobacillus on lipid profile: a systematic review and meta-analysis of randomized, controlled trials. PLoS ONE. 2017;12:e0178868
14. 14. Zhang Q, Wu Y, Fei X. Effect of probiotics on body weight and body-mass index: A systematic review and meta-analysis of randomized, controlled trials. Int J Food Sci Nutr. 2015;67:571–80
15. 15. Nikbakht E, Khalesi S, Singh I, Williams LT, West NP, Colson N. Effect of probiotics and synbiotics on blood glucose: A systematic review and meta-analysis of controlled trials. Eur J Nutr. 2016;57:95–106
16. 16. Kulkarni RP. Probiotics leap from gut to blood. Sci. Transl Med. 2019;11(521): eaaz9763. doi: https://doi.org/10.1126/scitranslmed.aaz9763
17. 17. Sullivan Å, Erik-Nord C. (2006). Probiotic lactobacilli and bacteraemia in Stockholm. Scand J Infect Dis. 2006;38(5):327-331. doi:https://doi.org/10.1080/00365540500449826
18. 18. Fleming PF, Berrington JE, Jacobs SE. Addressing safety concerns of probiotic use in preterm babies. Early Hum Dev. 2019;135:72-74. doi:https://doi.org/10.1016/j.earlhumdev.2019.05.016
19. 19. Haghighat L, Crum-Cianflone NF. The potential risks of probiotics among HIV-infected persons: Bacteraemia due to Lactobacillus acidophilus and review of the literature. Int J Std Aids. 2016;27(13):1223-1230. doi:https://doi.org/10.1177/0956462415590725
20. 20. Yelin I, Flett KB, Merakou C, et al. Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients. Nat Med. 2019;25(11):1728-1732. doi: https://doi.org/10.1038/s41591-019-0626-9
21. 21. Besselink MGH, van Santvoort HC, Buskens E, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a rveomised, double-blind, placebo-controlled trial. Lancet. 2008;371(9613):651-659. doi:https://doi.org/10.1016/S0140-6736(08)60207-X
22. 22. Vogel G. Deaths prompt: A review of experimental probiotic therapy. Science, 2008;319(5863):557-557. doi:https://doi.org/10.1126/science.319.5863.557a
23. 23. Honeycutt TC, El Khashab M, Wardrop RM, et al. Probiotic administration ve the incidence of nosocomial infection in pediatric intensive care: A randomized placebo-controlled trial. Pediatr Crit Care Med. 2007;8(5):452-458.
24. 24. Zmora N, Suez J, Elinav E. You are what you eat: diet, health and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2019;16:35–56. doi:https://doi.org/10.1038/s41575-018-0061-2
25. 25. Akıncı E, Orhan FÖ. Sirkadiyen ritim uyku bozuklukları. Psikiyatride Güncel Yaklaşımlar. 2016;8(2):178-189. doi: https://doi.org/10.18863/pgy.81775
26. 26. Paschos GK. Circadian clocks, feeding time, and metabolic homeostasis. Front Pharmacol. 2015;6(112). https://doi.org/10.3389/fphar.2015.00112
27. 27. Li Y, Hao Y, Fan F, Zhang B. The Role of Microbiome in Insomnia, Circadian Disturbance and Depression. Front Psychiatry. 2018;9(669). doi:https://doi.org/10.3389/fpsyt.2018.00669
28. 28. Voigt RM, Forsyth CB, Green SJ, Engen PA, Keshavarzian A. Circadian rhythm and the gut microbiome. Int Rev Neurobiol. 2016;131:193-205. doi: https://doi.org/10.1016/bs.irn.2016.07.002
29. 29. Schmidt TSB, Raes J, Bork P. The human gut microbiome: From association to modulation. Cell, 2018;172(6):1198-1215. doi:https://doi.org/10.1016/j.cell.2018.02.044
30. 30. Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA. Probiotics and prebiotics in intestinal health and disease: From biology to the clinic. Nat Rev Gastroenterol Hepatol. 2019;16(10):605-616. doi:https://doi.org/10.1038/s41575-019-0173-3
31. 31. TÜBA. Mikrobiyota ve insan sağlığı sempozyumu raporu. Ankara: Türkiye Bilimler Akademisi; 2017.
32. 32. Kajveer K, Krogius-Kurikka L, Rinttila T, Karjalainen H, Palva A, Korpela R. Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. Aliment Pharmacol Ther. 2007;26(3):463-473. doi:https://doi.org/10.1111/j.1365-2036.2007.03391.x
33. 33. Serban DE. Gastrointestinal cancers: Influence of gut microbiota, probiotics ve prebiotics. Cancer Lett. 2014;345(2):258-270. doi:https://doi.org/10.1016/j.canlet.2013.08.013
34. 34. Hsu YJ, Huang WC, Lin JS, et al. Kefir supplementation modifies gut microbiota composition, reduces physical fatigue, and improves exercise performance in mice. Nutrients. 2018;10(7):862. doi:https://doi.org/10.3390/nu10070862
35. 35. Riboulet-Bisson E, Sturme MH, Jeffery IB, et al. Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse ve pig intestinal microbiota. PloS One. 2012;7(2):e31113. doi:https://doi.org/10.1371/journal.pone.0031113
36. 36. Rawski M, Kierończyk B, Długosz J, Świątkiewicz S, Józefiak D. Dietary probiotics affect gastrointestinal microbiota, histological structure and shell mineralization in turtles. PloS One. 2016;11(2):e0147859. doi:https://doi.org/10.1371/journal.pone.0147859
37. 37. Kılınç GE. (2018). Obez ratlarda probiyotik ile d vitamini takviyesinin bağırsak mikrobiyotası ve d vitamini reseptör kompozisyonu üzerine etkilerinin deneysel olarak araştırılması. [yüksek lisans tezi]. Samsun: Ondokuz Mayıs Üniversitesi; 2018.
38. 38. Demir S, Yücel A. The relation of the grade of hepatic steatosis with the risk factors ve its association with cholelithiasis. Göztepe Tıp Dergisi. 2003;18(3): 132-134.
39. 39. Jang HR, Park HJ, Kang D, et al. Protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption. Exp Mol Med. 2019;51:1–14 doi:https://doi.org/10.1038/s12276-019-0293-4
40. 40. Wang, W, Xu, A. L, Li, et al. (2020). Combination of probiotics and salvia miltiorrhiza polysaccharide alleviates hepatic steatosis via gut microbiota modulation and insulin resistance improvement in high fat-induced NAFLD mice. Diabetes Metab. 2020;44(2):336–348. doi:https://doi.org/10.4093/dmj.2019.0042
41. 41. Yan Y, Liu C, Zhao S, et al. Probiotic Bifidobacterium lactis V9 attenuates hepatic steatosis and inflammation in rats with non-alcoholic fatty liver disease. AMB Expr. 2020;10:101. https://doi.org/10.1186/s13568-020-01038-y
42. 42. Chen YT, Lin YC, Lin JS, Yang NS, Chen MJ. Sugary kefir strain Lactobacillus mali APS1 ameliorated hepatic steatosis by regulation of SIRT-1/Nrf-2 and gut microbiota in rats. Mol Nutr Food Res. 2018;62(8):1700903. doi:https://doi.org/10.1002/mnfr.201700903
43. 43. Karaman A, Çakmak Ö. Nekrotizan enterokolit. Turkiye Klinikleri J Pediatr Surg-Special Topics. 2008;1(2):69-77.
44. 44. Esaiassen E, Hjerde E, Cavanagh JP, et al. Effects of probiotic supplementation on the gut microbiota and antibiotic resistome development in preterm infants. Front Pediatr. 2018;6(347). doi:https://doi.org/10.3389/fped.2018.00347
45. 45. Kural B. Çocuklarda kanıta dayalı probiyotik kullanımı. Osmangazi Tıp Dergisi Sosyal Pediatri Özel Sayısı 2020:41-44. https://doi.org/10.20515/otd.681546
46. 46. Oak SJ, Jha R. (2018). The effects of probiotics in lactose intolerance: A systematic review. Crit Rev Food Sci Nutr. 2018;59(11):1675-1683, doi:https://doi.org/10.1080/10408398.2018.1425977
47. 47. McFarlve, LV, Goh S. Are probiotics and prebiotics effective in the prevention of travellers’ diarrhea: A systematic review and meta-analysis. Travel Med Infect Dis.2019;27:11-19. doi:https://doi.org/10.1016/j.tmaid.2018.09.007
48. 48. Akdeniz V, Akalın AS, Özer E. Helicobacter pylori enfeksiyonunda probiyotiklerin rolü. Gıda. 2018;43(6):943-956. doi:https://doi.org/10.15237/gida.GD18062
49. 49. Mota JF, Walter J, Prado CM. (2018). Insights into the relationship between gut microbiota and colorectal cancer. Curr Colorectal Cancer Rep. 2018;14: 251–265. doi:https://doi.org/10.1007/s11888-018-0419-4
50. 50. Uccello M, Malaguarnera G, Basile F, et al. Potential role of probiotics on colorectal cancer prevention. BMC Surgery. 2012;12(1):S35. doi:https://doi.org/10.1186/1471-2482-12-s1-s35
51. 51. Pärtty A, Rautava S, Kalliomäki M. Probiotics on pediatric functional gastrointestinal disorders. Nutrients, 2018;10(12):1836.
52. 52. Ede E, Yoldaş-İlktaç H. İrritable bağırsak sendromunda güncel diyet yaklaşımları. İstanbul Sabahattin Zaim Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2019;1(1):1-6.
53. 53. Karacaer C, Varım C, Toka B, Yaylacı S, Genç AB. Bağırsak mikrobiyatası, probiyotikler ve İrritable Bağırsak Sendromu (İBS). Journal of Human Rhythm. 2017;3(3):120-125.
54. 54. Guzel-Seydim Z, Greene AK, Seydim AC, Kök-Taş T. Effects of ferment dairy products against cancer, pathogens and other health issues. Zhou JR, Martirosyan DM, eds. Texas: Food Science Publisher; 2017.35-61
55. 55. Hikmetoglu M, Sogut E, Sogut O, Gokirmakli C, Guzel-Seydim ZB. (2020). Changes in carbohydrate profile in kefir fermentation. Bioact Carbohydr Diet Fibre. 2020;23:100220. doi:https://doi.org/10.1016/j.bcdf.2020.100220
56. 56. Kim DH, Kim H, Jeong D, et al. (2017). Kefir alleviates obesity and hepatic steatosis in high-fat diet-fed mice by modulation of gut microbiota and mycobiota: targeted and untargeted community analysis with correlation of biomarkers. J Nutr Biochem. 2017;44:35-43. doi:https://doi.org/10.1016/j.jnutbio.2017.02.014
57. 57. Erdogan FS, Ozarslan S, Guzel-Seydim ZB, Taş TK. (2019). The effect of kefir produced from natural kefir grains on the intestinal microbial populations and antioxidant capacities of Balb/c mice. Food Res Int. 2019;115:408-413. doi:https://doi.org/10.1016/j.foodres.2018.10.080
58. 58. Gao J, Ding G, Li Q, Gong L, Huang J, Sang Y. Tibet kefir milk decreases fat deposition by regulating the gut microbiota and gene expression of Lpl and Angptl4 in high fat diet-fed rats. Food Res Int. 2019;121:278-287. doi:https://doi.org/10.1016/j.foodres.2019.03.029
59. 59. Kim DH, Jeong D, Kang IB, Lim HW, Cho Y, Seo KH. Modulation of the intestinal microbiota of dogs by kefir as a functional dairy product. J Dairy Sci. 2019;102(5):3903-3911. doi:https://doi.org/10.3168/jds.2018-15639
60. 60. Yılmaz İ, Dolar ME, Özpınar H. Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial. Turk J Gastroenterol. 2019;30(3):242-53. doi:https://doi.org/10.5152/tjg.2018.18227
61. 61. Kim DH, Chon JW, Kim H, Seo KH. Modulation of intestinal microbiota in mice by kefir administration. Food Sci Biotechnol. 2015;24(4):1397-1403.
62. 62. Yücel-Şengün İ, Kırmızıgül A, Kılıç G, Öztürk B. Gıda işletmelerinde COVID-19 salgınına yönelik alınması gereken önlemler ve etkin dezenfeksiyon uygulamaları. GIDA. 2020;45(4):646-664 doi:https://doi.org/10.15237/gida.GD20075
63. 63. Kalantar-Zadeh K, Moore LW. Impact of nutrition and diet on COVID-19 infection and implications for kidney health and kidney disease management. J Ren Nutr. 2020;30(3):179-181. doi:https://doi.org/10.1053/j.jrn.2020.03.006
64. 64. Bayram M, Springer S, Garvey CK, Özdemir V. COVID-19 digital health innovation policy: A portal to alternative futures in the making. OMICS. 2020;24(8):460-469. http://doi.org/10.1089/omi.2020.0089
65. 65. Butler MJ, Barrientos RM. The impact of nutrition on COVID-19 susceptibility and long-term consequences. Brain Behav Immun. 2020;87:53-54. doi:https://doi.org/10.1016/j.bbi.2020.04.040
66. 66. Guzel-Seydim ZB, Dibekci M, Cagdas E, Seydim AC. Effect of kefir on Fusobacterium nucleatum in potentially preventing intestinal cancer. Funct Food Health Dis. 2016;6(7):469-477. doi: https://doi.org/10.31989/ffhd.v6i7.272
67. 67. Uymaz B. Probiyotikler ve kullanım alanları. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. 2010;16(1):95-104.
68. 68. Yılmaz B, Akbulut G. İrritabl bağırsak sendromuna güncel bakış. Beslenme ve Diyet Dergisi. 2018;46(3):276-284. doi:https://doi.org/10.33076/2018.BDD.309