Erratum

Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings

Volume: 10 Number: 1 September 16, 2026
EN TR

Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings

Abstract

Abstract: This study aimed to investigate the effects of experimentally induced diabetes on renal tissue by evaluating biochemical parameters, cytokine levels (IL-2 and IL-10), and histopathological alterations in rats. Twelve adult male Wistar albino rats were used and randomly divided into control and diabetic groups. Experimental diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg/kg). At the end of the experimental period, kidney tissues and serum samples were collected under anesthesia. Serum glucose levels were measured to confirm diabetes induction. Renal IL-2 and IL-10 levels were determined using ELISA. Histopathological evaluation of kidney tissues was performed using Hematoxylin–Eosin and Masson’s Trichrome staining and tissue damage was assessed semi-quantitatively. Serum glucose levels were significantly elevated in the diabetic group compared to the control group (p < 0.01). Renal cytokine analysis demonstrated a significant decrease in both IL-2 and IL-10 levels in diabetic rats (p < 0.01). Histopathological examination revealed marked structural alterations in the diabetic group, including degeneration of renal corpuscles, tubular epithelial degeneration, vascular congestion, and perivascular fibrotic scar formation. In contrast, the control group exhibited normal renal histological architecture. Experimental diabetes induced by streptozotocin leads to significant biochemical, immunological, and histopathological changes in renal tissue. The observed decrease in both pro- and anti-inflammatory cytokines suggests impaired immune regulation, which may contribute to the development of diabetic kidney injury. These findings highlight the role of cytokine imbalance in the pathogenesis of diabetic nephropathy.

Keywords

Details

Primary Language

English

Subjects

Systems Biology

Journal Section

Erratum

Publication Date

September 16, 2026

Submission Date

September 9, 2026

Acceptance Date

September 14, 2026

Published in Issue

Year 2026 Volume: 10 Number: 1

APA
Koçak, S., Kalkan, K. T., Çalışkan, H., & Dağlıoğlu, K. (2026). Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings. Commagene Journal of Biology, 10(1). https://izlik.org/JA32KH65KS
AMA
1.Koçak S, Kalkan KT, Çalışkan H, Dağlıoğlu K. Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings. Comm. J. Biol. 2026;10(1). https://izlik.org/JA32KH65KS
Chicago
Koçak, Seda, Kübra Tuğçe Kalkan, Hasan Çalışkan, and Kenan Dağlıoğlu. 2026. “Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings”. Commagene Journal of Biology 10 (1). https://izlik.org/JA32KH65KS.
EndNote
Koçak S, Kalkan KT, Çalışkan H, Dağlıoğlu K (September 1, 2026) Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings. Commagene Journal of Biology 10 1
IEEE
[1]S. Koçak, K. T. Kalkan, H. Çalışkan, and K. Dağlıoğlu, “Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings”, Comm. J. Biol., vol. 10, no. 1, Sept. 2026, [Online]. Available: https://izlik.org/JA32KH65KS
ISNAD
Koçak, Seda - Kalkan, Kübra Tuğçe - Çalışkan, Hasan - Dağlıoğlu, Kenan. “Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings”. Commagene Journal of Biology 10/1 (September 1, 2026). https://izlik.org/JA32KH65KS.
JAMA
1.Koçak S, Kalkan KT, Çalışkan H, Dağlıoğlu K. Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings. Comm. J. Biol. 2026;10. Available at https://izlik.org/JA32KH65KS.
MLA
Koçak, Seda, et al. “Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings”. Commagene Journal of Biology, vol. 10, no. 1, Sept. 2026, https://izlik.org/JA32KH65KS.
Vancouver
1.Seda Koçak, Kübra Tuğçe Kalkan, Hasan Çalışkan, Kenan Dağlıoğlu. Effects of Diabetes on the Kidney: Analysis of IL-2 and IL-10 Levels and Histopathological Findings. Comm. J. Biol. [Internet]. 2026 Sep. 1;10(1). Available from: https://izlik.org/JA32KH65KS