The efficacy of adalimumab in the treatment of hidradenitis suppurativa

Ali Balevi; Pelin Ustuner; Mustafa Özdemir

doi:10.5798/dicletip.407240

The efficacy of adalimumab in the treatment of hidradenitis suppurativa

Abstract

Objectives: Hidradenitis suppurativa is seen as a result of the occlusion, constriction and bacterial infection of the apocrine glands in bilateral axillas, submammarian areas, neck, inguinal regions, flexural surfaces of the thighs and anogenital areas. Among the biological agents adalimumab is a recombinant human IgG1 monoclonal antibody; TNF-α antagonist approved to be used in the treatment of hidradenitissuppurativa.

Methods: In this study, 12 patients resistant to conventional treatments with moderate severity, Hurley stage 2 or 3 were started subcutaneous adalimumab treatment. The disease activities upon the hidradenitis suppurativa, clinical severity index and life quality index of the patients were examined both before and 1 year after the treatment.

Results: Twelve patients were recruited. In the examination of the hidradenitis suppurativa clinical severity scores, significant clinical responses were noted in 9 (75%) patients. While the mean value of the life quality index was 14.4±6.9 before the treatment, it was determined to be significantly decreased to 4.3±3.8 after the treatment.

Conclusion: We concluded that adalimumab; the unique biological agent approved to be used in the treatment of treatment-resistant, moderate-severe hidradenitis suppurativa is efficient and safe in similar ratios with the previous clinical studies in the literature.

Keywords

Adalimumab,eccrine glands

References

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Ali Balevi This is me
0000-0001-5057-0405
Türkiye

Pelin Ustuner ^*
0000-0002-7885-0537
Türkiye

Mustafa Özdemir This is me
0000-0002-7022-913X
Türkiye

Publication Date

March 17, 2018

Submission Date

March 17, 2018

Acceptance Date

December 28, 2017

Published in Issue

Year 2018 Volume: 45 Number: 1

DOI

https://doi.org/10.5798/dicletip.407240

IZ

https://izlik.org/JA25AH82GD

Cite

RIS / Bibtex

APA

Balevi, A., Ustuner, P., & Özdemir, M. (2018). The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Medical Journal, 45(1), 19-27. https://doi.org/10.5798/dicletip.407240

AMA

1.Balevi A, Ustuner P, Özdemir M. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Medical Journal. 2018;45(1):19-27. doi:10.5798/dicletip.407240

Chicago

Balevi, Ali, Pelin Ustuner, and Mustafa Özdemir. 2018. “The Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa”. Dicle Medical Journal 45 (1): 19-27. https://doi.org/10.5798/dicletip.407240.

EndNote

Balevi A, Ustuner P, Özdemir M (March 1, 2018) The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Medical Journal 45 1 19–27.

IEEE

[1]A. Balevi, P. Ustuner, and M. Özdemir, “The efficacy of adalimumab in the treatment of hidradenitis suppurativa”, Dicle Medical Journal, vol. 45, no. 1, pp. 19–27, Mar. 2018, doi: 10.5798/dicletip.407240.

ISNAD

Balevi, Ali - Ustuner, Pelin - Özdemir, Mustafa. “The Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa”. Dicle Medical Journal 45/1 (March 1, 2018): 19-27. https://doi.org/10.5798/dicletip.407240.

JAMA

1.Balevi A, Ustuner P, Özdemir M. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Medical Journal. 2018;45:19–27.

MLA

Balevi, Ali, et al. “The Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa”. Dicle Medical Journal, vol. 45, no. 1, Mar. 2018, pp. 19-27, doi:10.5798/dicletip.407240.

Vancouver

1.Ali Balevi, Pelin Ustuner, Mustafa Özdemir. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Medical Journal. 2018 Mar. 1;45(1):19-27. doi:10.5798/dicletip.407240