The efficacy of adalimumab in the treatment of hidradenitis suppurativa

Ali Balevi; Pelin Ustuner; Mustafa Özdemir

doi:10.5798/dicletip.407240

The efficacy of adalimumab in the treatment of hidradenitis suppurativa

Öz

Objectives: Hidradenitis suppurativa is seen as a result of the occlusion, constriction and bacterial infection of the apocrine glands in bilateral axillas, submammarian areas, neck, inguinal regions, flexural surfaces of the thighs and anogenital areas. Among the biological agents adalimumab is a recombinant human IgG1 monoclonal antibody; TNF-α antagonist approved to be used in the treatment of hidradenitissuppurativa.

Methods: In this study, 12 patients resistant to conventional treatments with moderate severity, Hurley stage 2 or 3 were started subcutaneous adalimumab treatment. The disease activities upon the hidradenitis suppurativa, clinical severity index and life quality index of the patients were examined both before and 1 year after the treatment.

Results: Twelve patients were recruited. In the examination of the hidradenitis suppurativa clinical severity scores, significant clinical responses were noted in 9 (75%) patients. While the mean value of the life quality index was 14.4±6.9 before the treatment, it was determined to be significantly decreased to 4.3±3.8 after the treatment.

Conclusion: We concluded that adalimumab; the unique biological agent approved to be used in the treatment of treatment-resistant, moderate-severe hidradenitis suppurativa is efficient and safe in similar ratios with the previous clinical studies in the literature.

Anahtar Kelimeler

Adalimumab,eccrine glands

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Ali Balevi Bu kişi benim
0000-0001-5057-0405
Türkiye

Pelin Ustuner ^*
0000-0002-7885-0537
Türkiye

Mustafa Özdemir Bu kişi benim
0000-0002-7022-913X
Türkiye

Yayımlanma Tarihi

17 Mart 2018

Gönderilme Tarihi

17 Mart 2018

Kabul Tarihi

28 Aralık 2017

Yayımlandığı Sayı

Yıl 2018 Cilt: 45 Sayı: 1

DOI

https://doi.org/10.5798/dicletip.407240

IZ

https://izlik.org/JA25AH82GD

Kaynak Göster

RIS / Bibtex

APA

Balevi, A., Ustuner, P., & Özdemir, M. (2018). The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Medical Journal, 45(1), 19-27. https://doi.org/10.5798/dicletip.407240

AMA

1.Balevi A, Ustuner P, Özdemir M. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. diclemedj. 2018;45(1):19-27. doi:10.5798/dicletip.407240

Chicago

Balevi, Ali, Pelin Ustuner, ve Mustafa Özdemir. 2018. “The efficacy of adalimumab in the treatment of hidradenitis suppurativa”. Dicle Medical Journal 45 (1): 19-27. https://doi.org/10.5798/dicletip.407240.

EndNote

Balevi A, Ustuner P, Özdemir M (01 Mart 2018) The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Medical Journal 45 1 19–27.

IEEE

[1]A. Balevi, P. Ustuner, ve M. Özdemir, “The efficacy of adalimumab in the treatment of hidradenitis suppurativa”, diclemedj, c. 45, sy 1, ss. 19–27, Mar. 2018, doi: 10.5798/dicletip.407240.

ISNAD

Balevi, Ali - Ustuner, Pelin - Özdemir, Mustafa. “The efficacy of adalimumab in the treatment of hidradenitis suppurativa”. Dicle Medical Journal 45/1 (01 Mart 2018): 19-27. https://doi.org/10.5798/dicletip.407240.

JAMA

1.Balevi A, Ustuner P, Özdemir M. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. diclemedj. 2018;45:19–27.

MLA

Balevi, Ali, vd. “The efficacy of adalimumab in the treatment of hidradenitis suppurativa”. Dicle Medical Journal, c. 45, sy 1, Mart 2018, ss. 19-27, doi:10.5798/dicletip.407240.

Vancouver

1.Ali Balevi, Pelin Ustuner, Mustafa Özdemir. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. diclemedj. 01 Mart 2018;45(1):19-27. doi:10.5798/dicletip.407240