Do neutrophil-lymphocyte ratio and platelet-lymphocyte ratio correlate with clinical and endoscopic activity indices in ulcerative colitis patients?

Year 2020, , 5 - 11, 30.04.2020

Serkan Yalaki , Mehmet Suat Yalçın , Hüseyin Pulat Aysu İlhan

https://doi.org/10.17940/endoskopi.646673

Abstract

Objective:
Classification
of ulcerative colitis (UC) according to disease activity and severity is
important in clinical practice because it determines the management of the
patient. In this study, we aimed to investigate the relationship between
neutrophil lymphocyte ratios (NLR) and platelet lymphocyte ratios (PLR) with
clinical activity index (CAI) in UC patients as well as endoscopic activity
indexes (EIA) that determine disease severity relative to mucosal disease.

Materials
and Methods: The study was planned as a retrospective
single-center study. Active disease and remission groups were formed from 99
newly diagnosed UC patients according to their CAIs and EAIs. The control group
consisted of 56 healthy subjects.

Results:
Serum
NLR and PLR levels of clinically active patients were significantly higher than
inactive UC and control groups (p <0.01). The cut-off values for NLR and PLR
were 2.10 (90% sensitivity, 45% specificity) and 152.13 (70% sensitivity, 33%
specificity), respectively. Serum NLR and PLR of endoscopically active patients
were significantly higher than inactive UC and control group (p <0.01). The
cut-off values for NLR and PLR were 2.09 (97% sensitivity, 39% specificity) and
151.72 (73% sensitivity, 31% specificity), respectively.

Conclusion:
Our
study showed that NLR and PLR levels were significantly increased in active UC
patients and correlated with clinical, endoscopic and laboratory indices. These
inflammatory markers can predict disease activity alone or in combination.

Keywords

Ulcerative colitis, Neutrophil lymphocyte ratio, Platelet lymphocyte ratio, Endoscopic activity index, Clinical activity index

Ülseratif kolit hastalarında nötrofil lenfosit oranı ve platelet lenfosit oranı, klinik ve endoskopik aktivite indeksleri ile ilişkili mi?

Abstract

Amaç:
Ülseratif
kolitin (ÜK) hastalık aktivitesine ve ciddiyetine göre sınıflandırılması klinik
uygulamada önemlidir, çünkü hastanın yönetimini belirler. Bu çalışmada,
nötrofil lenfosit oranları (NLR) ve platelet lenfosit oranlarının (PLR), ÜK
hastalarında klinik aktivite indeksinin (KAİ) yanı sıra mukozal hastalığa göre
hastalık şiddetini belirleyen endoskopik aktivite indeksleri (EAİ) ile olan
ilişkilerinin ortaya konulması amaçlanmıştır.

Materyal
ve Metot: Çalışma retrospektif tek merkezli çalışma olarak
planlandı. Yeni tanı almış 99 ÜK’li hastadan KAİ’lerine ve EAİ’lerine göre
aktif hastalık ve remisyon grupları oluşturuldu. Kontrol grubu 56 sağlıklı
bireyden oluşturuldu.

Bulgular:
Klinik
aktif
hastaların serum NLR’ı ve PLR’ı, inaktif ÜK ve kontrol grubuna göre anlamlı
derecede yüksekti (p<0,01). NLR ve PLR için kesme değerleri sırasıyla 2,10
(%90 sensitivite, %45 spesifite) ve 152,13 (%70 sensitivite, %33 spesifite)
olarak saptandı. Endoskopik aktif hastaların serum NLR’ı ve PLR’ı, inaktif ÜK
ve kontrol grubuna göre anlamlı derecede yüksekti (p<0,01). NLR ve PLR için
kesme değerleri sırasıyla 2,09 (%97 sensitivite, %39 spesifite) ve 151,72 (%73
sensitivite, %31 spesifite) olarak saptandı.

Sonuç: Çalışmamız
aktif ÜK hastalarında NLR ve PLR seviyelerinin anlamlı şekilde arttığını ve
bunun klinik, endoskopik ve laboratuvar endeksleri ile korele olduğunu
göstermiştir. Bu inflamatuar belirteçler tek başına ya da birlikte hastalık
aktivitesini tahmin edebilir.

Keywords

Ülseratif kolit, Nötrofil lenfosit oranı, Platelet lenfosit oranı, Endoskopik aktivite indeksi, Klinik aktivite indeksi

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