Removal of pharmaceutically active compounds from hospital wastewater by ozonation pretreatment

Mahammad Mansımlı; Havva Ateş

doi:10.35208/ert.1511061

Removal of pharmaceutically active compounds from hospital wastewater by ozonation pretreatment

Abstract

Hospital wastewater includes many pharmaceutically active compounds (PhACs). Since this resulted in both PhACs distribution to the environment and development of antibiotic resistance in microorganisms, on-site treatment of hospital wastewater has gained importance. In this study, the removal of 21 PhACs consisting of 12 parent compounds and 9 main metabolites from hospital wastewater by ozonation was investigated. In this context, commonly used analgesics (Paracetamol, Diclofenac, Ibuprofen, and Naproxen, 4'-Hydroxydiclofenac, 5-Hydroxydiclofenac, 1-Hydroxyibuprofen, 2-Hydroxyibuprofen, Carboxyibuprofen, (S)-O-Desmethyl naproxen) and antibiotics (Ciprofloxacin, Sulfamethoxazole, Trimethoprim, Erythromycin, Metronidazole, Clarithromycin, Azithromycin, Clindamycin, N-Acetyl-Sulfamethoxazole, Sulfamethoxazole-β-D-Glucuronide, Clindamycin sulfoxide) were selected. PhAC analyses were performed by HPLC/MS-MS. The ozonation dose was between 0.05-5.0 mg O3/mg COD. In real hospital wastewater, many of the selected PhACs were detected and total analgesic and antibiotic were determined as 22.9 and 40.6 µg/L, respectively. The results showed that detected PhACs were completely removed at 1.5 mg O3/mg COD. Sulfamethoxazole was degraded at the lowest dose of ozone (0.05mg O3/mg COD), while Ciprofloxacin and 2-Hydroxy ibuprofen were relatively resistant to non-stoichiometric doses of ozone. The removal efficiencies of Ciprofloxacin and 2-Hydroxy ibuprofen were determined as 77% and 37%, respectively, at 0.5 mg O3/mg COD. Additionally, COD removal was 48% at 1.5 mg O3/mg COD. As a result, pre-oxidation of hospital wastewater can be an effective method for on-site pretreatment of PhACs.

Keywords

Supporting Institution

Konya Technical University

Project Number

241001022

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Details

Primary Language

English

Subjects

Environmental Pollution and Prevention

Journal Section

Research Article

Authors

Mahammad Mansımlı
0009-0002-9700-1087
Azerbaijan

Havva Ateş ^*
0000-0001-7506-6811
Türkiye

Publication Date

September 30, 2025

Submission Date

July 5, 2024

Acceptance Date

November 8, 2024

Published in Issue

Year 2025 Volume: 8 Number: 3

DOI

https://doi.org/10.35208/ert.1511061

IZ

https://izlik.org/JA74MD29PZ

Cite

RIS / Bibtex

APA

Mansımlı, M., & Ateş, H. (2025). Removal of pharmaceutically active compounds from hospital wastewater by ozonation pretreatment. Environmental Research and Technology, 8(3), 571-580. https://doi.org/10.35208/ert.1511061

AMA

1.Mansımlı M, Ateş H. Removal of pharmaceutically active compounds from hospital wastewater by ozonation pretreatment. ERT. 2025;8(3):571-580. doi:10.35208/ert.1511061

Chicago

Mansımlı, Mahammad, and Havva Ateş. 2025. “Removal of Pharmaceutically Active Compounds from Hospital Wastewater by Ozonation Pretreatment”. Environmental Research and Technology 8 (3): 571-80. https://doi.org/10.35208/ert.1511061.

EndNote

Mansımlı M, Ateş H (September 1, 2025) Removal of pharmaceutically active compounds from hospital wastewater by ozonation pretreatment. Environmental Research and Technology 8 3 571–580.

IEEE

[1]M. Mansımlı and H. Ateş, “Removal of pharmaceutically active compounds from hospital wastewater by ozonation pretreatment”, ERT, vol. 8, no. 3, pp. 571–580, Sept. 2025, doi: 10.35208/ert.1511061.

ISNAD

Mansımlı, Mahammad - Ateş, Havva. “Removal of Pharmaceutically Active Compounds from Hospital Wastewater by Ozonation Pretreatment”. Environmental Research and Technology 8/3 (September 1, 2025): 571-580. https://doi.org/10.35208/ert.1511061.

JAMA

1.Mansımlı M, Ateş H. Removal of pharmaceutically active compounds from hospital wastewater by ozonation pretreatment. ERT. 2025;8:571–580.

MLA

Mansımlı, Mahammad, and Havva Ateş. “Removal of Pharmaceutically Active Compounds from Hospital Wastewater by Ozonation Pretreatment”. Environmental Research and Technology, vol. 8, no. 3, Sept. 2025, pp. 571-80, doi:10.35208/ert.1511061.

Vancouver

1.Mahammad Mansımlı, Havva Ateş. Removal of pharmaceutically active compounds from hospital wastewater by ozonation pretreatment. ERT. 2025 Sep. 1;8(3):571-80. doi:10.35208/ert.1511061

Cited By

Advanced Treatment and Disinfection of Hospital Wastewater: Progress, Monitoring Gaps, and Trends

Water

https://doi.org/10.3390/w18050605