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A New Low Calorie Sweetener D-Tagatose from Lactose in Cheese Whey as a Nutraceutical Value-Added Product

Year 2018, Volume: 1 Issue: 1, 11 - 28, 04.03.2018

Abstract

In this manuscript content, a new low calorie sweetener D-tagatose from lactose in cheese whey has been described. These research results are showing progress in improving enzymes bioconversion rate, thermos ability in increasing the half-life of the immobilized enzyme, shorting enzyme reaction time and improving both bioconversion efficiency for the hydrolysis of lactose to lactose hydrolysate (D-glucose and D-galactose) and for isomerization of D-galactose to higher yield of D-tagatose.

References

  • Beadle JR, Saunder JP, Wajada TJ. 1992. Process for manufacturing tagatose. US Patent 5,078,796. Ibrahim OO, Spradlin JE. 2000. Process for manufacturing D-tagatose. US Patent 6,057,135.
  • Bertelsen, H., Jensen, B.B. & Buemann, B.1999. D-Tagatose –a novel low-calorie bulk sweetener with prebiotic properties. World Rev. Nutr. Diet, 85: 98-109. Buemann B, Toubro S, Astrup A. 1998. D-Tagatose, a stereoisomer of D-fructose, increases hydrogen production in humans without affecting 24-hour energy expenditure or respiratory exchange ratio. J Nutr 128:1481–1486.
  • Levin, G.V., Zehner, L.R., Saunders, J.P. & Beadle, J.R.1995. Sugar substitutes: their energy values, bulk characteristics, and potential health benefits. Am. J. Clin. Nutr., 62(5 Supple): 1161S-1168S.
  • Armstrong, M. Laura, Katherine J. Luecke&Leonard N. Bell. 2009. Consumer evaluation of bakery product flavour as affected by incorporating the prebiotic tagatose. International Journal of Food Science and Technology, 44, 815–819.
  • Lina B.A.R. and Kuper C.F. 2002. Chronic toxicity and carcinogenicity study with D-tagatose. TNO Nutrition and Food Research, The Netherlands, Report Number V 4533. Adachi S.1958. Formation of lactulose and tagatose from lactose in strongly heated milk. Nature 181:840–841.
  • Levin, G.V., Zehner, L.R., Saunders, J.P. & Beadle, J.R. 1995. Sugar substitutes: their energy values, bulk characteristics, and potential health benefits. Am. J. Clin. Nutr., 62 (5 Supple): 1161S-1168S.
  • Hirst E.L., Hough L., and Jones J.K. N. 1949.The structure of Sterculla Setigera gum. Part 1: The investigation by the method of paper partition chromatography of the products of hydrolysis of the gum. J. chem. Soc. 3145-3151.
  • Elin S., Olarsdottir Kristine Igolfsdottir. 2001. Polysaccharide from Lichens: structural, characteristics, and biological activities. Planta Med. 67: 199-208. Marshall R., Kooi E.1957. "Enzymatic conversion of D-glucose to D-fructose". Science. 125: 648–9.
  • Nakamatu T, Yamanaka K.1969. "Crystallization and properties of L-arabinose isomerase from Lactobacillus gayonii". Biochim. Biophys. Acta.; 178 (1): 156–65. Patrick, J. & Lee, N. 1975. L-arabinose isomerase. Methods in Enzymology 41, 453-458
  • Sang-Jae Lee1,Dong-Woo Lee ,Eun-Ah Choe, Young-Ho Hong,Seong-Bo Kim, Byoung-Chan Kim and Yu-Ryang Pyun. 2005. Characterization of a Thermoacidophilic L-Arabinose Isomerase from Alicyclobacillus acidocaldarius: Appli. Environ. Microbiol. 71 (12), 7888– 7896. Manzo R.M., Simonetta A. C., Rubiolo A. C., Mammarella E. J. 2013. Screening and selection of wild strains for L-arabinose isomerase production. Braz. J. Chem. Eng . Vol. 30, No. 04, 711 – 720.
  • Yan Men, Yueming Zhu, Lili Zhang, , Zhenkui Kang, Ken Izumori,, Yuanxia Sun,, and Yanhe Ma. 2014. Enzymatic conversion of D-galactose to D-tagatose: Cloning, overexpression and characterization of L-arabinose isomerase from Pediococcus pentosaceus PC-5 . Microbial Research. 169, Issues 2–3, 171-178. Kim P, Yoon SH, Roh HJ, Choi JH. 2001. High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase. Biotechnol. Prog .17: 208-210 (2001)
  • Charles Ling K.2008. Whey to ethanol: A biofuel role for cooperative? . Rural Business and Cooperative, program, Research report 214 February 2008. Douglas C. Elliott, Christopher F. wend, and Mikhail S, Alnajjar.2001; Lactose processing technology-Creating new utilization opportunities. 38th Annual Marshall Cheese seminar”tools for the trade.
  • Demaimay M., LeHenaff Y, and Printemps P. 1978. Hydrolysis of Lactose on catalytic Resin. Process Biochemistry 3-5.
  • Donner T.W, Wilber J.F., and Ostrowski D. 1999. D-tagatose a novel hexose: Acute effects on carbohydrate tolerance in subjects with and without type 2 diabetes. Diabetes, Obesity and metabolism 1:285-29.
  • Levin G. V. 2002. Tagatose, the new GRAS sweetener and health product. J. Med Food, 5,23-36.
  • Livesey G., Brown J.C. 1996. D-tagatose is a bulk sweetener with zero energy determined in rats. J. Nutr.126, 1601-1609.
  • Food and Drug Administration (FDA). 2004. D-tagatose.
  • Johansen H.N., and Jensen B.B. 1997. Recovery of energy as SCFA after microbial fermentation of D-tagatose. Int. J. Obes. (suppl.2) 21:S50 (abs).
  • Buemann B, Toubro S, and Astrup A. 1998. Tagatose a stereoisomer of D-tagatose a stereoisomer of D-fructose, increases hydrogen production in human without affecting 24-hour energy expenditure of respiratory exchange ratio. J. Nutr. 128:1481-1486.
  • Lu Y. G. V Levin, and T.W. Donner. 2008. Tagatose, a new antidiabetic and obesitycontrol Drug, diabetes, Obesity, and Metabolism 10: 109-134.
  • Buemann B, Gesmar H., Astrup A, and Quistorff B. 2000. Effects of oral D-tagatose, a stereoisomer of D-fructose, on liver metabolism in man as examined by 3 PMRS. Metabolism 49:1335-1339.
  • Espinosa I., and Fogelfeld L. 2010. Tagatose; from sweetener to a new diabetic medication? Expert Opin Investig Drugs 19: 285-294. Bar A. 2000. Dossier prepared on behalf of Arla Food ingredients amba, Viby, Denmark for safety assessment of D-tagatose by a panel of independent experts. Cited in GRN 000078.
  • Food and Drug Administration (FDA). 2003. Food labeling. Health claims. D-tagatose and dental caries. Final rule. Fed Reg. .68:39831-39833. Bar A. 2004. Tagatose: Food Scientific Regulatory Service. Bioresco.
  • Buemann B., Toubro S., Holst J. J., Rehfeld J., and Astrup A. 1999. D-tagatose stereoisomer of D-fructose , increases blood uric acid concentration . Metabolism 49: 969-976.
  • Marta W., and Jozef K. 2012. A method for the production of D-tagatose a recombinant Pichia pastoris strain secreting B-DD-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp.22cMicrob.Cell Fact. 11-13.
  • Yan Men, Yueming Zhu, Lili Zhang, , Zhenkui Kang, Ken Izumori,, Yuanxia Sun,, and Yanhe Ma. 2014. Enzymatic conversion of D-galactose to D-tagatose: Cloning, overexpression and characterization of L-arabinose isomerase from Pediococcus pentosaceus PC-5 . Microbial Research. 169, 2–3, 171-178.
  • Kim P, Yoon SH, Roh HJ, Choi JH. 2001. High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase. Biotechnol. 17, 208-210.
Year 2018, Volume: 1 Issue: 1, 11 - 28, 04.03.2018

Abstract

References

  • Beadle JR, Saunder JP, Wajada TJ. 1992. Process for manufacturing tagatose. US Patent 5,078,796. Ibrahim OO, Spradlin JE. 2000. Process for manufacturing D-tagatose. US Patent 6,057,135.
  • Bertelsen, H., Jensen, B.B. & Buemann, B.1999. D-Tagatose –a novel low-calorie bulk sweetener with prebiotic properties. World Rev. Nutr. Diet, 85: 98-109. Buemann B, Toubro S, Astrup A. 1998. D-Tagatose, a stereoisomer of D-fructose, increases hydrogen production in humans without affecting 24-hour energy expenditure or respiratory exchange ratio. J Nutr 128:1481–1486.
  • Levin, G.V., Zehner, L.R., Saunders, J.P. & Beadle, J.R.1995. Sugar substitutes: their energy values, bulk characteristics, and potential health benefits. Am. J. Clin. Nutr., 62(5 Supple): 1161S-1168S.
  • Armstrong, M. Laura, Katherine J. Luecke&Leonard N. Bell. 2009. Consumer evaluation of bakery product flavour as affected by incorporating the prebiotic tagatose. International Journal of Food Science and Technology, 44, 815–819.
  • Lina B.A.R. and Kuper C.F. 2002. Chronic toxicity and carcinogenicity study with D-tagatose. TNO Nutrition and Food Research, The Netherlands, Report Number V 4533. Adachi S.1958. Formation of lactulose and tagatose from lactose in strongly heated milk. Nature 181:840–841.
  • Levin, G.V., Zehner, L.R., Saunders, J.P. & Beadle, J.R. 1995. Sugar substitutes: their energy values, bulk characteristics, and potential health benefits. Am. J. Clin. Nutr., 62 (5 Supple): 1161S-1168S.
  • Hirst E.L., Hough L., and Jones J.K. N. 1949.The structure of Sterculla Setigera gum. Part 1: The investigation by the method of paper partition chromatography of the products of hydrolysis of the gum. J. chem. Soc. 3145-3151.
  • Elin S., Olarsdottir Kristine Igolfsdottir. 2001. Polysaccharide from Lichens: structural, characteristics, and biological activities. Planta Med. 67: 199-208. Marshall R., Kooi E.1957. "Enzymatic conversion of D-glucose to D-fructose". Science. 125: 648–9.
  • Nakamatu T, Yamanaka K.1969. "Crystallization and properties of L-arabinose isomerase from Lactobacillus gayonii". Biochim. Biophys. Acta.; 178 (1): 156–65. Patrick, J. & Lee, N. 1975. L-arabinose isomerase. Methods in Enzymology 41, 453-458
  • Sang-Jae Lee1,Dong-Woo Lee ,Eun-Ah Choe, Young-Ho Hong,Seong-Bo Kim, Byoung-Chan Kim and Yu-Ryang Pyun. 2005. Characterization of a Thermoacidophilic L-Arabinose Isomerase from Alicyclobacillus acidocaldarius: Appli. Environ. Microbiol. 71 (12), 7888– 7896. Manzo R.M., Simonetta A. C., Rubiolo A. C., Mammarella E. J. 2013. Screening and selection of wild strains for L-arabinose isomerase production. Braz. J. Chem. Eng . Vol. 30, No. 04, 711 – 720.
  • Yan Men, Yueming Zhu, Lili Zhang, , Zhenkui Kang, Ken Izumori,, Yuanxia Sun,, and Yanhe Ma. 2014. Enzymatic conversion of D-galactose to D-tagatose: Cloning, overexpression and characterization of L-arabinose isomerase from Pediococcus pentosaceus PC-5 . Microbial Research. 169, Issues 2–3, 171-178. Kim P, Yoon SH, Roh HJ, Choi JH. 2001. High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase. Biotechnol. Prog .17: 208-210 (2001)
  • Charles Ling K.2008. Whey to ethanol: A biofuel role for cooperative? . Rural Business and Cooperative, program, Research report 214 February 2008. Douglas C. Elliott, Christopher F. wend, and Mikhail S, Alnajjar.2001; Lactose processing technology-Creating new utilization opportunities. 38th Annual Marshall Cheese seminar”tools for the trade.
  • Demaimay M., LeHenaff Y, and Printemps P. 1978. Hydrolysis of Lactose on catalytic Resin. Process Biochemistry 3-5.
  • Donner T.W, Wilber J.F., and Ostrowski D. 1999. D-tagatose a novel hexose: Acute effects on carbohydrate tolerance in subjects with and without type 2 diabetes. Diabetes, Obesity and metabolism 1:285-29.
  • Levin G. V. 2002. Tagatose, the new GRAS sweetener and health product. J. Med Food, 5,23-36.
  • Livesey G., Brown J.C. 1996. D-tagatose is a bulk sweetener with zero energy determined in rats. J. Nutr.126, 1601-1609.
  • Food and Drug Administration (FDA). 2004. D-tagatose.
  • Johansen H.N., and Jensen B.B. 1997. Recovery of energy as SCFA after microbial fermentation of D-tagatose. Int. J. Obes. (suppl.2) 21:S50 (abs).
  • Buemann B, Toubro S, and Astrup A. 1998. Tagatose a stereoisomer of D-tagatose a stereoisomer of D-fructose, increases hydrogen production in human without affecting 24-hour energy expenditure of respiratory exchange ratio. J. Nutr. 128:1481-1486.
  • Lu Y. G. V Levin, and T.W. Donner. 2008. Tagatose, a new antidiabetic and obesitycontrol Drug, diabetes, Obesity, and Metabolism 10: 109-134.
  • Buemann B, Gesmar H., Astrup A, and Quistorff B. 2000. Effects of oral D-tagatose, a stereoisomer of D-fructose, on liver metabolism in man as examined by 3 PMRS. Metabolism 49:1335-1339.
  • Espinosa I., and Fogelfeld L. 2010. Tagatose; from sweetener to a new diabetic medication? Expert Opin Investig Drugs 19: 285-294. Bar A. 2000. Dossier prepared on behalf of Arla Food ingredients amba, Viby, Denmark for safety assessment of D-tagatose by a panel of independent experts. Cited in GRN 000078.
  • Food and Drug Administration (FDA). 2003. Food labeling. Health claims. D-tagatose and dental caries. Final rule. Fed Reg. .68:39831-39833. Bar A. 2004. Tagatose: Food Scientific Regulatory Service. Bioresco.
  • Buemann B., Toubro S., Holst J. J., Rehfeld J., and Astrup A. 1999. D-tagatose stereoisomer of D-fructose , increases blood uric acid concentration . Metabolism 49: 969-976.
  • Marta W., and Jozef K. 2012. A method for the production of D-tagatose a recombinant Pichia pastoris strain secreting B-DD-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp.22cMicrob.Cell Fact. 11-13.
  • Yan Men, Yueming Zhu, Lili Zhang, , Zhenkui Kang, Ken Izumori,, Yuanxia Sun,, and Yanhe Ma. 2014. Enzymatic conversion of D-galactose to D-tagatose: Cloning, overexpression and characterization of L-arabinose isomerase from Pediococcus pentosaceus PC-5 . Microbial Research. 169, 2–3, 171-178.
  • Kim P, Yoon SH, Roh HJ, Choi JH. 2001. High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase. Biotechnol. 17, 208-210.
There are 27 citations in total.

Details

Primary Language English
Subjects Food Engineering
Journal Section Food Health and Technology Innovations
Authors

Osama Ibrahim This is me

Publication Date March 4, 2018
Published in Issue Year 2018 Volume: 1 Issue: 1

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