Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi

Sait Tan; Pelin Demir; Ali Arslan

Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi

Öz

Bisfenol A, polikarbonat plastiklerin ve epoksi reçinelerin üretiminde kullanılan en tehlikeli kimyasallardandır. Gıda sanayinde kullanılan plastik ve konserve gibi gıda ambalaj materyalleri de yüksek oranda Bisfenol A içermektedir. Bisfenol A, endokrin sistem bozucu, toksik, teratojenik, karsinojenik, mutajenik ve östrojenik etkilere sahip olup insan ve hayvan sağlığını önemli ölçüde etkilemektedir. Gerek ülkemizde gerekse dünya otoritelerince günlük alımına sınırlamalar getirilen Bisfenol A’nın bugün üretimi 8 milyon tonu bulmuştur. Bu derlemede Bisfenol A’nın gıda sektöründe ve halk sağlığı açısından önemi hakkında bilgi verilecektir

Anahtar Kelimeler

Kaynakça

[1] Battal D. Mersin ilinde yaşayan bireylerdeki bisfenol A düzeyinin belirlenmesi.Yüksek Lisans tezi, Mersin Üniversitesi Sağlık Bilimleri Enstitüsü, Mersin, Türkiye, 2012.
[2] Denizli A, Yavuz H. İnsan Sağlığı için olası bir tehdit: Bisfenol A Bilim Teknik Dergisi Eylül 2015; 40-42.
[3] Anonymous, 2017. National Institute of Advanced Industrial Science and Technology Bisphenol A (BPA) Risk Assessment Document.https://unit.aist.go.jp/riss/crm/mainmenu.20.04.2017.
[4] Mıljadi P. Bisphenol A. https://tr.scribd.com/document/106324822/Bisphenol-A 20.04.2017.
[5] Food Drug and Adminisration FDA. Bisphenol A. https://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients 20.04.2017.
[6] Er B. Ton balığı konservelerinde katı faz ekstraksiyon ve hplc metodu ile bisfenol A varlığının incelenmesi. Doktora Tezi, Ankara Üniversitesi, Sağlık Bilimleri Enstitüsü, Ankara, Türkiye, 2010.
[7] Tzatzarakis MN, Karzi V, Vakonaki E, et al. Bisphenol A in soft drinks and canned foods and data evaluation, Food Additives & Contaminants 2016; 1-6.
[8] Gorini F, Bustaffa E, Coi A, Iervasi G, Bianchi F, Bisphenols as environmental triggers of thyroid dysfunction: clues and evidence. Int. J. Environ. Res. Public Health 2020; 17(8): 2654. https://doi.org/10.3390/ijerph17082654.

[9] Kim JJ, Kumar S, Kumar V, Lee YM, Kim YS, Kumar V. Bisphenols as a legacy pollutant, and their effects on organ vulnerability. Int. J. Environ. Res. Public Health 202;, 17(1): 112. https://doi.org/10.3390/ijerph17010112.
[10] Anonymous, 2010. Report of Joint FAO/WHO Expert Meeting 2-5 November 2010 and Report of Stakeholder Meeting on Bisphenol A 1 November 2010 Ottawa, CanadToxicological and Health Aspects of Bisphenol A 2010.
[11] EFSA (European Food Saftey Authority), 2013. Public Consultation on the Draft Opinion on Bisphenol A (BPA) - Exposure Assessment [314 Pages]. European Food Safety Authority [Accessed 23 August 2013]. http://www.efsa.europa.eu/en/ consultations/call/130725.Htm.
[12] FAO/WHO (Food and Agriculture Organization and World Health Organization), 2011.
[13] NTP (US National Toxicology Program), 2008. In: CERHR (Ed.), NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol
[14] EFSA, Bisphenol A http://www.efsa.europa.eu/en/topics/topic/bisphenol 20.04.2017
[15] National Pivonello C, Muscogiuri G, Nardone A, Garifalos F, Provvisiero DP, Verde N, de Angelis C, Conforti A, Piscopo M, Auriemma RS, Colao A, Pivonello R. Bisphenol A: an emerging threat to female fertility. Reproductive Biology and Endocrinology 2020 Mar 14;18(1):22. https://doi.org/10.1186/s12958-019-0558-8.
[16] Wu W, Li M, Liu A, Wu C, Li D, Deng Q, Zhang B, Du J, Gao X, Hong Y, 2020. Bisphenol A and the risk of obesity a systematic review with meta-analysis of the epidemiological evidence. Dose Response 2020; 18 (2): 1-10. https://doi.org/10.1177/1559325820916949.
[17] Zwierello W, Maruszewska A, Skorka-Majewicz M, Goschorska M, Baranowska-Bosiacka I, Dec K, Styburski D, Nowakowska A, Gutowska I. The influence of polyphenols on metabolic disorders caused by compounds released from plastics - Review. Chemosphere 2020; 240: 124901.
[18] Merchant Research (2017). Bisphenol a (BPA): 2017 world market outlook and forecast up to 2027. https://mcgroup.co.uk/researches/bisphenol-a-bpa, Accessed date: 16 November 2017.
[19] Vilarinhoa F, Sendón R, Van der Kellen A, Vaz MF, Sanches Silva A. Bisphenol A in food as a result of its migration from food packaging. Trends in Food Science & Technology 2019; 91: 33-65.
[20] Pedersen, G. A., Hvilsted, S., & Petersen, J. H. (2015). Migration of bisphenol A from polycarbonate plastic of different qualities: Environmental project No. 1710 , 2015. Danish Ministry of the Environment. Miljoeprojekter No. 1710 http://mst.dk/service/publikationer/publikationsarkiv/2015/maj/migration-of-bisphenol-a-frompolycarbonate-plastic. [21] FDA, Bisphenol A (BPA): Use in Food Contact Application. https://www.fda.gov/newsevents/publichealthfºCus/ucm064437.htm 20.04.2017.
[22] Lorber M, Schecter A, Paepke O, Shropshire W, Christensen K, Birnbaum L. Exposure assessment of adult intake of bisphenol A (BPA) with emphasis on canned food dietary exposures. Environment International 2015a; 77: 55-62. https://doi.org/ 10.1016/j.envint.2015.01.008.
[23] Kang JH, Katayama Y, Kondo F. Biodegradation or Metabolism of Bisphenol A from mikroorgnism to mammals. Toxicology 2006; 217: 81-90.
[24] Nakanishi J, Miyamoto KI, Kawasaki H. Bisphenol A Risk Assessment Document, AIST Risk Assessment Document 2007; Series No. 4.
[25] National Center for Biotechnology Information. PubChem Compound Database; CID=6623, https://pubchem.ncbi.nlm.nih.gov/compound/6623 (accessed Apr. 27, 2017).
[26] Anonymous, Occupational Safety and Health Administration Bisphenol A https://www.osha.gov/dts/chemicalsampling/data/CH_221000.html 20.04.2017.
[27] Cwiek-Ludwicka K. Bisphenol A (BPA) in food contact materials - new scientific opinion from EFSA regarding public health risk. Roczniki Państwowego Zakładu Higieny 2015: 66(4):299-307
[28] Tox Town. Bisfenol A, https://toxtown.nlm.nih.gov/text_version/chemicals.php, 27.04.2017.
[29] The Environmental Working Group, Bisphenol A- toxic plastics chemical in canned food http://www.ewg.org/research/bisphenol 20.04.2017.
[30] Pielichowski K, Michalowski S. (2014). Nanostructured flame retardants: Performance, toxicity, and environmental impact. Polymer Nancomposites and Other Materials Containing Nanoparticles 2014; 251-277. https://doi.org/10.1533/9780857096678.3.251.
[31] EFSA (2015a). No consumer health risk from bisphenol A exposure. http://www.efsa.europa.eu/en/press/news/150121, Accessed date: 7 November 2017.
[32] Hoekstra EJ, Simoneau C. Release of Bisphenol A from Polycarbonate-A Review, Critical Reviews in Food Science and Nutrition 2013; 53(4): 386-402.
[33] Joint Fao/WHO Expert Meeting (2010). Toxicological and health aspects of bisphenol a Joint. Ottawa, Canada: World Health Organization.
[34] Health Canada, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Survey of Bisphenol A in Canned Drink Products (2009): 1-8.
[35] Janet R. Concerned about BPA: Check your receipts https://www.sciencenews.org/blog/science-public 20.04.2017.
[36] Akyüz S, Yarat A, Egil E. Bisfenol-A içerikli dental materyallere güncel yaklaşım. Marmara Üniversitesi Diş Hekimliği Fakültesi MÜSBED 2011; 1(3): 190-195.
[37] Altuntaş Ü. Türkiye’de satışa sunulan bazı gıdalarda ambalaj materyallerinden migrasyonun ölçülmesi. Yüksek Lisans Tezi, Istanbul Teknik Üniversitesi Fen Bilimleri Enstitüsü, İstanbul, Türkiye, 2014.
[38] Yavuz HT. Migration of dipropylene and tripropylene glycol diacrylate from packaging materials and screening of potential risks in paper packagings. MSc, Istanbul Technical University Graduate School of Science Engineering And Technology, İstanbul, Turkey, 2013.
[39] Barnes KA, Sinclair CR, Watson DH. Chemical Migration and Food Contact Materials 2007; Chapter 1: 1-12.
[40] Cao XL, Corriveau J. Migration of Bisphenol A from polycarbonate baby and water bottles into water under severe condition. J. Agric. Food Chem. 2008; 56: 6378-6381.
[41] Sungur Ş. Köroğlu M, Özkan A. Determination of bisphenol a migrating from canned food and beverages in markets. Food Chemistry 2014; 142: 87-91.
[42] Nam SH, Seo YM, Kim MG, Bisphenol A Migration from polycarbonate baby bottle with repeated use. Chemosphere 2010; 79: 949-952.
[43] Ye X, Wong LY, Bishop AM, et al. Variability of Urinary Concentrations of Bisphenol A in Spot Samples, First Morning Voids, and 24-Hour Collections Environ Health Perspect 2011; 119: 983-988.
[44] Michalowicz J. Bisphenol A-Sources toxicity and Biotransformation. Environmental Toxicology and Pharmacology 2014; 37: 738-758.
[45] EFSA (2015b). Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs. EFSA Journal, 13(1), 1-621. https://doi.org/10.2903/j.efsa.2015.3978nih.gov/health/topics/agents/sya-bpa/index.cfm. 20.04.2017.
[46] Rykowska I, Wasiak W. Properties, Threats and methods of analysis of bisphenol A and its derivatives. Acta Chromatographica 2006; 16: 7-20.
[47] Ferrer E, Santoni E, Vittori S, Font G, Mañes J, Sagratini G. Simultaneous determination of bisphenol A, Octylphenol, and nonylphenol by pressurised liquid extraction and liquid chromatography-tandem mass spectrometry in powdered milk and infant formulas. Food Chemistry 2011; 126(1): 360-367. https://doi.org/10.1016/j. foodchem.2010.10.098.
[48] Keller and Heckman LLP, France Releases Guidance on BPA Ban and Food-Contact Legislation, http://www.packaginglaw.com/news/france-releases-guidance-bpa-ban-and-food-contact-legislation 20.04.2017.
[49] Food Standards. Australia New Zealand, Regulation and monitoring of BPA http://www.foodstandards.gov.au/consumer/chemicals/bpa/pages/regulationandmonitor5377.aspx. 20.04.2017.
[50] Regulation (EU) 2018/213 (2018). Official Journal of the European Union L41/6-12. [51] T.C. Gıda Tarım ve Hayvancılık Bakanlığı, Türk Gıda Kodeksi http://www.tarim.gov.tr/Mevzuat/Turk-Gida-Kodeksi 20.04.2017.
[52] National Institute of Environmental Health Sciences, Bisphenol A (BPA) https://www.niehs.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Sait Tan
0000-0002-8596-9261
Türkiye

Pelin Demir ^*
0000-0002-0824-1672
Türkiye

Ali Arslan
0000-0002-3011-5592
Türkiye

Yayımlanma Tarihi

27 Mart 2022

Gönderilme Tarihi

6 Eylül 2021

Kabul Tarihi

15 Kasım 2021

Yayımlandığı Sayı

Yıl 2022 Cilt: 34 Sayı: 1

IZ

https://izlik.org/JA56RN24NZ

Kaynak Göster

RIS / Bibtex

APA

Tan, S., Demir, P., & Arslan, A. (2022). Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi. Fırat Üniversitesi Fen Bilimleri Dergisi, 34(1), 11-17. https://izlik.org/JA56RN24NZ

AMA

1.Tan S, Demir P, Arslan A. Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi. Fırat Üniversitesi Fen Bilimleri Dergisi. 2022;34(1):11-17. https://izlik.org/JA56RN24NZ

Chicago

Tan, Sait, Pelin Demir, ve Ali Arslan. 2022. “Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi”. Fırat Üniversitesi Fen Bilimleri Dergisi 34 (1): 11-17. https://izlik.org/JA56RN24NZ.

EndNote

Tan S, Demir P, Arslan A (01 Mart 2022) Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi. Fırat Üniversitesi Fen Bilimleri Dergisi 34 1 11–17.

IEEE

[1]S. Tan, P. Demir, ve A. Arslan, “Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi”, Fırat Üniversitesi Fen Bilimleri Dergisi, c. 34, sy 1, ss. 11–17, Mar. 2022, [çevrimiçi]. Erişim adresi: https://izlik.org/JA56RN24NZ

ISNAD

Tan, Sait - Demir, Pelin - Arslan, Ali. “Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi”. Fırat Üniversitesi Fen Bilimleri Dergisi 34/1 (01 Mart 2022): 11-17. https://izlik.org/JA56RN24NZ.

JAMA

1.Tan S, Demir P, Arslan A. Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi. Fırat Üniversitesi Fen Bilimleri Dergisi. 2022;34:11–17.

MLA

Tan, Sait, vd. “Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi”. Fırat Üniversitesi Fen Bilimleri Dergisi, c. 34, sy 1, Mart 2022, ss. 11-17, https://izlik.org/JA56RN24NZ.

Vancouver

1.Sait Tan, Pelin Demir, Ali Arslan. Bisfenol A (BFA) ve Halk Sağlığı Açısından Önemi. Fırat Üniversitesi Fen Bilimleri Dergisi [Internet]. 01 Mart 2022;34(1):11-7. Erişim adresi: https://izlik.org/JA56RN24NZ