Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis?

Year 2023, Volume: 33 Issue: 3, 305 - 308, 30.06.2023

Savaş Karpuz , Ramazan Yılmaz , Mehmet Özkan , İsmail Hakkı Tunçez , Eser Kalaoğlu , Halim Yılmaz

https://doi.org/10.54005/geneltip.1228775

Abstract

Objective:The purpose of this study is to investigate the utility of systemic immune inflammation index as a predictor of disease severity in patients with knee osteoarthritis.
Methods: 200 patients diagnosed with knee osteoarthritis according to ACR knee osteoarthritis diagnostic criteria were included in the study. Kellgren-Lawrence staging of knee osteoarthritis, Western Ontario and McMaster University Osteoarthritis (WOMAC) index score and systemic immune-inflammation index score were calculated among all participants
Results: There were 152 (%76) female and 48 (%24) male participants and median score of age was 63 (54,25-70). 14 (7%) grade 1 gonarthrosis, 64 (32%) grade 2, 72 (36%) grade 3 and 50 (25%) grade 4 gonarthrosis patients were detected. There was no significant correlation between the systemic immune-inflammation index and the radiological stage of gonarthrosis (Kellgren Lawrens Score) (p=0.238). No statistically significant correlation was found between the systemic immune-inflammation index and WOMAC scores (p=0.593).
Conclusion: The systemic immune-inflammation index was not found to be correlated with disease severity in knee OA.

Keywords

Knee osteoarthritis, inflammation mediators, disease severity, systemic immune-inflammation index

Supporting Institution

none

Diz Osteoartritinde Sistemik İmmün İnflamatuar İndeks Hastalık Şiddeti ile Alakalı mıdır?

Abstract

Amaç: Bu çalışmanın amacı diz osteoartiriti olan hastalarda sistemik immün enflamasyon indeksinin hastalık şiddetinin belirleyicisi olarak kullanılabilirliği araştırmaktır.
Yöntem: Çalışmaya ACR diz osteoarttriti tanı kriterlerine göre gonartroz tanısı almış 200 hasta çalışmaya dahil edildi. Tüm katılımcıların diz osteoartriti Kellgren-Lawrence evrelendirmesi, Western Ontario ve McMaster Üniversitesi Osteoartrit(WOMAC) indeksi skoru ve sistemik immün-enflamasyon indeksi belirlendi.
Bulgular: Katılımcıların 152’si (%76) kadın 48’si (%24) erkek ve yaş medianı 63 (54,25-70) idi. Katılımcılardan 14 (%7) kişide evre 1, 64 (%32) kişide evre 2, 72 kişide (%36) evre 3 ve 50 (%25) kişide evre 4 gonartroz tespit edildi. Sistemik immün-enflamasyon indeksi ile gonartroz radyolojik evresi (Kellgren Lawrens Skoru) arasında anlamlı ilişki tespit edilmedi (p=0,238). Sistemik immün-enflamasyon indeksi ile WOMAC skorları arasında istatistiksel anlamlı korelasyon tespit edilmedi (p=0,593).
Sonuç: Sistemik immün-enflamasyon indeksi diz OA’inde hastalık şiddeti ile körele olmadığı tespit edilmiştir.

Keywords

Diz osteoartriti, Enflamasyon mediatörleri, Hastalık şiddeti, Sistemik immün inflamatuar indeks, Knee osteoarthritis, inflammation mediators, disease severity, systemic immune-inflammation index

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