Is There Any Correlation Between the Systemic Immune Inflammatory Index and Disease Severity in Knee Osteoarthritis?

Yıl 2023, Cilt: 33 Sayı: 3, 305 - 308, 30.06.2023

Savaş Karpuz , Ramazan Yılmaz , Mehmet Özkan , İsmail Hakkı Tunçez , Eser Kalaoğlu , Halim Yılmaz

https://doi.org/10.54005/geneltip.1228775

Öz

Objective:The purpose of this study is to investigate the utility of systemic immune inflammation index as a predictor of disease severity in patients with knee osteoarthritis.
Methods: 200 patients diagnosed with knee osteoarthritis according to ACR knee osteoarthritis diagnostic criteria were included in the study. Kellgren-Lawrence staging of knee osteoarthritis, Western Ontario and McMaster University Osteoarthritis (WOMAC) index score and systemic immune-inflammation index score were calculated among all participants
Results: There were 152 (%76) female and 48 (%24) male participants and median score of age was 63 (54,25-70). 14 (7%) grade 1 gonarthrosis, 64 (32%) grade 2, 72 (36%) grade 3 and 50 (25%) grade 4 gonarthrosis patients were detected. There was no significant correlation between the systemic immune-inflammation index and the radiological stage of gonarthrosis (Kellgren Lawrens Score) (p=0.238). No statistically significant correlation was found between the systemic immune-inflammation index and WOMAC scores (p=0.593).
Conclusion: The systemic immune-inflammation index was not found to be correlated with disease severity in knee OA.

Anahtar Kelimeler

Knee osteoarthritis, inflammation mediators, disease severity, systemic immune-inflammation index

Destekleyen Kurum

none

Diz Osteoartritinde Sistemik İmmün İnflamatuar İndeks Hastalık Şiddeti ile Alakalı mıdır?

Öz

Amaç: Bu çalışmanın amacı diz osteoartiriti olan hastalarda sistemik immün enflamasyon indeksinin hastalık şiddetinin belirleyicisi olarak kullanılabilirliği araştırmaktır.
Yöntem: Çalışmaya ACR diz osteoarttriti tanı kriterlerine göre gonartroz tanısı almış 200 hasta çalışmaya dahil edildi. Tüm katılımcıların diz osteoartriti Kellgren-Lawrence evrelendirmesi, Western Ontario ve McMaster Üniversitesi Osteoartrit(WOMAC) indeksi skoru ve sistemik immün-enflamasyon indeksi belirlendi.
Bulgular: Katılımcıların 152’si (%76) kadın 48’si (%24) erkek ve yaş medianı 63 (54,25-70) idi. Katılımcılardan 14 (%7) kişide evre 1, 64 (%32) kişide evre 2, 72 kişide (%36) evre 3 ve 50 (%25) kişide evre 4 gonartroz tespit edildi. Sistemik immün-enflamasyon indeksi ile gonartroz radyolojik evresi (Kellgren Lawrens Skoru) arasında anlamlı ilişki tespit edilmedi (p=0,238). Sistemik immün-enflamasyon indeksi ile WOMAC skorları arasında istatistiksel anlamlı korelasyon tespit edilmedi (p=0,593).
Sonuç: Sistemik immün-enflamasyon indeksi diz OA’inde hastalık şiddeti ile körele olmadığı tespit edilmiştir.

Anahtar Kelimeler

Diz osteoartriti, Enflamasyon mediatörleri, Hastalık şiddeti, Sistemik immün inflamatuar indeks, Knee osteoarthritis, inflammation mediators, disease severity, systemic immune-inflammation index

Kaynakça

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