Wnt/Beta-katenin Sinyal Yolunun Preimplantasyon, İmplantasyon, Desidualizasyon ve Plasentasyondaki Kritik Rolü

Yıl 2025, Cilt: 6 Sayı: 1, 74 - 84, 29.05.2025

Hanife Güler Dönmez , M.sinan Beksac

https://doi.org/10.63716/guffd.1617231

Öz

Embriyo ve maternal faktörler arasındaki sıkı ilişki sağlıklı bir gebelik süreci için oldukça önemlidir. Bu noktada uterus, sağlıklı bir embriyonun gelişimine devam etmesi ya da ortadan kaldırılması için embriyoyu indüklerken, embriyo endometriyuma tutunmaya, endometriyum içine yayılmaya ve maternal immünolojik etkilere karşı hayatta kalmaya çalışmaktadır. İmplantasyon, desidual reaksiyon ve plasentasyon olayları çok sayıda sinyal yolunun birbirleri ile etkileştiği kompleks bir süreçle kontrol edilmektedir. Wnt/beta-katenin sinyal yolu da bu gelişimsel olaylarda rol oynadığı belirlenen evrimsel olarak korunmuş bir sinyal yoludur. Son bulgular, Wnt/beta-katenin sinyalindeki anormalliklerin implantasyon başarısızlığı, anormal plasenta gelişimi ve preeklampsi gibi üreme bozukluklarına katkıda bulunabileceğini göstermektedir. Bu sebeple derlememizde erişkin ve embriyonik dönemde hücre proliferasyonu, farklılaşması, adezyonu ve hücre göçü gibi çeşitli biyolojik süreçlerdeki etkisi olan Wnt/beta-katenin sinyal yolunun preimplantasyon, implantasyon, desidual reaksiyon ve plasentasyondaki rolünün literatür bilgileri eşliğinde açıklanması ve ortaya konulması amaçlanmıştır. Böylece bu derleme, Wnt/beta-Katenin sinyal yolunun üreme sürecindeki kritik rolünü daha iyi anlamamıza katkı sağlayarak, bu yoldaki bozukluklarla ilişkili komplikasyonların tanı ve tedavisinde yeni stratejilerin geliştirilmesine ışık tutmayı amaçlamaktadır.

Anahtar Kelimeler

İmplantasyon, Desidualizasyon, Plasentasyon, Wnt/beta-katenin sinyal yolu

Kaynakça

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