Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler

Yıl 2025, Cilt: 6 Sayı: 2, 343 - 374, 29.11.2025

Tuğba Topal , Zehra Ece Uzun

https://doi.org/10.63716/guffd.1768168

Öz

Son yıllarda, immün hücrelerin tümör organoidleri ile birlikte kültürlenmesine yönelik artan bir ilgi bulunmaktadır. Bu yaklaşım, tümörler ile immün sistem arasındaki karmaşık etkileşimlere dair önemli bilgiler elde edilmesini sağlamıştır. Bu çalışmada, tümör mikro çevresi içerisinde yer alan immün hücrelerle olan etkileşimlerin modellenmesine yönelik olarak geliştirilen tümör–immün sistem hücresi organoidlerine dair mevcut gelişmeler ele alınmaktadır. Tümörün oluşumu, tümör mikro çevresinin temel bileşenleri ve bu çevrede yer alan başlıca immün hücre türleri hakkında genel bir çerçeve sunulmuştur. Özellikle hücre dışı matriksin biyokimyasal ve mekanik özelliklerinin; hücreler arası sinyalleşme, hücre göçü ve immün hücrelerin tümöre erişimi üzerindeki etkileri değerlendirilmektedir. Üç boyutlu kültür yöntemleriyle oluşturulan organoid modellerin geliştirilmesi, hastadan türetilmiş örneklerin kullanımı ve organ-on-a-chip gibi ileri teknolojilere dayalı yaklaşımlar sayesinde, tümör–immün sistem etkileşimlerinin daha fizyolojik koşullarda modellenmesi mümkün hale gelmektedir. Son olarak, bu modellerin klinik araştırmalarda kullanımı, tümör biyolojisinin anlaşılmasına katkıları ve gelecekteki potansiyel uygulama alanları tartışılmaktadır.

Anahtar Kelimeler

Tümör mikroçevresi , Çip üzerinde organoid teknolojisi , Hücre dışı matris. , Tümör mikroçevresi , Organoid , Biyomedikal Muhendisligi

Kaynakça

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