Remote work, which was seen as a fashionable word in the pre-Covid-19 periods, has been the main focus of their lives as a flexible working arrangement, which has been introduced as the "new normal" that millions of employees had to pass overnight since March 2020, and employees must adapt quickly. People who work in the uncertain and chaotic environment created by the epidemic are faced with increasing levels of job insecurity, which indicates not only the loss of one's job but also the loss of various job characteristics that they want to protect with remote working arrangements. In this direction, event systems, boundary and conservation of resource theories constitute the theoretical background of the study. This study, based on the relevant theories, examines the moderating role of work-life balance and the mediating role of psychological security in the effect of remote work effectiveness on job insecurity. As a result of the survey conducted by 444 white-collar employees from the service and manufacturing sectors, the findings reveal that psychological security mediates the relationship between the effectiveness of working remotely and job insecurity, work-life balance increases the indirect positive effect of remote work effectiveness on the employees' psychological safety, and as work-life balance increases, this indirect effect also increases.