Novel Methyl 4,6-O-Benzylidene--D-Glucopyranoside Derivatives: Synthesis, Structural Characterization and Evaluation of Antibacterial Activities

Year 2019, Volume: 47 Issue: 2, 153 - 164, 18.09.2019

Mirajul Islam Arifuzzaman Arifuzzaman Monjur Rahman Mohammad Atiar Rahman Sarkar Mohammad Abe Kawsar Kawsar

https://doi.org/10.15671/hjbc.622038

Cited By: 25

Abstract

Carbohydrates are the most abundant and the most diverse biopolymers in nature. Due to the importance of carbohydrates it is necessary to develop a new method for the synthesis of carbohydrate based drugs of the current global situation for health and disease. In this present work we demonstrate the synthesis of methyl 4,6-O-benzylidene--Dglucopyranoside derivatives by direct acylation method. The structures of the newly prepared compounds have been characterized and elucidated using various physico-chemical and spectroscopic methods including elemental analysis, melting point determination, infrared and proton NMR spectroscopy. A number of acyl derivatives were prepared in order to obtain a series of newer components for antibacterial screening experiments. These acylated derivatives were evaluated for in vitro antibacterial screening studies against four human pathogenic bacteria by disc diffusion method.

Keywords

Synthesis, benzylidene, acylation, structure, pathogens

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