Rare Side Effect of Immune Checkpoint Inhibitors: Adrenal Insufficiency

Abstract

Summary Immune checkpoint inhibitors are cell membrane proteins that regulate the immune response. It is used in the treatment of non-small cell lung cancer, renal cell carcinoma, melanoma and some other tumor types. They affect the dermatological, gastrointestinal, hepatic, endocrine and other systems. We present a case of adrenal insufficiency caused by nivolumab in a patient presenting with complaints of weakness, fatigue, nausea and vomiting.

Keywords

• Adrenal insufficiency
• Nivolumab
• Immune checkpoint inhibitors

İmmün Checkpoint İnhibitörlerinin Nadir Yan Etkisi: Adrenal Yetmezlik

Abstract

Amaç: İmmün kontrol noktası inhibitörleri immun yanıtı düzenleyen hücre zar proteinleridir. Küçük hücreli dışı akciğer kanseri, renal hücreli karsinom, melanom ve diğer bazı tümör tiple-rinin tedavisinde kullanılmaktadır. Dermatolojik, gastrointestinal, hepatik, endokrin ve diğer sistemleri etkilerler. Halsizlik, yorgunluk, bulantı ve kusma şikâyetleri ile başvuran bir hasta-da nivolumabın neden olduğu adrenal yetmezlik olgusunu sunuyoruz.

Keywords

• Adrenal yetmezlik
• Nivolumab
• İmmün checkpoint inhibitörleri

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