Tip 2 Diyabetli Yaşlı Hastalarda El Kavrama Gücü ile Hematolojik Belirteçler Arasındaki İlişki

Abstract

Amaç: Bu çalışmada, tip 2 diabetes mellitus (T2DM) tanılı yaşlı bireylerde inflamatuvar ve hematolojik parametreler ile el sıkma gücü (ESG) arasındaki ilişkiyi değerlendirmek amaçlandı. Materyal ve metod: Toplam 227 hasta çalışmaya dahil edildi. ESG, European Working Group on Sarcopenia in Older People 2 kriterlerine göre değerlendirildi ve beyaz küre sayısı (BKS), nötrofil sayısı (NS), lenfosit sayısı (LS), ortalama trombosit hacmi (OTH), trombosit dağılım genişliği (TDG), eritrosit dağılım genişliği (EDG), C-reaktif protein (CRP) ve glike hemoglobin (HbA1c) ile ilişkilendirildi. Veriler SPSS sürüm 27.0 (IBM Corp., Armonk, NY, ABD) kullanılarak analiz edildi. Bulgular: Çalışma grubunu 85 kadın ve 142 erkek oluşturdu (ortalama yaş 70,2±4,9 yıl). Düşük ESG, 82 hastada gözlendi ve CRP ile güçlü bir korelasyon gösterdi (r=-0,504, p<0,001). BKS, NS, LS, nötrofil/lenfosit oranı ile EDG ve TDG de düşük HSG ile ilişkili bulundu. Buna karşılık, Mini Mental Durum Muayenesi, Katz Günlük Yaşam Aktiviteleri Bağımsızlık İndeksi, Lawton-Brody Enstrümantal Günlük Yaşam Aktiviteleri, Geriatrik Depresyon Ölçeği ve HbA1c ile anlamlı ilişki saptanmadı. Daha düşük Tinetti skorları ve daha uzun Zamanlı Kalk ve Yürü testi süreleri, azalmış ESG ile anlamlı şekilde ilişkiliydi. Lojistik regresyon analizinde düşük ESG için bağımsız öngördürücüler arasında OTH (OR=2.956, %95 GA=1.630-5.350, p<0,001) ve EDG (OR=0,549, %95 GA=0,360-0,850, p=0,007) öne çıkarken, ek olarak NS, LS ve CRP de istatistiksel olarak anlamlı bulundu. Sonuç: ESG, inflamatuvar ve hematolojik parametrelerle yakından ilişkilidir ve bulgular T2DM’li yaşlı bireylerde fiziksel fonksiyonun basit ve değerli bir göstergesi olarak kullanılabileceğini desteklemektedir.

Keywords

• Kapsamlı geriatrik değerlendirme
• El sıkma gücü
• Inflammation
• Yaşlı
• Type-2 diabetes mellitus

Relationship between Handgrip Strength and Hematological Markers in Older Adult Patients with Type 2 Diabetes Mellitus

Abstract

Background: This study evaluated the relationship between inflammatory and hematological parameters and handgrip strength (HGS) in older adults with type 2 diabetes mellitus (T2DM). Materials and Methods: 227 patients were enrolled in the study. HGS was assessed according to the European Working Group on Sarcopenia in Older People 2 criteria and analyzed against white blood cell count (WBC), neutrophil count (NC), lymphocyte count (LC), mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), C-reactive protein (CRP), and glycated hemoglobin (HbA1c). Datawere analyzed with SPSS version 27.0. Results: The cohort included 85 women and 142 men (meanage 70.2±4.9 years). Low HGS was observed in 82 patients andwas strongly correlated with CRP (r=-0.504, p<0.001). WBC, NC,LC, neutrophil-to-lymphocyte ratio, RDW, and PDW were alsoassociated, while Mini-Mental Status Examination, Katz Indexof Independence in Activities of Daily Living, Lawton-BrodyInstrumental Activities of Daily Living, Geriatric Depression Scale,and HbA1c were not. Lower Tinetti scores and longer Timed Upand Go times correlated with reduced HGS. In logistic regressionanalysis, MPV (OR=2.956, 95% CI=1.630-5.350, p<0.001) andRDW (OR=0.549, 95% CI=0.360-0.850, p=0.007) emerged as thestrongest independent predictors of low HGS, while NC, LC, andCRP also reached statistical significance. Conclusions: HGS is closely associated with inflammatory andhematological markers, supporting its role as a simple indicator ofphysical function in older adults with T2DM.

Keywords

• Comprehensive geriatric assessment
• Handgripstrength
• Inflammation
• Older adult
• Type-2 diabetes mellitus

Ethical Statement

This study was approved by the Non-Interventional Clinical Research Ethics Committee of Gaziantep Islam Science and Technology University (approval no: 650.48.24, date: June 18, 2025).

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