Evaluation of the Relationship Between Uric Acid Levels and Etiology in Patients With Heart Failure

Year 2019, Volume: 16 Issue: 3, 478 - 483, 25.12.2019

Fatih Güngören , Feyzullah Beşli

https://doi.org/10.35440/hutfd.642972

Abstract

Background: Uric
acid is the final product of purine metabolism in humans, and its relationship
with cardiovascular diseases has been investigated in many studies. However,
there are limited studies evaluating serum uric acid levels in patients with
ischemic and dilated cardiomyopathy. The aim of this study is to compare serum
uric acid levels in patients with ischemic (ICMP) and dilated cardiomyopathy
(DCMP).

Methods: A total of 115
patients with low ejection fraction heart failure who were admitted to our
clinic between January 2016 and June 2018 and 55 age-sex matched control were
included in this study. Patients with low ejection fraction heart failure were
divided into two groups as follows: ICMP (n = 69) and DCMP (n = 46).

Results: There was no
statistically significant difference between ICMP and DCMP groups in terms of
gender, body mass index, used drugs and frequency of arrhythmias. However, age,
the frequency of hypertension, hyperlipidemia, coronary artery disease (CAD),
history of familial CAD and smoking were significantly higher in ICMP group.
When both groups were compared in terms of laboratory characteristics, it was
found observed that uric acid value was significantly higher in ICMP group (6.9
± 1.9 vs. 6.3 ± 1.2, p=0.029).

Conclusion: In
our study, it was found that serum uric acid level was significantly higher in
heart failure patients with ICMP compared to patients with DCMP.

Kalp Yetersizliği Hastalarında Ürik Asit seviyeleri ile Etiyoloji arasındaki İlişkinin Değerlendirilmesi

Abstract

Amaç: Ürik
asit, insanlarda pürin metabolizması sonucunda meydana gelen son üründür ve pek
çok çalışmada kardiyovasküler hastalıklar ile ilişkisi incelenmiştir. Ancak, iskemik
ve dilate kardiyomiyopati hastalarında serum ürik asit seviyelerinin
değerlendirildiği çalışmalar sınırlıdır. Çalışmamızın amacı, iskemik (İKMP) ve
dilate kardiyomiyopati (DKMP) hastalarında serum ürik asit seviyelerini
karşılaştırmaktır.

Materyal ve Metod: Bu
çalışmaya kliniğimizde Ocak 2016 ile Haziran 2018 tarihleri arasında düşük
ejeksiyonfraksiyonlu kalp yetersizliği nedeniyle yatmış olan 115 hasta ve
yaş-cinsiyet eşleştirmesi yapılan 55 kontrol hastası alındı. DEFKY’li hastalar
İKMP olanlar (n=69) ve DKMP olan hastalar (n=46) olarak iki gruba ayrıldı.

Bulgular: İKMP ve
DKMP grupları arasında; cinsiyet, vücut kitle indeksi, kullanılan ilaçlar ve
aritmi görülme sıklığı açısından anlamlı bir farklılık saptanmadı. Ancak, İKMP
grubunda yaş, hipertansiyon, hiperlipidemi, koroner arter hastalığı (KAH)
varlığı, ailede KAH öyküsü ve sigara içiciliği sıklığı anlamlı olarak daha
fazla idi. Her iki grup, laboratuvar özellikleri açısından
karşılaştırıldıklarında; İKMP grubunda ürik asit değerinin anlamlı olarak daha
yüksek olduğu saptandı (6.9 ± 1.9’a karşın 6.3 ± 1.2, p=0.029).

Sonuç: Çalışmamızda,
İKMP’li kalp yetersizliği hastalarında serum ürik asit düzeyinin DKMP‘li kalp
yetersizliği hastalarına göre anlamlı olarak yüksek olduğu tespit edildi.

Keywords

Kalp yetersizliği, Kardiyomiyopati

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