Normal Gelişim Gösteren Çocuklar ve Otizmli Çocuklarda Plusoptix A09 ile Ölçülen Pupil Çapı, Korneal Refleks ve İnterpupiller Mesafenin Karşılaştırılması

Abstract

Amaç: Otizm Spektrum Bozukluğu (OSB) belirtileri, otonom sinir sisteminin (ANS) anormal işleyişinden kaynaklanabilir.

Yöntem: Çalışmada 19 sağlıklı çocuk (kontrol grubu) ile 19 otizm hastasının 38 gözü dahil edildi. Her iki grubun pupil çapı, interpupiller mesafe ve korneal refleks ölçümleri analiz edildi. Ölçümlerde Plusoptix A09 marka cihaz kullanıldı.

Bulgular: Otizm grubu için ortalama yaş±standart sapma (SD) 4,6±2,5 yıl (aralık 2-11 yıl) idi. Kontrol grubu için ortalama yaş±SD 5,02±2,6 yıl (aralık 2-11 yıl) idi. Sağ gözbebeği (p=0,006) ve sol gözbebeği (p=0,007) pupil çapları kontrol ve deney gruplarında anlamlı olarak farklı bulundu. İnterpupiller mesafe (p=0,000) otistik ve kontrol gruplarında anlamlı olarak farklıydı ancak kornea refleksi, kontrol ve otistik gruplarda anlamlı farklılık göstermedi (p=0,173). Tüm istatistiksel sonuçlarda p değeri 0,5'ten küçüktür.

Sonuç: Sonuç olarak, otizmli çocukların pupil çapı ve interpupiller mesafesi kontrol grubuna göre daha büyük bulundu. Pupil ölçümleri, OSB olan ve olmayan kişiler arasındaki farklılıkları ortaya koymaktadır.

Keywords

• Otizm spektrum bozukluğu
• kornea
• refleks
• pupiller
• Autism spectrum disorders
• cornea
• reflex
• pupillary

Comparison of Interpupillary Distance, Pupillary Diameter and Corneal Reflex Measured with Plusoptix A09 in Normally Developing Children and Autism

Abstract

Aim: Autism Spectrum Disorder (ASD) is a developmental disorder that can present with an abnormality of the autonomic nervous system (ANS symptoms).

Method: In this study, 38 eyes of 19 ASD were included with 19 healthy children (control group). Participants were analyzed according to their characteristics. Here, used the Plusoptix A09 devices to measure the difference in pupil size, corneal reflex, and interpupillary distance (IPD) between ASD and healthy children.

Results: The mean age±standard deviation (SD) for the autism group was 4,6±2,5 years (range 2-11 years). In the group of normally developing children, the mean age was±SD 5,02±2,6 years (range 2-11 years). The size of the right pupil (p=0,006) and left pupil (p=0,007) was found to be significantly different in the control and experimental groups. IPD (p=0,000) was statistically significant between groups unlike the corneal reflex was not (p=0,173). The p-value is less than 0,05 in all statistical results.

Conclusion: As a result, pupil diameter and IPD of children with autism were found to be larger than the control group, but there was no significant difference in corneal reflex. Pupillary measurements reveal differences between people with ASD.  

Keywords

• Autism spectrum disorders
• cornea
• reflex
• pupillary

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