LAVANDULA ANGUSTIFOLIA MILLER UÇUCU YAĞI ÜZERİNDE FARMAKOGNOZİK ARAŞTIRMALAR

Year 2022, Volume: 10 Issue: 2, 554 - 562, 20.06.2022

Harun Kızılay Engin Şarer

https://doi.org/10.33715/inonusaglik.1094835

Abstract

Lavandula türleri sahip oldukları bileşikleri nedeni ile tedavide, parfümeride, gıda, kozmetik ve ilaç endüstrilerinde yararlanılan bitkilerdir. Araştırmanın konusu olan Lavandula angustifola Miller bitkisi, halk arasında çeşitli hastalıkların tedavisinde kullanılmaktadır. Bitkinin ülkemizde yaygın olarak kültürü yapılmaktadır. Lavandula türleri, çeşitli etken maddelerinin yanı sıra, özellikle içerdikleri uçucu yağ nedeniyle önemlidir. Lavandula angustifolia Miller diğer türlerinden daha çok ve en değerli uçucu yağa sahip olan türdür. Bunun yanında Lavandula latifolia ve Lavandula hybrida’nın uçucu yağları da ticari öneme sahiptir. Bu araştırmada bitki Isparta ili Keçiborlu ilçesinden toplanmıştır. Bitkinin çiçekli dal uçları distillenmiş ve kuru ağırlık üzerinden %3.39 (h/a) oranında uçucu yağ elde edilmiştir. L. angustifolia’dan elde edilen bu uçucu yağ, GC-MS kullanılarak analiz edilmiş olup 34 bileşik saptanmıştır. Uçucu yağda ana bileşenler olarak; linalol (%47.66), 1.8-sineol (%9.10), linalil asetat (%7.65) ve kafur (%6.46) tespit edilmiştir. Bu araştırma sonucuna göre, Lavandula angustifola örneğinden elde edilen uçucu yağ, lavandin esansına benzer kompozisyonu nedeniyle gıda, kozmetik, sabun ve ilaç endüstrileri ile fitoterapi ve aromaterapi alanında değerlendirilebilecek bir uçucu yağdır.

Keywords

Lavandula angustifolia, Lavanta esansı, Linalol, Linalil asetat

Supporting Institution

Yok

Project Number

Yok

Thanks

Dr. Ertan Sever (Teknik Desteğinden dolayı)

Pharmacognosic Studies on Lavandula angustifolia Miller Essential Oil

Abstract

Lavandula species are plants that are used in treatment, perfumery, food, cosmetics, and pharmaceutical industries due to the compounds they contain. Lavandula angustifola Miller plant, which is the subject of the research, is used to treat various diseases in folk medicine. The plant is widely cultivated in our country. Lavandula species are especially important because of the essential oil they contain, as well as their various active ingredients. Lavandula angustifolia Miller is the species that has more and the most valuable essential oil than other species. In addition, the essential oils of Lavandula latifolia and Lavandula hybrida are also of commercial importance. The plant has been collected from Keçiborlu district of Isparta province in this study. The plant's flowering tops have been distilled, and essential oil has been obtained at the rate of 3.39% (v/w) on the dry weight. This essential oil obtained from Lavandula angustifolia has been analyzed by using GC-MS, and 34 compounds have been detected. As the main components in essential oil; linalool (47.66%), 1.8-cineol (9.10%), linalyl acetate (7.65%) and camphor (6.46%) have been detected. According to the results of this research, the essential oil obtained from Lavandula angustifola is an essential oil that can be evaluated in the food, cosmetic, soap, and pharmaceutical industries and the fields of phytotherapy and aromatherapy due to its composition which is similar to lavandin essence.

Keywords

Lavandula angustifolia, Lavender oil, Linalool, Linalyl acetate

Project Number

Yok

References

• Banthorpe, D. V., Branch, S. A., Njar, V. C. O., Osborne, M. G. ve Watson, D. G. (1986). Ability of plant callus-cultures to synthesize and accumulate lower terpenoids. Phytochemistry, 25(3), 629-636.
• Batı Akdeniz Kalkınma Ajansı (BATA 2020). Lavanta Tarımı ve Endüstrisi Fizibilite Raporu T.C. Sanayi ve Teknoloji Bakanlığı Batı Akdeniz Kalkınma Ajansı.
• Bauer, K., Garbe, D. ve Surburg, H. (1997). Common fragrance and flavor materials. Weinheim, Germany: Wiley-VCH.
• Baytop, T. (1999). Türkiyede bitkiler ile tedavi (geçmişte ve bugün). İstanbul: Nobel Tıp Kitabevleri.
• Boelens, M. H. (1995). Chemical and sensory evaluation of Lavandula oils. Perfumer and Flavorist, 20, 23-51.
• Bogdan, M. A., Bungau, S., Tit, D. M., Zaha, D. C., Nechifor, A. C., Behl, T., ...Copolovici, D. M. (2021). Chemical profile, antioxidant capacity, and antimicrobial activity of essential oils extracted from three different varieties (Moldoveanca 4, Vis Magic 10, and Alba 7) of Lavandula angustifolia. Molecules, 26(14), 1-20.
• Buchbauer, G., Jirovetz, L., Jager, W., Plank, C. ve Dietrich, H. (1993). Fragrance Compounds and Essential Oils with Sedative Effects Upon Inhalation. Journal of Pharmaceutical Sciences, 82(6), 660-664.
• Caprari, C., Fantasma, F., Divino, F., Bucci, A., Iorizzi, M., Naclerio, G., ...Saviano, G. (2021). Chemical profile, in vitro biological activity and comparison of essential oils from fresh and dried flowers of Lavandula angustifolia L. Molecules, 26(17), 1-20.
• Caputo, L., Souza, L. F., Alloisio, S., Cornara, L. ve De Feo, V. (2016). Coriandrum sativum and Lavandula angustifolia essential oils: chemical composition and activity on central nervous system. Int J Mol Sci, 17(12), 2-12.
• Ciocarlan, A., Lupascu, L., Aricu, A., Dragalin, I., Popescu, V., Geana, E. I., ...Zinicovscaia, I. (2021). Chemical composition and assessment of antimicrobial activity of lavender essential oil and some by-products. Plants (Basel), 10(9), 2-14. D'Auria, F. D., Tecca, M., Strippoli, V., Salvatore, G., Battinelli, L. ve Mazzanti, G. (2005). Antifungal activity of Lavandula angustifolia essential oil against Candida albicans yeast and mycelial form. Med Mycol, 43(5), 391-396.
• Davis, P. H. (1978). Flora of Turkey and the East Aegean Islands. (Vol. 7). Edinburgh: Edinburgh University Press.
• De Martino, L., De Feo, V. ve Nazzaro, F. (2009). Chemical composition and in Vitro antimicrobial and mutagenic activities of seven lamiaceae essential oils. Molecules, 14(10), 4213-4230.
• de Pascual Teresa, J., Ovejero, J., Anaya, J., Caballero, E., Hernandez, J. M. ve Caballero, M. C. (1989). Chemical composition of the spanish spike oil. Planta Med, 55(4), 398.
• Fintelmann, V., Menßen, H. ve Sieger, C. (1993). Phytotherapie Manual. Stuttgart: Hippokrates Verlag.
• Gamez, M. J., Jimenez, J., Navarro, C. ve Zarzuelo, A. (1990). Study of the essential oil of Lavandula dentata L. Pharmazie, 45(1), 69-70. Erişim adresi: https://www.ncbi.nlm.nih.gov/pubmed/2333318
• Garcia-Vallejo, M., Garcia-Vallejo, I. ve Velasco-Negueruela, A. (1990). Essential oils of genus Lavandula L. in Spain. Paper presented at the Proceedings of the 11th International Congress of essential oils, fragrances and flavours. New Delhi, India, 12-16 November, 1989(4), 15-26.
• Guillen, M. D., Cabo, N. ve Burillo, J. (1996). Characterisation of the essential oils of some cultivated aromatic plants of industrial interest. Journal of the Science of Food and Agriculture, 70(3), 359-363.
• Jain, R., Ahmad, M. ve Limaye, D. (1993). Antiinflammatory principles from natural sources. Hamdard-Medicus, 36(3), 16.
• Khoury, M., Stien, D., Eparvier, V., Ouaini, N. ve El Beyrouthy, M. (2016). Report on the medicinal use of eleven lamiaceae species in lebanon and rationalization of their antimicrobial potential by examination of the chemical composition and antimicrobial activity of their essential oils. Evid Based Complement Alternat Med, 1-17.
• Kovatcheva, E., Pavlov, A., Koleva, I., Ilieva, M. ve Mihneva, M. (1996). Rosmarinic acid from Lavandula vera MM cell culture. Phytochemistry, 43(6), 1243-1244.
• Lammerink, J., Wallace, A. R. ve Porter, N. G. (1989). Effects of harvest time and postharvest drying on oil from Lavandin (Lavandula X Intermedia). New Zealand Journal of Crop and Horticultural Science, 17(4), 315-326.
• Lesage-Meessen, L., Bou, M., Ginies, C., Chevret, D., Navarro, D., Drula, E., …Lomascolo, A. (2018). Lavender- and lavandin-distilled straws: an untapped feedstock with great potential for the production of high-added value compounds and fungal enzymes. Biotechnol Biofuels, 11, 217.
• Mansour, F., Ravid, U. ve Putievsky, E. (1986). Studies of the Effects of Essential Oils Isolated from 14 Species of Labiatae on the Carmine Spider-Mite, Tetranychus-Cinnabarinus. Phytoparasitica, 14(2), 137-142.
• Miastkowska, M., Kantyka, T., Bielecka, E., Kalucka, U., Kaminska, M., Kucharska, M., ...Cudzik, K. (2021). Enhanced biological activity of a novel preparation of Lavandula angustifolia essential oil. Molecules, 26(9), 2-21.
• Mumcuoglu, K. Y., Galun, R., Bach, U., Miller, J. ve Magdassi, S. (1996). Repellency of essential oils and their components to the human body louse, Pediculus humanus humanus. Entomologia Experimentalis et Applicata, 78(3), 309-314.
• Perrucci, S., Macchioni, G., Cioni, P., Flamini, G., Morelli, I. ve Taccini, F. (1996). The activity of volatile compounds from Lavandula angustifolia against Psoroptes cuniculi. Phytotherapy research, 10(1), 5-8.
• Perrucci, S., Mancianti, F., Cioni, P. L., Flamini, G., Morelli, I. ve Macchioni, G. (1994). In-Vitro Antifungal Activity of Essential Oils against Some Isolates of Microsporum-Canis and Microsporum-Gypseum. Planta medica, 60(2), 184-187.
• Piccaglia, R. ve Marotti, M. (1993). Characterization of several aromatic plants grown in northern Italy. Flavour and fragrance journal, 8(2), 115-122.
• Polunin, O. (1969). Flowers of Europe. A field guide.
• Ravid, U., Putievsky, E. ve Katzir, I. (1996). Stereochemical analysis of Borneol in essential oils using permethylated β‐cyclodextrin as a chiral stationary phase. Flavour and fragrance journal, 11(3), 191-195.
• Reverchon, E., Dellaporte, G. ve Senatore, F. (1995). Supercritical Co2 extraction and fractionation of lavender essential oil and waxes. Journal of Agricultural and Food Chemistry, 43(6), 1654-1658.
• Scheffer, J. (1996). Various methods for the isolation of essential oils. Phytotherapy Research (United Kingdom).
• Shaaya, E., Kostjukovski, M., Eilberg, J. ve Sukprakarn, C. (1997). Plant oils as fumigants and contact insecticides for the control of stored-product insects. Journal of Stored Products Research, 33(1), 7-15.
• Shaaya, E., Ravid, U., Paster, N., Juven, B., Zisman, U. ve Pissarev, V. (1991). Fumigant toxicity of essential oils against four major stored-product insects. J Chem Ecol, 17(3), 499-504.
• Simandi, B., Kery, A., Lemberkovics, E., Oszagyan, M. ve Hethelyi, E. (1993). Supercritical fluid extraction of essential oils from Mentha piperita and Lavandula intermedia. Planta Medica, 59(S1), A626-A626.
• Tanker, M. ve Tanker, N. (1990). Farmakognozi Cilt 2, Ankara Üniv. Eczacılık Fak. Yayınları Ankara, 65, 148-149.
• Tanker, N. ve Şarer, E. (1975). L. cariensis Boiss. Bitkisinin uçucu yağı üzerinde farmakognozik araştırmalar. Ankara Ecz. Fak. Mec., 5, 19-39. Weiss, R. F. (1988). Herbal Medicine. AB Arcanum, Gothenburg, Sweden. Beaconsfield Publishers Ltd, Beaconsfield, England, 69, 203-205.
• Yamada, K., Mimaki, Y. ve Sashida, Y. (1994). Anticonvulsive effects of inhaling lavender oil vapour. Biol Pharm Bull, 17(2), 359-360.
• Zeybek, N. ve Zeybek, U. (1994). Farmasötik botanik. Ege Üniversitesi, Eczacılık Fakültesi Yayınları(2).
• Zheljazkov, V. D. ve Nielsen, N. E. (1996). Studies on the effect of heavy Metals (Cd, Pb, Cu, Mn, Zn and Fe) upon the Growth, Productivity and Quality of Lavender (Lavandula angustifoliaMill.) Production. Journal of essential oil research, 8(3), 259-274.