Year 2021, Volume 11 , Issue 2, Pages 1302 - 1310 2021-06-01

Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi
Determination of Biological Activities of Axially Disubstituted Silicon Phthalocyanines

Ayça AKTAŞ KARAÇELİK [1] , Derya EFE [2] , Volkan ÇAKIR [3] , Zekeriya BIYIKLIOĞLU [4]


Bu çalışmada daha önce sentezlenen eksenel ([3- (dimetilamino) fenoksi] propanooksi) ve ([3- (dietilamino) fenoksi] propanooksi) ikameli silisyum ftalosiyaninlerin (DM-C3-Si ve DE-C3-Si) biyolojik aktivitelerinin [sığır karbonik anhidraz (bCA) inhibisyonu, antioksidan ve antibakteriyel] değerlendirilmesi amaçlandı. CA inhibisyon aktivitesi, esteraz aktivitesi ile belirlendi. Antioksidan aktivite, iki yaygın yöntem olan 2,2-difenil-1-pikrilhidrazil (DPPH•) radikal temizleme ve demir iyon (III) indirgeme / antioksidan güç (FRAP) metotları ile belirlendi. Antibakteriyel aktivite, üç Gram-negatif ve üç Gram-pozitif bakteriye karşı disk difüzyon yöntemi ile belirlendi. Sonuçlara göre, DE-C3-Si silisyum ftalosiyanin, standart CA inhibitörü sülfanilamide kıyasla 2333 nM IC50 değeriyle yaklaşık iki kat daha yüksek CA inhibitör aktivitesi gösterdi. Antioksidan sonuçlarına göre, silisyum ftalosiyaninler standart C vitamininden daha yüksek antioksidan aktivite gösterdi (DPPH• radikal temizleme SC50 değerleri: DM-C3-Si: 0.0199 mg mL-1 ve DE-C3-Si: 0.0232 mg mL-1, FRAP TEAC değerleri: DM-C3-Si: 232 μM ve DE-C3-Si: 73 μM). Bu bileşiklerin antibakteriyel aktivitesinin Gram-negatif ve Gram-pozitif bakterilere karşı çok az olduğu gözlendi. Sonuç olarak, silisyum ftalosiyaninler, biyolojik aktiviteleri nedeniyle yeni CA inhibitörlerinin keşfinde ve gıdalarda büyük kullanım potansiyeline sahiptir.
In this study, previously synthesized axially ([3-(dimethylamino)phenoxy]propanoxy) and ([3-(diethylamino)phenoxy]propanoxy) substituted silicon phthalocyanines (DM-C3-Si and DE-C3-Si) were aimed to evalute biological activities [bovine carbonic anhydrase (bCA) inhibition, antioxidant, and antibacterial]. CA inhibition activity was determined by esterase activity. The antioxidant activity was determined by two common methods, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging and ferric ion (III) reducing / antioxidant power (FRAP) assay. The antibacterial activity was determined by the disk diffusion method against three Gram-negative and three Gram-positive bacteria. According to the results, DE-C3-Si silicon phthalocyanin showed approximately twice as high CA inhibitory activity with IC50 value of 2333 nM compared with the standard CA inhibitor sulfanilamide. According to the antioxidant studies, the silicon phthalocyanines showed higher antioxidant activity than the standard vitamin C (SC50 values of DPPH• scavenging activity: 0.0199 mg mL-1 for DM-C3-Si and 0.0232 mg mL-1 for DE-C3-Si, TEAC values of FRAP: 232 μM for DM-C3-Si and 73 μM for DE-C3-Si). It was observed that antibacterial activity of these compounds were exellent slight against Gram-negative and Gram-positive bacteria. As a result, silicon phthalocyanines have great potential of use in the discovery of new CA inhibitors and in food due to their biological activities.
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Primary Language tr
Subjects Engineering, Chemical
Published Date Haziran-2021
Journal Section Kimya / Chemistry, Kimya Mühendisliği / Chemical Engineering
Authors

Orcid: 0000-0001-5381-2924
Author: Ayça AKTAŞ KARAÇELİK (Primary Author)
Institution: Giresun University
Country: Turkey


Orcid: 0000-0003-3554-1790
Author: Derya EFE
Institution: Giresun University
Country: Turkey


Orcid: 0000-0002-5817-0817
Author: Volkan ÇAKIR
Institution: Giresun University
Country: Turkey


Orcid: 0000-0001-5138-214X
Author: Zekeriya BIYIKLIOĞLU
Institution: Karadeniz Technical University
Country: Turkey


Thanks Bu çalışmanın test ve analizlerinin Espiye Meslek Yüksekokulundaki araştırma laboratuarlarında yapılmasına imkan sağlayan Giresun Üniversitesi’ ne teşekkür ederiz.
Dates

Application Date : October 2, 2020
Acceptance Date : January 12, 2021
Publication Date : June 1, 2021

Bibtex @research article { jist804539, journal = {Journal of the Institute of Science and Technology}, issn = {2146-0574}, eissn = {2536-4618}, address = {}, publisher = {Igdir University}, year = {2021}, volume = {11}, pages = {1302 - 1310}, doi = {10.21597/jist.804539}, title = {Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi}, key = {cite}, author = {Aktaş Karaçelik, Ayça and Efe, Derya and Çakır, Volkan and Bıyıklıoğlu, Zekeriya} }
APA Aktaş Karaçelik, A , Efe, D , Çakır, V , Bıyıklıoğlu, Z . (2021). Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi . Journal of the Institute of Science and Technology , 11 (2) , 1302-1310 . DOI: 10.21597/jist.804539
MLA Aktaş Karaçelik, A , Efe, D , Çakır, V , Bıyıklıoğlu, Z . "Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi" . Journal of the Institute of Science and Technology 11 (2021 ): 1302-1310 <https://dergipark.org.tr/en/pub/jist/issue/61423/804539>
Chicago Aktaş Karaçelik, A , Efe, D , Çakır, V , Bıyıklıoğlu, Z . "Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi". Journal of the Institute of Science and Technology 11 (2021 ): 1302-1310
RIS TY - JOUR T1 - Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi AU - Ayça Aktaş Karaçelik , Derya Efe , Volkan Çakır , Zekeriya Bıyıklıoğlu Y1 - 2021 PY - 2021 N1 - doi: 10.21597/jist.804539 DO - 10.21597/jist.804539 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 1302 EP - 1310 VL - 11 IS - 2 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.804539 UR - https://doi.org/10.21597/jist.804539 Y2 - 2021 ER -
EndNote %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi %A Ayça Aktaş Karaçelik , Derya Efe , Volkan Çakır , Zekeriya Bıyıklıoğlu %T Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi %D 2021 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 11 %N 2 %R doi: 10.21597/jist.804539 %U 10.21597/jist.804539
ISNAD Aktaş Karaçelik, Ayça , Efe, Derya , Çakır, Volkan , Bıyıklıoğlu, Zekeriya . "Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi". Journal of the Institute of Science and Technology 11 / 2 (June 2021): 1302-1310 . https://doi.org/10.21597/jist.804539
AMA Aktaş Karaçelik A , Efe D , Çakır V , Bıyıklıoğlu Z . Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi. Iğdır Üniv. Fen Bil Enst. Der.. 2021; 11(2): 1302-1310.
Vancouver Aktaş Karaçelik A , Efe D , Çakır V , Bıyıklıoğlu Z . Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi. Journal of the Institute of Science and Technology. 2021; 11(2): 1302-1310.
IEEE A. Aktaş Karaçelik , D. Efe , V. Çakır and Z. Bıyıklıoğlu , "Aksiyal Disübstitüe Silisyum Ftalosiyaninlerin Biyolojik Aktivitelerinin Belirlenmesi", Journal of the Institute of Science and Technology, vol. 11, no. 2, pp. 1302-1310, Jun. 2021, doi:10.21597/jist.804539