Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi

Year 2021, Volume: 11 Issue: 2, 1374 - 1384, 01.06.2021

Yusuf Akbaba

https://doi.org/10.21597/jist.826733

Abstract

Bu çalışmada, bir dizi potansiyel biyolojik aktif asimetrik üre türevi sentezlenmiştir. Buna göre (R)-(+)-1-feniletilamin (7) 1,1’-karbonildiimidazol ile su içerisinde reaksiyona sokulmuş ve imidazolid ara ürünleri oluşturulmuştur. Daha sonra üzerine fenetilamin (8a) ve sübstitüe fenetilamin türevleri (8b-e) verildi. Sonuç olarak, potansiyel biyolojik aktif yeni asimetrik üreler (R)-1-fenetil-3- (1-feniletil) üre (9a) ve sübstitüe türevleri (9b-e), % 60 - % 71 arasındaki verimlerle elde edildi.

Keywords

Asimetrik üre, 1-feniletilamin, fenetilamin, 1,1’-karbonildiimidazol

Thanks

Bu çalışma Erzurum Teknik Üniversitesi Yüksek Teknoloji Araştırma ve Uygulama Merkezi Organik Kimya Araştırma Laboratuvarında Yapılmıştır. Ayrıca NMR spektrumları Atatürk Üniversitesi Fen Fakültesi Kimya Bölümünde alınmıştır. Her iki kurumada teşekkür ederim

Synthesis of Potentially Biologically Active Some Asymmetric Phenylethyl Urea Derivatives

Abstract

In this study, a number of potentially biologically active asymmetric urea derivatives were synthesized. Accordingly, (R)-(+)-1-phenylethylamine (7) was reacted with 1,1'-carbonyldiimidazole in water and imidazolide intermediates were formed. Then phenethylamine (8a) and substituted phenethylamine derivatives (8b-e) were given. As a result, potentially biologically active novel asymmetric ureas (R)-1-phenethyl-3-(1-phenylethyl) urea (9a) and substituted derivatives (9b-e) were obtained in yields between 60% - 71%.

Keywords

Asymmetric urea, 1-phenylethylamine, phenethylamine, 1,1’-carbonyldiimidazole

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