Year 2021, Volume 11 , Issue 2, Pages 1374 - 1384 2021-06-01

Synthesis of Potentially Biologically Active Some Asymmetric Phenylethyl Urea Derivatives
Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi

Yusuf AKBABA [1]


In this study, a number of potentially biologically active asymmetric urea derivatives were synthesized. Accordingly, (R)-(+)-1-phenylethylamine (7) was reacted with 1,1'-carbonyldiimidazole in water and imidazolide intermediates were formed. Then phenethylamine (8a) and substituted phenethylamine derivatives (8b-e) were given. As a result, potentially biologically active novel asymmetric ureas (R)-1-phenethyl-3-(1-phenylethyl) urea (9a) and substituted derivatives (9b-e) were obtained in yields between 60% - 71%.
Bu çalışmada, bir dizi potansiyel biyolojik aktif asimetrik üre türevi sentezlenmiştir. Buna göre (R)-(+)-1-feniletilamin (7) 1,1’-karbonildiimidazol ile su içerisinde reaksiyona sokulmuş ve imidazolid ara ürünleri oluşturulmuştur. Daha sonra üzerine fenetilamin (8a) ve sübstitüe fenetilamin türevleri (8b-e) verildi. Sonuç olarak, potansiyel biyolojik aktif yeni asimetrik üreler (R)-1-fenetil-3- (1-feniletil) üre (9a) ve sübstitüe türevleri (9b-e), % 60 - % 71 arasındaki verimlerle elde edildi.
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Primary Language tr
Subjects Engineering, Chemical
Published Date Haziran-2021
Journal Section Kimya / Chemistry, Kimya Mühendisliği / Chemical Engineering
Authors

Orcid: 0000-0002-7770-0473
Author: Yusuf AKBABA (Primary Author)
Institution: ERZURUM TEKNİK ÜNİVERSİTESİ
Country: Turkey


Thanks Bu çalışma Erzurum Teknik Üniversitesi Yüksek Teknoloji Araştırma ve Uygulama Merkezi Organik Kimya Araştırma Laboratuvarında Yapılmıştır. Ayrıca NMR spektrumları Atatürk Üniversitesi Fen Fakültesi Kimya Bölümünde alınmıştır. Her iki kurumada teşekkür ederim
Dates

Application Date : November 16, 2020
Acceptance Date : February 2, 2021
Publication Date : June 1, 2021

Bibtex @research article { jist826733, journal = {Journal of the Institute of Science and Technology}, issn = {2146-0574}, eissn = {2536-4618}, address = {}, publisher = {Igdir University}, year = {2021}, volume = {11}, pages = {1374 - 1384}, doi = {10.21597/jist.826733}, title = {Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi}, key = {cite}, author = {Akbaba, Yusuf} }
APA Akbaba, Y . (2021). Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi . Journal of the Institute of Science and Technology , 11 (2) , 1374-1384 . DOI: 10.21597/jist.826733
MLA Akbaba, Y . "Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi" . Journal of the Institute of Science and Technology 11 (2021 ): 1374-1384 <https://dergipark.org.tr/en/pub/jist/issue/61423/826733>
Chicago Akbaba, Y . "Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi". Journal of the Institute of Science and Technology 11 (2021 ): 1374-1384
RIS TY - JOUR T1 - Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi AU - Yusuf Akbaba Y1 - 2021 PY - 2021 N1 - doi: 10.21597/jist.826733 DO - 10.21597/jist.826733 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 1374 EP - 1384 VL - 11 IS - 2 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.826733 UR - https://doi.org/10.21597/jist.826733 Y2 - 2021 ER -
EndNote %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi %A Yusuf Akbaba %T Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi %D 2021 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 11 %N 2 %R doi: 10.21597/jist.826733 %U 10.21597/jist.826733
ISNAD Akbaba, Yusuf . "Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi". Journal of the Institute of Science and Technology 11 / 2 (June 2021): 1374-1384 . https://doi.org/10.21597/jist.826733
AMA Akbaba Y . Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi. Iğdır Üniv. Fen Bil Enst. Der.. 2021; 11(2): 1374-1384.
Vancouver Akbaba Y . Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi. Journal of the Institute of Science and Technology. 2021; 11(2): 1374-1384.
IEEE Y. Akbaba , "Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi", Journal of the Institute of Science and Technology, vol. 11, no. 2, pp. 1374-1384, Jun. 2021, doi:10.21597/jist.826733