Year 2021, Volume 11 , Issue 2, Pages 1341 - 1353 2021-06-01

Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu
Effective Synthesis and Characterization of Bis(Sulfonamide) Containing Chalcone

Elif AKIN KAZANCIOĞLU [1]


Bu çalışmada, sülfonamid içeren yeni kalkon türevleri hızlı ve etkili bir şekilde sentezlendi. Kalkon iskelet yapısının sentezi, baz katalize Claisen-Schmidt kondenzasyon reaksiyon yöntemi kullanılarak yapıldı. 4-metoksi asetofenon, 4-nitrobenzaldehit ve NaOH’in reaksiyonu sonucu 3 nolu kalkon %80 verimle sentezlendi. Elde edilen 1-(4-metoksifenil)-3-(4-nitrofenil)prop-2-en-1-on (3) bileşiğindeki, nitro fonksiyonel grubunun SnCl2.2H2O ile indirgenmesiyle hedef bileşik 3-(4-aminofenil)-1-(4-metoksifenil)prop-2-en-1-on (4) %98 verimle elde edildi. Aminin (4), 3-(triflorometil)benzensülfonil klorür, 4-florobenzensülfonil klorür, 4-metoksibenzensülfonil klorür, naftalen-1-sülfonil klorür, pridin-3-sülfonil klorür ve metansülfonil klorür ile reaksiyonu sonucu Alzheimer hastalığı başta olmak üzere birçok farklı terapötik uygulamada kullanılabilme potansiyeline sahip olan moleküllerin sentezi başarılı bir şekilde gerçekleştirildi.
In this study, new chalcone derivatives containing sulfonamide were synthesized rapidly and efficiently. The synthesis of the chalcone skeletal structure was performed using the base-catalyzed Claisen-Schmidt condensation reaction method. Chalcone 3 was synthesized with 80% yield as a result of the reaction of 4-methoxy acetophenone, 4-nitrobenzaldehyde and NaOH. Reduction of the nitro functional group in compound 1-(4-methoxyphenyl)-3-(4-nitrophenyl)prop-2-en-1-one (3) with SnCl2.2H2O obtained the target compound 3-(4-aminophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (4) in 98% yield. The synthesis of target molecules that has the potential to be used in many different therapeutic applications, including Alzheimer's disease, has been successfully achieved as a result of the reaction of amine (4) with 3-(trifluoromethyl)benzenesulfonyl chloride, 4-fluorobenzenesulfonyl chloride, 4-methoxybenzenesulfonyl chloride, naphthalene-1-sulfonyl chloride, pyridine-3-sulfonyl chloride and methanesulfonyl chloride.
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Primary Language tr
Subjects Science
Published Date Haziran-2021
Journal Section Kimya / Chemistry, Kimya Mühendisliği / Chemical Engineering
Authors

Orcid: 0000-0001-7486-685X
Author: Elif AKIN KAZANCIOĞLU (Primary Author)
Institution: KİLİS 7 ARALIK ÜNİVERSİTESİ
Country: Turkey


Supporting Institution Kilis 7 Aralık Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi
Project Number 12411
Thanks Bu çalışma, Kilis 7 Aralık Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından “12411” kodlu proje ile desteklenmiştir.
Dates

Application Date : January 3, 2021
Acceptance Date : January 27, 2021
Publication Date : June 1, 2021

Bibtex @research article { jist852907, journal = {Journal of the Institute of Science and Technology}, issn = {2146-0574}, eissn = {2536-4618}, address = {}, publisher = {Igdir University}, year = {2021}, volume = {11}, pages = {1341 - 1353}, doi = {10.21597/jist.852907}, title = {Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu}, key = {cite}, author = {Akın Kazancıoğlu, Elif} }
APA Akın Kazancıoğlu, E . (2021). Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu . Journal of the Institute of Science and Technology , 11 (2) , 1341-1353 . DOI: 10.21597/jist.852907
MLA Akın Kazancıoğlu, E . "Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu" . Journal of the Institute of Science and Technology 11 (2021 ): 1341-1353 <https://dergipark.org.tr/en/pub/jist/issue/61423/852907>
Chicago Akın Kazancıoğlu, E . "Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu". Journal of the Institute of Science and Technology 11 (2021 ): 1341-1353
RIS TY - JOUR T1 - Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu AU - Elif Akın Kazancıoğlu Y1 - 2021 PY - 2021 N1 - doi: 10.21597/jist.852907 DO - 10.21597/jist.852907 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 1341 EP - 1353 VL - 11 IS - 2 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.852907 UR - https://doi.org/10.21597/jist.852907 Y2 - 2021 ER -
EndNote %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu %A Elif Akın Kazancıoğlu %T Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu %D 2021 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 11 %N 2 %R doi: 10.21597/jist.852907 %U 10.21597/jist.852907
ISNAD Akın Kazancıoğlu, Elif . "Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu". Journal of the Institute of Science and Technology 11 / 2 (June 2021): 1341-1353 . https://doi.org/10.21597/jist.852907
AMA Akın Kazancıoğlu E . Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu. Iğdır Üniv. Fen Bil Enst. Der.. 2021; 11(2): 1341-1353.
Vancouver Akın Kazancıoğlu E . Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu. Journal of the Institute of Science and Technology. 2021; 11(2): 1341-1353.
IEEE E. Akın Kazancıoğlu , "Bis(Sülfonamid) İhtiva Eden Kalkon Türevlerinin Etkin Bir Şekilde Sentezi ve Karakterizasyonu", Journal of the Institute of Science and Technology, vol. 11, no. 2, pp. 1341-1353, Jun. 2021, doi:10.21597/jist.852907