AbstractThe Effects of Novel-to-Novel Stimulus Intervals on N2b-P3a Complex In Auditory Three Stimulus Paradigm Objective: The three stimulus (novelty) paradigm in cognitive electrophysiology is designed to investigate the effects of novel stimuli on brain electrical activity. The typical event related potential component is a N2b-P3a complex occurring in response to non-target novels during the novelty paradigm. The aim of present study is to investigate the effects of novel-to-novel interval changes on the auditory N2b-P3a complex. Method: Fifteen healthy male volunteers participated in the study. Event related potentials were recorded with 30 electrodes using an auditory novelty paradigm. According to durations of novel-to-novel intervals, recorded event related potential sweeps were divided into two groups as short and long. The amplitude and latency values of N2b and P3a potentials in the averaged responses to novel stimuli were measured and then analyzed by repeated measures analyses of variance (ANOVA) for both interval groups. Results: Statistical analyses indicate that the P3a and peak-to-peak P3a amplitudes were bigger (p<0.01 and p<0.001, respectively); and the P3a latencies were shorter (p<0.05) in the event related potential trials with longer novel-to-novel intervals at all electrodes. However, the amplitudes and latencies of N2b responses were not different between the two interval groups (p>0.05). Conclusion: The results suggest that the novel-to-novel intervals modulate amplitudes and latencies of the auditory P3a responses. Therefore, the analysis of novelty P3a responses in conjunction with novel-to-novel intervals can introduce further specificity to the cognitive event related potential findings.
Türkçe Özet:Amaç: Bilişsel elektrofizyolojideki üçlü uyaran (yenilik) paradigması, yeni uyaranların beynin elektriksel aktivitesi üzerine olan etkilerini araştırmak için tasarlanmıştır. Yenilik paradigması sırasında elde edilen tipik olaya ilişkin potansiyel bileşeni hedef olmayan yeni uyaranlara karşı ortaya çıkan bir N2b-P3a kompleksidir. Bu çalışmada, yeni-yeni uyaran intervallerindeki değişkenliklerin işitsel N2b-P3a kompleksi üzerine olan etkilerinin araştırılması amaçlandı. Yöntem: Çalışmaya 15 sağlıklı erkek gönüllü katıldı. Olaya ilişkin potansiyeller, işitsel yenilik paradigması kullanılarak, 30 elektrot bölgesinden kaydedildi. Kaydedilen olaya ilişkin potansiyel dilimleri, yeni-yeni uyaran intervallerinin sürelerine göre kısa ve uzun olarak iki gruba ayrıldı. Bu iki interval grubunda yeni uyaranlara karşı elde edilen ortalama yanıtlardaki N2b ve P3a potansiyellerinin genlik ve latans değerleri ölçüldü ve ardından tekrarlanan ölçümlü varyans analizi testi ile analiz edildi. Bulgular: İstatistiksel analizler; tüm elektrot bölgelerinde, daha uzun yeni-yeni uyaran intervalleri içeren olaya ilişkin potansiyel dilimlerindeki P3a ve tepeden-tepeye P3a genliklerinin daha büyük (sırasıyla p<0.01 ve p<0.001), P3a latanslarının ise daha kısa olduğunu gösterdi (p<0.05). Buna karşılık, N2b yanıtlarının genlik ve latansları bu iki interval grubu arasında farklı değildi (p>0.05). Sonuç: Sonuçlarımız yeni-yeni uyaran intervallerinin işitsel P3a yanıtlarının genlik ve latanslarını modüle ettiğini göstermektedir. Bu bağlamda; yenilik P3a analizlerinin yeni-yeni uyaran intervalleri göz önüne alınarak yapılması, bilişsel olaya ilişkin potansiyel bulgularına daha fazla özgüllük kazandırabilecektir.
Primary Language | Turkish |
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Journal Section | Articles |
Authors | |
Publication Date | September 1, 2009 |
Submission Date | June 13, 2014 |
Published in Issue | Year 2009 Volume: 2 Issue: 3 |
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