Recently, drug release applications through the skin have become very popular. One of the most remarkable of these drug release applications is transdermal drug release systems, which are drug release methods that allow the active substance to pass into the systemic circulation through the skin or artificial membranes. In this study, the optimization conditions required for the release and permeation tests of a gel drug containing the active substance thiocolchicoside were comparatively investigated using synthetic membranes without human or animal skin. For this purpose, the permeability of the gel drug in gel form and the active ingredient thiocolchicoside was carried out using Franz Diffusion Cell. As a result of the investigations, it was observed that the best synthetic membrane for the permeability of thiocolchicoside in the Franz Diffusion Cell was the Supor membrane. In addition, the method's relative standard deviation values, detection, and quantification limits were determined, and permeation studies were carried out. In this study, the correlation coefficient was found to be 0.9992, and the limits of detection and quantification were 0.026 and 0.078 µg/L. In this way, the sensitivity and reliability of the validation study were determined.
Thiocolchicoside Franz diffusion cell Synthetic membranes Transdermal drug delivery system HPLC
Düzce University
2023.05.03.1406
The author wants to thank Düzce University.
2023.05.03.1406
Primary Language | English |
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Subjects | Analytical Spectrometry |
Journal Section | Research Articles |
Authors | |
Project Number | 2023.05.03.1406 |
Early Pub Date | August 1, 2024 |
Publication Date | |
Submission Date | March 21, 2024 |
Acceptance Date | May 22, 2024 |
Published in Issue | Year 2024 Volume: 28 Issue: 4 |
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