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Ağız kuruluğunun etiyolojisi ve tedavisinde günümüzdeki yaklaşım

Year 2005, Volume: 12 Issue: 4, 58 - 67, 16.04.2009

Abstract

SüleymanDemirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2005 Aralık; 12(4)








Ağız kuruluğunun etiyolojisi ve tedavisinde günümüzdeki yaklaşım



A. Diljin Keçeci, Feyza Özdemir



Özet

Ağız kuruluğu, hastaya ait subjektif rahatsızlık yaratmasının yanı sıra tükrüğün fizyolojik yıkama etkisinin ortadan kalkması ve ağız florasında ortaya çıkan değişikliklerle diş çürüklerinde anlamlı düzeyde artışa neden olur. Bu nedenle ağız kuruluğuna neden olan hastalıklar ve ilaç kullanımının veya radyoterapinin etkilerinin bilinmesi bu terapiyi yapan hekim ve dişhekiminin önemli bir sorumluluğudur. Bunun yanında hastaların oral hijyen şartlarının iyleştirilmesi ve ağız kuruluğunu önleyici tedaviler konusunda bilgilendirilmeleri gerekir.



Anahtar kelimeler: ağız kuruluğu, etiyoloji, kemoterapi, radyoterapi, pilokarpin, tükrük destekleyiciler



Abstract



Contemporary approach to the etiology and therapy of xerostomia

It is well known that xerostomia causes subjective discomfort of the patient and also alterations of oral microflora due to loss of washing effect of saliva resulting in a significant caries incidence. Therefore, the knowledge on the effects of diseases, medications or radiotherapy which cause xerostomia is an important responsibility of both, for a physician or dentist. Besides, patients should be informed about the change of oral hygen conditions and preventive measures against xerostomia.



Key words: Xerostomia,etyology, chemotherapy, radiotherapy, pilokarpin salivary substitutes

References

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Year 2005, Volume: 12 Issue: 4, 58 - 67, 16.04.2009

Abstract

References

  • Bergdahl M, Bergdahl J. Low unstimulated salivary flow and subjective oral dryness: association with medication, anxiety,depression and stress. J Dent Res 2000;79:1652-8.
  • Berne RM. Physiology. 4th ed. St Louis (MO): Mosby, 1998;619-21.
  • Carlson GW. The salivary glands. Embryology, anatomy, and surgical applications. Surg Clin North Am 2000;80:261-73.
  • Nagler RM. Salivary glands and the aging process: mechanistic aspects, health-status and medicinal- efficacy monitoring.Biogerontology. 2004;5:223-33.
  • Porter SR, Scully C. Adverse drug reactions in the mouth. Clin Dermatol 2000;18:525-32.
  • Pajukoski H, Meurman JH, Halonen P, Sulkava R. Prevalence of subjective dry mouth and burning mouth in hospitalized elderly patients and outpatients in relation to saliva, medication, and systemic diseases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • Trindade E, Menon D, Topfer LA, Coloma C. Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. CMAJ 1998;159:1245-52.
  • Hunter KD, Wilson WS. The effects of antidepressant drugs on salivary flow and content of sodium and potassium ions in human parotid saliva. Arch Oral Biol 1995;40:983-9.
  • Ravindran AV, Judge R, Hunter BN, Bray J, Morton NH. A double-blind, multicenter study in primary care comparing paroxetine and clomipramine in patients with depression and associated anxiety. Paroxetine Study Group. J Clin Psychiatry 1997;58:112-8.
  • Teare JP, Spedding C, Whitehead MW, Greenfield SM, Challacombe SJ, Thompson RP. Omeprazole and dry mouth. Scand J Gastroenterol 1995;30:216-8.
  • Bruera E, Belzile M, Neumann CM, Ford I, Harsanyi Z, Darke A. Twice-daily versus once-daily morphine sulphate controlled-release suppositories for the treatment of cancer pain.A randomized controlled trial. Support Care Cancer 1999;7: 280-3.
  • Hill JL, Zacny JP. Comparing the subjective, psychomotor, and physiological effects of intravenous hydromorphone and morphine in healthy volunteers. Psychopharmacology (Berl) 2000; 152:31-9.
  • Chilla R, Arglebe C. Pharmacotherapy of hypertension and its significance for the function of the salivary glands (author’s translation). MMW Munch Med Wochenschr 1975;117:1425-8.
  • Schoenberger JA, Croog SH, Sudilovsky A, Levine S, Baume RM. Self-reported side effects from antihypertensive drugs. A clinical trial. Quality of Life Research Group. Am J Hypertens 1990;3:123-32.
  • Croog SH, Elias MF, Colton T, Baume RM, Leiblum SR, Jenkins CD, et al. Effects of antihypertensive medications on quality of life in elderly hypertensive women. Am J Hypertens 1994;7:329-39.
  • Nederfors T. Xerostomia: prevalence and pharmacotherapy. With special reference to beta- adrenoceptor antagonists. Swed Dent J Suppl 1996;116:1-70.
  • Öktem F, Uzel Ö, Ada M, Toprak M, Cansýz H, .Gülen H, Tuksan K Nazofarinks Kanserli Hastalarda Radyoterapi Sonras›Kulak Burun Boðaz Morbiditesi. Türk Otolarengoloji Arþivi, 2001;39:121-26
  • Epstein JB, Stevenson-Moore P, Scully C. Management of xerostomia. J Can Dent Assoc 192;58:140-3.
  • Epstein JB, van der Meji EH, Lunn R, Steverson- Moore P. Effects of compliance with fluoride gel application on caries and caries risk in patients after radiation therapy for head and neck cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:268- 75
  • Porter SR, Scully C, Hegarty AM. An update of the etiology and management of xerostomia.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 J;97:28- 46.
  • Singh N, Scully C, Joyston-Bechal S. Oral complications of cancer therapies: prevention and management. Clin Oncol (R Coll Radiol) 1996;8:15- 24.
  • Pow EH, McMillan AS, Leung WK, Wong MC, Kwong DL. Salivary gland function and xerostomia in southern Chinese following radiotherapy for nasopharyngeal carcinoma. Clin Oral Investig 2003;7(4):230-4.
  • Davies AN, Broadley K, Beighton D. Xerostomia in patients with advanced cancer. J Pain Symptom Manage 2001;22:820-50.
  • Yücel E, Delibaþý E, Pediatrik kanser hastalarýnda kemoterapinin neden olduðu oral komplikasyonlar (Bir vaka nedeniyle) GÜ Diþhek Fak Derg 1986;3:161-8..
  • Ackerstaff AH, Tan IB, Rasch CR, Balm AJ, Keus RB, Schornagel JH, et al. Quality-of-life assessment after supradose selective intra-arterial cisplatin and concomitant radiation (RADPLAT) for inoperable stage IV head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2002;128:1185-90.
  • Nagler RM. Effects of radiotherapy and chemotherapeutic cytokines on a human salivary cell line. Anticancer Res 1998;18: 309-14.
  • Nagler RM, Sherman Y, Nagler A. Histopathological study of the human submandibular gland in graft versus host disease. J Clin Pathol 1999;52:395-7.
  • Levy S, Nagler A, Okon S, Marmary Y. Parotid salivary gland dysfunction in chronic graft-versus-host disease (cGVHD): a longitudinal study in a mouse model. Bone Marrow Transplant 2000;25:1073-8.
  • Demarosi F, Bez C, Sardella A, Lodi G, Carrassi A. Oral involvement in chronic graft-vs-host disease following allogenic bone marrow transplantation. Arch Dermatol 2002;138: 842-3.
  • Schubert MM, Sullivan KM, Morton TH, Izutsu KT, Peterson DE, Flournoy N, et al. Oral manifestations of chronic graft-vhost disease. Arch Intern Med 1984;144:1591-5.
  • Janin-Mercier A, Saurat JH, Bourges M, Sohier J, Jean LD, Gluckman E. The lichen planus like and sclerotic phases of the graft versus host disease in man: an ultrastructural study of six cases. Acta Derm Venereol 1981;61:187-93.
  • Nicolatou-Galitis O, Kitra V, Van Vliet-Constantinidou C, Peristeri J, Goussetis E, Petropoulos D, et al. The oral manifestations of chronic graft-versus-host disease (cGVHD) in paediatric allogeneic bone marrow transplant recipients. J Oral Pathol Med 2001;30:148- 53.
  • Fox RI, Stern M, Michelson P. Update in Sjögren syndrome. Curr Opin Rheumatol 2000;12:391-8.
  • Bowman SJ. Collaborative research into outcome measures in Sjögren’s syndrome. Update on disease assessment. Scand J Rheumatol Suppl 2002;116:23- 7.
  • Ohtsuka S, Yanadori A, Tabata H, Yamakage A, Yamazaki S. Sarcoidosis with giant parotomegaly. Cutis 2001;68:199-200.
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There are 101 citations in total.

Details

Primary Language English
Journal Section Derlemeler
Authors

A.diljin Keçeci

Feyza Özdemir This is me

Publication Date April 16, 2009
Submission Date April 16, 2009
Published in Issue Year 2005 Volume: 12 Issue: 4

Cite

Vancouver Keçeci A, Özdemir F. Ağız kuruluğunun etiyolojisi ve tedavisinde günümüzdeki yaklaşım. Med J SDU. 2009;12(4):58-67.

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