The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer

Volume: 37 Number: 3 September 1, 2011
  • Muharrem Bayrak
  • Ömer Fatih Ölmez
  • Ender Kurt
  • Erdem Çubukcu
  • Nilüfer Avcı
  • Sinem Çubukcu
  • Pınar Söker
  • Osman Manavoğlu
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The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer

Abstract

Pre-treatment serum levels of AFP, CEA and CA 19-9 were retrospectively investigated in 70 patients with locally advanced and metastatic gastric cancer. The positivity rates for these markers were 55.7%, 40% and 32.9%, respectively. Multiple logistic regression analysis for positive levels of tumor markers indicates that AFP positivity is significantly related to the presence of hepatic metastasis and resectability rates (p=0.041), CEA positivity is related to advance stage (p=0.011), tumor size (p=0.004), presence of hepatic metastasis (p=0.001), the frequency of serosal invasion (p=0.004) and resectability rates (p=0.011). Finally, CA 19-9 positivity is related to advance stage (p=0.006), tumor size (p=0.002), the frequency of serosal invasion (p=0.002), the frequency of peritoneal metastasis (p=0.005) and ascites (p=0.005). In summary, in cancer patients, the use of tumor markers for the decision of treatment might indicate the existence of any organ metastasis which could not be clinically or radiologically revealed.

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Primary Language

English

Subjects

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Journal Section

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Authors

Muharrem Bayrak This is me

Ömer Fatih Ölmez This is me

Ender Kurt This is me

Erdem Çubukcu This is me

Nilüfer Avcı This is me

Sinem Çubukcu This is me

Pınar Söker This is me

Osman Manavoğlu This is me

Publication Date

September 1, 2011

Submission Date

September 1, 2011

Acceptance Date

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Published in Issue

Year 2011 Volume: 37 Number: 3

IZ

https://izlik.org/JA79SP53BE

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RIS / Bibtex
APA
Bayrak, M., Ölmez, Ö. F., Kurt, E., Çubukcu, E., Avcı, N., Çubukcu, S., Söker, P., & Manavoğlu, O. (2011). The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer. Journal of Uludağ University Medical Faculty, 37(3), 139-143. https://izlik.org/JA79SP53BE
AMA
1.Bayrak M, Ölmez ÖF, Kurt E, et al. The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer. Journal of Uludağ University Medical Faculty. 2011;37(3):139-143. https://izlik.org/JA79SP53BE
Chicago
Bayrak, Muharrem, Ömer Fatih Ölmez, Ender Kurt, et al. 2011. “The Relationship Between Pre-Treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients With Locally Advanced and Metastatic Gastric Cancer”. Journal of Uludağ University Medical Faculty 37 (3): 139-43. https://izlik.org/JA79SP53BE.
EndNote
Bayrak M, Ölmez ÖF, Kurt E, Çubukcu E, Avcı N, Çubukcu S, Söker P, Manavoğlu O (September 1, 2011) The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer. Journal of Uludağ University Medical Faculty 37 3 139–143.
IEEE
[1]M. Bayrak et al., “The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer”, Journal of Uludağ University Medical Faculty, vol. 37, no. 3, pp. 139–143, Sept. 2011, [Online]. Available: https://izlik.org/JA79SP53BE
ISNAD
Bayrak, Muharrem - Ölmez, Ömer Fatih - Kurt, Ender - Çubukcu, Erdem - Avcı, Nilüfer - Çubukcu, Sinem - Söker, Pınar - Manavoğlu, Osman. “The Relationship Between Pre-Treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients With Locally Advanced and Metastatic Gastric Cancer”. Journal of Uludağ University Medical Faculty 37/3 (September 1, 2011): 139-143. https://izlik.org/JA79SP53BE.
JAMA
1.Bayrak M, Ölmez ÖF, Kurt E, Çubukcu E, Avcı N, Çubukcu S, Söker P, Manavoğlu O. The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer. Journal of Uludağ University Medical Faculty. 2011;37:139–143.
MLA
Bayrak, Muharrem, et al. “The Relationship Between Pre-Treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients With Locally Advanced and Metastatic Gastric Cancer”. Journal of Uludağ University Medical Faculty, vol. 37, no. 3, Sept. 2011, pp. 139-43, https://izlik.org/JA79SP53BE.
Vancouver
1.Muharrem Bayrak, Ömer Fatih Ölmez, Ender Kurt, Erdem Çubukcu, Nilüfer Avcı, Sinem Çubukcu, Pınar Söker, Osman Manavoğlu. The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer. Journal of Uludağ University Medical Faculty [Internet]. 2011 Sep. 1;37(3):139-43. Available from: https://izlik.org/JA79SP53BE

ISSN: 1300-414X, e-ISSN: 2645-9027

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