Ketogenic Diet and Cancer

Yıl 2025, Cilt: 18 Sayı: 1, 80 - 85, 30.04.2025

Duygu Doğan , Emine Okumuş , İsmet Meydan

https://doi.org/10.52976/vansaglik.1621908

Öz

The ketogenic diet is a diet implemented with high fat consumption and adequate protein by reducing glucose and increasing ketone bodies. Ketogenic diet; It is recommended as an effective intervention on diseases such as diabetes, obesity, cardiovascular diseases and cancer. The ketogenic diet is a diet with high fat and low protein by reducing glucose and increasing ketone bodies. Ketogenic diet; It is recommended as an effective intervention on diseases such as diabetes, obesity, cardiovascular diseases and cancer. In experimental models and clinical studies, the ketogenic diet has an antitumor effect by reducing energy sources to cells and preventing tumor growth. Cancer cells use the Warburg effect on ketogenic diet metabolism. Aerobically dominant glucose utilization may be a possible pathway to be targeted during cancer therapy. Research emphasizes that the integration of the ketogenic diet with the traditional treatment protocol will show positive results on the antitumor effect of chemotherapy. This review provides evidence for understanding the mechanism of action of the ketogenic diet on cancer treatment and its therapeutic use.

Anahtar Kelimeler

cancer , ketogenic diet , antitumor , warburg effect.

Ketojenik Diyet ve Kanser

Öz

Ketojenik diyet, glikozu azaltıp keton cisimlerini arttırarak yüksek yağ kullanımı ve yeterli miktarda protein ile uygulanan bir diyettir. Ketojenik diyet; diyabet, obezite, kardiyovasküler rahatsızlıklar ve kanser gibi hastalıklar üzerinde etkili bir müdahale olarak önerilmektedir. Deneysel modellerde ve klinik çalışmalarda ketojenik diyet, hücrelere giden enerji kaynaklarını azaltıp tümör büyümesini engelleyerek, antitümör etki göstermektedir. Kanser hücreleri ketojenik diyet metabolizması üzerinde Warburg etkisini kullanmaktadır. Aerobik olarak baskın glikoz kullanımı, kanser tedavisi sırasında hedef alınması gereken muhtemel bir yol olabilir. Araştırmalar ketojenik diyetin, uygulanan geleneksel tedavi protokolü ile bütünleşmesinin kemoterapinin antitümör etkisi üzerinde olumlu sonuçlar göstereceğini vurgulamaktadır. Bu derleme, ketojenik diyetin kanser tedavisi üzerindeki etki mekanizmasını anlamak ve terapötik olarak kullanımına ilişkin kanıtlar sunmaktadır.

Anahtar Kelimeler

kanser , ketojenik diyet , antitümör , warburg etkisi

Kaynakça

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