Dirençli bakterilerle komplike köpek kronik yangısal pododermatit: klinik vaka serileri

Year 2022, Volume: 93 Issue: 1, 59 - 64, 15.01.2022

Başar Ulaş Sayılkan Emre Küllük Merve Gizem Sezener Ümit Özcan Arzu Findik Duygu Dalgın Yücel Meral

https://doi.org/10.33188/vetheder.951118

Abstract

Pododermatit, tırnak derisinin, interdigital boşluğun, taban pedlerinin ve tırnak kıvrımlarının yangısı olarak tanımlanır. Pedal foliküliti ve furunküloz olarak bilinen karmaşık durumlar, çok faktörlü yapıları nedeniyle sıklıkla karmaşık tanı ve tedavi gerektirir. Kronik ve ilerleyici pododermatit semptomları gösteren dört köpek, Ondokuzmayıs Üniversitesi Hayvan Hastanesi'ne getirildi. Eksüdatların bakteriyolojik incelemesi, Alman Çoban, Labrador Retriever ve Setter ırkı köpeklerde Metisiline Dirençli Staphylococcus aureus (MRSA) enfeksiyonu ortaya konuldu. MRSA izolatı sırasıyla sadece teikoplanin, gentamisin ve enrofloksasine duyarlı olark bulundu. Melez ırk köpekte, ampisilin/sulbaktama duyarlı Vankomisin Dirençli Enterococcus spp. izole edildi. Antinükleer Antikor Testleri yüksek pozitif titreler ortaya çıkardı. Her bir köpeğe duyarlı antibiyotikler prednizolon tedavisi kombinasyonu ile birlikte kullanılması önemli bir iyileşme sağladı. Sonuç olarak, köpeklerde kronik pododermatit vakalarında antibiyotiğe dirençli bakteriler ve immünomodülatör yanıt veren etiyoloji birlikte değerlendirilmelidir.

Keywords

Köpek, Pododermatit, Dirençli Bakteri, İmmunmodülatör

Canine chronic inflammatory pododermatitis complicated with resistant bacteria: clinical case series

Abstract

Pododermatitis is defined as the inflammation of the paw skin of nails, interdigital space, base pads, and nail folds. Complex conditions known as pedal folliculitis and furunculosis often need complicated diagnosis and treatment because of their multifactorial nature. Four dogs with symptoms of chronic and progressive pododermatitis were admitted to the Ondokuzmayis University Animal Hospital. Bacteriological examination of exudates revealed Methicillin Resistant Staphylococcus aureus (MRSA) infection in German Shepherd, Labrador Retriever and Setter dogs. The MRSA isolate was sensitive only to teicoplanin, gentamicin and enrofloxacin, respectively. From the infection of the mixed-breed dog, ampicillin/sulbactam susceptible Vancomycin-Resistant Enterococcus spp. was isolated. Antinuclear Antibody Tests revealed high positive titers. The use of antibiotics sensitive for each dog together with the combination of prednisolone treatment resulted in significant recovery. In conclusion, antibiotic-resistant bacteria and immunomodulatory responsive etiology should be considered together in cases of chronic pododermatitis in dogs.

Keywords

dog, pododermatitis, immunomodulatory, resistant bacteria

References

• Hnilica K.A. Bacterial Skin Diseases, In: Hnilica K.A. (editors). Small Animal Dermatology (Third Edition), W.B. Saunders, 2011. p. 37-82.
• Miller W.H., Griffin C.E., Campbell K.L. Bacterial Skin Diseases, In: Miller W.H., Griffin C.E., Campbell K.L. editor(s). Muller and Kirk’s Small Animal Dermatology (7th Edn) Elsevier, 2012. p.201–203.
• Breathnach R.M., Fanning S., Mulcahy G., Bassett H.F., Jones B.R. Canine pododermatitis and idiopathic disease. Vet J 2008;176:146-157.
• Duclos D. Canine pododermatitis. Vet Clin North Am Small Anim Pract 43(1):57-87. 5) Bajwa J. Canine pododermatitis. Can Vet J 2016;57:991-993.
• Swaim S.F., Lee A.H., MacDonald J.M., Angarano D.W., Cox N.R., Hathcock J.T. Fusion podoplasty for the treatment of chronic fibrosing interdigital pyoderma in the dog. Journal of the American Animal Hospital Association 1991;27:264–274.
• Reichlin M. Diagnosis criteria and serology. In: Clinical Management of Systemic Lupus Erythematosus. Schur, PH (Ed), Grune and Stratton, New York: 49;1983.
• Phan T.G., Wong R.C.W., Adelstein S. Autoantibodies to Extractable Nuclear Antigens: Making Detection and Interpretation More Meaningful. Clinical and Diagnostic Laboratory Immunology 2002;9:1-7.
• Hansson-Hamlin H., Lilliehöök I., Trowald-Wigh G. (2006) Subgroups of canine antinuclear antibodies in relation to laboratory and clinical findings in immune-mediated disease. Veterinary Clinical Pathology 2006;35:397-404.
• Ciftci A., Findik A., Onuk E.E., Savasan S. Detection of methicillin resistance and slime factor production of Staphylococcus aureus in bovine mastitis. Braz J Microbiol 2009;40:254-261.
• Dezfulian A., Aslani M.M., Oskoui M., Farrokh P., Azimirad M., Dabiri H., Salehian M.T., Zali M.R. Identification and Characterization of a High Vancomycin-Resistant Staphylococcus aureus Harboring Van A Gene Cluster Isolated from Diabetic Foot Ulcer. Iran J Basic Med Sci 2012;15:803-806.
• Abbey T.C., Deak E. What's New from the CLSI Subcommittee on Antimicrobial Susceptibility Testing M100, 29th Edition. Clinical Microbiology Newsletter 2009;41:203-209.
• Breathnach R.M., Baker K.P., Quinn P.J., McGeady T.A., Aherne C.M., Jones B.R. Clinical, immunological and histopathological findings in a subpopulation of dogs with pododermatitis. Vet Dermatol 2005;16:364-372.
• Papazoglou L.G., Ellison G.W., Farese J.P., Bellah J.R., Coomer A.R., Lewis D.D. Fusion Podoplasty for the Management of Chronic Pedal Conditions in Seven Dogs and One Cat. J Am Anim Hosp Assoc 2011;47: e199-205.
• Fındık A., Çiftci A., Önyay T., Sezener M.G., Koçak Y., Gülhan T. Determination of methicillin resistance and some genotypic characteristics of staphylococci isolated from dogs and their owners. Turk J Vet Anim Sci 2018;42:549-555.
• Smee N.M., Harkin K.R., Wilkerson M.J. Measurement of serum antinuclear antibody titer in dogs with and without systemic lupus erythematosus 120 Cases (1997-2005). Journal of the American Veterinary Medical Association 2007;230:1180-1183.
• Bremer H.D., Lattwein E., Renneker S., Lilliehöök I., Rönnelid J., Hansson-Hamlin H. Identification of specific antinuclear antibodies in dogs using a line immunoassay and enzyme-linked immunosorbent assay. Vet Immunol Immunopathol 2015;168:233-241.
• Breathnach R.M., Fanning S., Mulcahy G., Bassett H.F., Jones B.R., Daly P. Evaluation of Th1-like, Th2-like and immunomodulatory cytokine mRNA expression in the skin of dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis. Vet Dermatol 2006;17:313-321.
• Breathnach R.M., Fanning S., Mulcahy G., Bassett H.F., Strobl E., Jones B.D. “Cutaneous Infiltrates and Peripheral Blood Immune Responses in Dogs with Immunomodulatory-Responsive Lymphocytic-Plasmacytic Pododermatitis.” Veterinary Dermatology 2010;21:383–392.