Year 2019, Volume 30, Issue 1, Pages 44 - 50 2019-06-30

Zencefil’in Antibakteriyal Etkisi (Antibacterial effect of Zingiber officinale (Ginger))

Çiğdem GÜCEYÜ [1] , Gülşen GONCAGÜL [2] , Elçin GÜNAYDIN [3] , Pınar AKPINAR [4]

34 52

Antibiyotiklerin artan kullanımı mikroorganizmaların direnç kazanmasına neden olmuştur. Bu durumda özellikle kolay elde edilebilen, daha az yan etkiye sahip bitki kaynaklı terapötik maddelere ihtiyaç duyulmaktadır.

Zingiber officinale eski çağlardan beri tüm dünyada doğrudan antimikrobiyal  etkinliğe sahip olması nedeniyle  bakteriyel enfeksiyonların tedavisinde kullanılmıştır.

Çalışmamızda Zingiber officinale bitkisinin Soxhlette hazırlanan etanol  ekstraktlarının, standart  Staphylococcus aureus (ATCC-25923), Escherichia coli (ATCC-25922) ve dirençli olduğu bilinen hastalardan izole edilmiş Acinetobacter baumannii ve Klebsiella pneumoniae etkenlerine karşı   antibakteriyel  aktivitesi ile, günümüzde kullanılan, ampisilin (AM), sefazolin (CZ), sefuroksim (CXM), meropenem (MEM),kolistin (CL), ofloksasin (OFX), sulfametoksazol/ trimetoprim (SXT), tetrasiklin (TE), gentamisinin (GM) etkilerinin  agar difüzyon yöntemi ile karşılaştırılması amaçlandı.

Bu çalışmada zencefil (Zingiber officinale)  ekstraktının tüm test edilmiş bakterilerden Staphylococcus aureus karşı 5 µL ,10 µL,15 µL ve 20 µL ekstrakt emdirilen diskler çevresinde sırasıyla 7mm,10mm,11mm,15mm inhibisyon zon çapları ile ekstraktın artan miktarlarıyla etkisinin fazlalaştığı gözlendi. Escherichia coli’de ise sadece 20 µL ekstrakt uygulanan disk çevresinde 7mm inhibisyon zon çapı saptandı. Diğer bakterilerde ise ekstraktın etkinliğinin görüldüğü bir inhibisyon zon çapı oluşmadı.

Sonuç olarak, Zingiber officinale’nin yapısındaki bileşiklerin Staphylococcus aureus  ve Escherichia coli’ye karşı doza bağlı olarak antibakteriyel etkinliğe sahip olması dolayısıyla ekstraktın MİK ve MBK üzerine çalışmaların yapılmasının faydalı olacağı düşüncesindeyiz.

Zencefil, Antibiyotik duyarlılığı, Antibakteriyal etki
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Primary Language tr
Subjects Veterinary
Journal Section Original Article
Authors

Orcid: 0000-0002-0242-4734
Author: Çiğdem GÜCEYÜ
Institution: BURSA ULUDAĞ ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0003-4331-9698
Author: Gülşen GONCAGÜL (Primary Author)
Institution: BURSA ULUDAĞ ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-5247-7578
Author: Elçin GÜNAYDIN
Institution: HİTİT ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0003-2828-5979
Author: Pınar AKPINAR
Institution: BURSA ULUDAĞ ÜNİVERSİTESİ
Country: Turkey


Dates

Publication Date: June 30, 2019

APA GÜCEYÜ, Ç , GONCAGÜL, G , GÜNAYDIN, E , AKPINAR, P . (2019). Zencefil’in Antibakteriyal Etkisi (Antibacterial effect of Zingiber officinale (Ginger)). Etlik Veteriner Mikrobiyoloji Dergisi, 30 (1), 44-50. Retrieved from http://dergipark.org.tr/evmd/issue/46765/556983