Yıl 2019, Cilt 4 , Sayı 3, Sayfalar 127 - 131 2019-12-01

Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study

Ufuk Memiş [1] , Erdem Karadeniz [2] , Müfide Nuran Akçay [3] , Nurinnisa Öztürk [4]


Aim:We aimed to evaluate the usage of Galectin-3, Hepsin andTTF-1 levels as a marker for the differentiation of malignant and benign in patients with thyroid nodules.

Metods:Study was done prospectively between January 2018 and April 2018 in the our clinic, in patients planned for operation due to thyroid nodule. Galectin-3, Hepsin andTTF-1 levels were measured in the pre-operative serum of the benign and malign groups. The measured levels are evaluated statistically to determine whether there was any significant difference between malignant and benign groups.

Results:When the levels of Galectin-3, Hepsin andTTF-1 in the malign and benign group were compared; There was a statistically significant difference inTTF-1 levels(p = .038), no significant difference was found in Hepsin and Galectin-3. When the macropapillary and micropapillary types were compared in the malign patient group, there was a significant difference between the Galectin-3 levels(p = .009), but no difference was found between Hepsin andTTF-1.

Conclusions:It was seen that the decrease of Galectin-3 level in thyroid papillary carcinoma could be effective in transformation from micro carcinoma to macro carcinoma, andTTF-1 could be an important marker at the differentiation between benign and  malign in thyroid nodules

Galectin-3, Hepsin, TTF-1, Thyroid malignancy
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Birincil Dil en
Konular Cerrahi
Bölüm Orjinal Makale
Yazarlar

Orcid: 0000-0003-3393-3301
Yazar: Ufuk Memiş (Sorumlu Yazar)
Kurum: Atatürk Üniversitesi Tıp Fakültesi Araştırma Hastanesi
Ülke: Turkey


Orcid: 0000-0001-6319-1754
Yazar: Erdem Karadeniz
Kurum: Atatürk Üniversitesi Tıp Fakültesi Araştırma Hastanesi
Ülke: Turkey


Orcid: 0000-0001-8470-1741
Yazar: Müfide Nuran Akçay
Kurum: Atatürk Üniversitesi Tıp Fakültesi Araştırma Hastanesi
Ülke: Turkey


Orcid: 0000-0002-7746-2700
Yazar: Nurinnisa Öztürk
Kurum: Atatürk Üniversitesi Tıp Fakültesi Araştırma Hastanesi
Ülke: Turkey


Destekleyen Kurum Atatürk Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi
Proje Numarası TTU-2018-6644
Tarihler

Yayımlanma Tarihi : 1 Aralık 2019

Bibtex @araştırma makalesi { acem568773, journal = {Archives of Clinical and Experimental Medicine}, issn = {}, eissn = {2564-6567}, address = {hırkai şerif mah. keçeci çeşmesi sok. doktorlar sitesi b blok 6/7 Fatih İstanbul Türkiye}, publisher = {Mustafa Hasbahçeci}, year = {2019}, volume = {4}, pages = {127 - 131}, doi = {10.25000/acem.568773}, title = {Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study}, key = {cite}, author = {Memiş, Ufuk and Karadeniz, Erdem and Akçay, Müfide Nuran and Öztürk, Nurinnisa} }
APA Memiş, U , Karadeniz, E , Akçay, M , Öztürk, N . (2019). Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study. Archives of Clinical and Experimental Medicine , 4 (3) , 127-131 . DOI: 10.25000/acem.568773
MLA Memiş, U , Karadeniz, E , Akçay, M , Öztürk, N . "Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study". Archives of Clinical and Experimental Medicine 4 (2019 ): 127-131 <https://dergipark.org.tr/tr/pub/acem/issue/50377/568773>
Chicago Memiş, U , Karadeniz, E , Akçay, M , Öztürk, N . "Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study". Archives of Clinical and Experimental Medicine 4 (2019 ): 127-131
RIS TY - JOUR T1 - Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study AU - Ufuk Memiş , Erdem Karadeniz , Müfide Nuran Akçay , Nurinnisa Öztürk Y1 - 2019 PY - 2019 N1 - doi: 10.25000/acem.568773 DO - 10.25000/acem.568773 T2 - Archives of Clinical and Experimental Medicine JF - Journal JO - JOR SP - 127 EP - 131 VL - 4 IS - 3 SN - -2564-6567 M3 - doi: 10.25000/acem.568773 UR - https://doi.org/10.25000/acem.568773 Y2 - 2019 ER -
EndNote %0 Archives of Clinical and Experimental Medicine Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study %A Ufuk Memiş , Erdem Karadeniz , Müfide Nuran Akçay , Nurinnisa Öztürk %T Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study %D 2019 %J Archives of Clinical and Experimental Medicine %P -2564-6567 %V 4 %N 3 %R doi: 10.25000/acem.568773 %U 10.25000/acem.568773
ISNAD Memiş, Ufuk , Karadeniz, Erdem , Akçay, Müfide Nuran , Öztürk, Nurinnisa . "Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study". Archives of Clinical and Experimental Medicine 4 / 3 (Aralık 2019): 127-131 . https://doi.org/10.25000/acem.568773
AMA Memiş U , Karadeniz E , Akçay M , Öztürk N . Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study. ACEM. 2019; 4(3): 127-131.
Vancouver Memiş U , Karadeniz E , Akçay M , Öztürk N . Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study. Archives of Clinical and Experimental Medicine. 2019; 4(3): 131-127.