Covid-19 hastalarında serum 25-OH vitamin D3 düzeyleri ve hastalık aktivitesine etkileri: Prospektif kesitsel bir çalışma

Yıl 2022, , 181 - 190, 31.12.2022

Dilay Eken Gedik , Gülseren Dost Sürücü

https://doi.org/10.30569/adiyamansaglik.1128161

Öz

Amaç: Çalışmamızda, Koronavirüs Hastalığı-19 (Covid-19) hastalarında D vitamini düzeyleri ile hastalık şiddeti, prognoz ve inflamasyon belirteçleri arasındaki ilişkiyi belirlemeyi amaçladık.

Gereç ve Yöntem: Hastanemizde Covid-19 tanısı ile yatırılan 100 hastanın serum 25-hidroksi vitamin D düzeyleri ile C-Reaktif Protein (CRP), D-Dimer, prokalsitonin, fibrinojen, ferritin düzeyleri ve Postero-anterior Akciğer grafisi ve Akciğer Bilgisayarlı Tomografi görüntüleri değerlendirildi.

Bulgular: D vitamini eksikliği ve yetersizliği olan hastaların D-Dimer düzeyleri ve CRP düzeyleri anlamlı derecede yüksekti (p<0,05). D vitamini düzeyleri ile akciğer tutulum oranı, yoğun bakım ihtiyacı, mortalite ve hastanede kalış süresi arasında anlamlı bir ilişki yoktu.

Sonuç: Covid-19’da, D vitamini düzeylerinin etkisine ilişkin belirsizlikler devam etmektedir ve daha fazla sayıda hastayı içeren, komorbiditeleri dışlayan, D vitamini tedavisini değerlendiren çok merkezli randomize kontrollü çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

Covid-19, D vitamini eksikliği, Hastalık şiddeti, Mortalite

Serum 25-OH vitamin D3 levels and effects on disease activity in Covid-19 patients: A prospective cross-sectional study

Öz

Aim: In our study, we aimed to determine the relationship between vitamin D levels and disease severity, prognosis and inflammation markers in Coronavirus Disease-19 (Covid-19).

Materials and Methods: Serum 25-hydroxy vitamin D, C-Reactive Protein (CRP), D-Dimer, procalcitonin, fibrinogen, ferritin levels and Postero-anterior Chest X-ray and Lung Computerized Tomography images of 100 patients hospitalized with the diagnosis of Covid-19 in our hospital were evaluated.

Results: D-Dimer and CRP levels of patients with vitamin D deficiency and insufficiency were significantly higher (p<0.05). There was no significant relationship between vitamin D levels and lung involvement rate, need for intensive care, mortality and length hospital stay.

Conclusion: Uncertainties regarding the effect of vitamin D levels in Covid-19 remain, and there is a need for multicenter randomized controlled studies that include a larger number of patients, exclude comorbidities, and evaluate vitamin D therapy.

Anahtar Kelimeler

Covid-19, Disease severity, Mortality, Vitamin D deficiency

Kaynakça

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