Sentezlenen bir kumarin türevi olan etil 7-hidroksi-2-imino-2H-kromen-3-karboksilatın'ın Bisfenol A ile indüklenen böbrek toksisitesi üzerine etkileri

Yıl 2024, , 1 - 9, 23.04.2024

Nadir Bilgin Akgül , Muhammed Mehdi Üremiş , Nuray Üremiş , Ebru Annaç , Rıfat Cesur Bozat , Murat Koca , Ahmet Özkaya , Elif Merve Betül Yanılmaz

https://doi.org/10.30569/adiyamansaglik.1373918

Öz

Amaç: Bu çalışmada sentezlenen kumarin etil 7-hidroksi-2-imino-2H-kromen-3 karboksilatın (CM) Bisfenol A'nın (BPA) renal toksisitesine karşı koruyucu etkinliğinin araştırılması amaçlandı.
Gereç ve Yöntem: CM molekülü, 2,4-dihidroksibenzaldehit ve etil siyanoasetat arasındaki reaksiyon yoluyla sentezlendi. Hayvan denemeleri için ratlar dört gruba ayrıldı: kontrol, BPA, CM ve BPA + CM. Böbrek dokusunda Toplam Antioksidan Durum (TAS), Toplam Oksidan Durum (TOS) ve Malondialdehit (MDA) seviyeleri değerlendirildi. Serum örnekleri Total-Native tiyol ve böbrek fonksiyon testi parametreleri açısından analiz edildi.
Bulgular: BPA ile tedavi edilen grupta TAS ve tiyol düzeylerinde önemli düşüşler, TOS ve MDA düzeylerinde ise artışlar görüldü. Ancak CM ile bu yan etkiler önemli ölçüde azaldı.
Sonuç: Bu çalışmada elde edilen sonuçlar CM molekülünün BPA kaynaklı böbrek toksisitesine karşı koruyucu etkiye sahip olduğunu göstermektedir.

Anahtar Kelimeler

Bisfenol A, Kumarin, Böbrek, Antioksidan, Oksidatif stres

Etik Beyan

Ethical approval for this study was obtained from the Department of Animal Experiments Local Ethics Committee of Adıyaman University (Decision No: 2022/072). The welfare and living conditions of the animals used in the research fully complied with ethical standards.

Destekleyen Kurum

This study was supported by Adiyaman University Scientific Research Projects Unit (ADYUBAP, Project no. TIPFMAP/2022-0008)

Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

Öz

Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate (CM) against the renal toxicity of Bisphenol A (BPA).
Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPA+CM. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), and Malondialdehyde (MDA) levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters.
Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM.
Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.

Anahtar Kelimeler

Bisphenol A, Coumarin, Kidney, Antioxidant, Oxidative stres

Etik Beyan

Ethical approval for this study was obtained from the Department of Animal Experiments Local Ethics Committee of Adıyaman University (Decision No: 2022/072). The welfare and living conditions of the animals used in the research fully complied with ethical standards.

Destekleyen Kurum

This study was supported by Adiyaman University Scientific Research Projects Unit (ADYUBAP, Project no. TIPFMAP/2022-0008)

Kaynakça

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