COVID-19'lu çocuklarda ABO ve Rh kan gruplarının dağılımı ile klinik seyir arasındaki ilişki

Yıl 2021, , 32 - 37, 23.04.2021

Mehmet Gündüz , Hayrettin Temel

https://doi.org/10.30569/adiyamansaglik.889914

Öz

Amaç: Bu çalışma, ABO ve Rh kan gruplarının çocuklarda COVID-19 sıklığını ve semptom gelişimini etkileyip etkilemediğini araştırmayı amaçlamaktadır.
Gereç ve Yöntem: Çalışmaya SARS-CoV-2 PCR testi pozitif 337 çocuk ve kontrol grubu olarak 1286 sağlıklı çocuk dahil edildi.
Bulgular: Rh (+) çocuklarda hasta oranı, Rh (-) çocuklara göre anlamlı derecede yüksekti (p=0,006). Kan grubu A'nın, COVID-19 vakalarında semptom geliştirme için bir risk faktörü olduğu ve riski artırdığı bulunmuştur. Rh (+) kan grubunun COVID-19 için bağımsız bir risk faktörü olduğu ve COVID-19 vakalarının semptomatik olma oranını artırdığı bulunmuştur.
Sonuç: Çalışmamızdan elde edilen veriler, Rh pozitifliğinin çocukları hem COVID-19'a hem de COVID-19 durumunda semptomların gelişimine duyarlı hale getirdiğini ve kan grubu A'nın COVID-19 pozitif çocuklarda semptom geliştirme riskini artırdığını göstermektedir.

Anahtar Kelimeler

COVID-19, ABO, kan grubu, Rh, çocuk

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Laboratuvar çalışanları ve sorumlularına çok teşekkür ederim.

The relationship between the distribution of ABO and Rh blood groups and the clinical course in children with COVID-19

Öz

Aim: This study aims to investigate whether ABO and Rh blood groups affect the prevalence and symptom development of COVID-19 in children.
Materials and Methods: The study included 337 children with positive SARS-CoV-2 PCR test and 1286 healthy children as control group.
Results: The rate of patients in Rh (+) children was significantly higher than in Rh (-) children (p=0.006). Blood type A has been found to be a risk factor for developing symptoms in COVID-19 cases and increases the risk. It has been found that the Rh (+) blood group is an independent risk factor for COVID-19 and increases the rate of being symptomatic of COVID-19 cases.
Conclusion: The findings of our study show that Rh positivity renders children sensitive to the development of clinical symptoms both against COVID-19 and in the case of COVID-19, and blood type A increases the risk of developing symptoms in children with COVID-19.

Anahtar Kelimeler

COVID-19, ABO, Blood group, Rh, Child

Proje Numarası

Yok

Kaynakça

• Sankar J, Dhochak N, Kabra SK, Lodha R. COVID-19 in Children: Clinical Approach and Management. Indian J Pediatr. 2020;87(6):433-442.
• Tezer H, Bedir Demirdağ T. Novel coronavirus disease (COVID-19) in children. Turk J Med Sci. 2020;50(SI-1):592-603.
• AbdelMassih AF, Mahrous R, Taha A, Saud A, Osman A, Kamel B, et al. The potential use of ABO blood group system for risk stratification of COVID-19. Med Hypotheses. 2020;145:110343.
• Fan Q, Zhang W, Li B, Li DJ, Zhang J, Zhao F. Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan. Front Cell Infect Microbiol. 2020;10:404.
• Wu BB, Gu DZ, Yu JN, Yang J, Shen WQ. Association between ABO blood groups and COVID-19 infection, severity and demise: A systematic review and meta-analysis. Infect Genet Evol. 2020;84:104485.
• Abdollahi A, Mahmoudi-Aliabadi M, Mehrtash V, Jafarzadeh B, Salehi M. The Novel Coronavirus SARS-CoV-2 Vulnerability Association with ABO/Rh Blood Types. Iran J Pathol. 2020;15(3):156-160.
• Rahim F, Amin S, Bahadur S, Noor M, Mahmood A, Gul H. ABO / Rh-D Blood types and susceptibility to Corona Virus Disease-19 in Peshawar. Pakistan. Pak J Med Sci. 2021;37(1):4-8.
• Bhandari P, Durrance RJ, Bhuti P, Salama C. Analysis of ABO and Rh Blood Type Association With Acute COVID-19 Infection in Hospitalized Patients: A Superficial Association Among a Multitude of Established Confounders. J Clin Med Res. 2020;12(12):809-815.
• Latz CA, DeCarlo C, Boitano L, Png CYM, Patell R, Conrad MF, Eagleton M, Dua A. Blood type and outcomes in patients with COVID-19. Ann Hematol. 2020;99(9):2113-2118.
• Zietz M, Zucker J, Tatonetti NP. Testing the association between blood type and COVID-19 infection, intubation, and death. medRxiv [Preprint]. 2020 Apr 11:2020.04.08.20058073.
• Niles JK, Karnes HE, Dlott JS, Kaufman HW. Association of ABO/Rh with SARS-CoV-2 positivity: The role of race and ethnicity in a female cohort. Am J Hematol. 2021;96(1):E23-E26.
• Dzik S, Eliason K, Morris EB, Kaufman RM, North CM. COVID-19 and ABO blood groups. Transfusion. 2020;60(8):1883-1884.
• Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta. 2020;509:220-223.
• Zaidi FZ, Zaidi ARZ, Abdullah SM, Zaidi SZA. COVID-19 and the ABO blood group connection. Transfus Apher Sci. 2020;59(5):102838.
• Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, et al. Relationship between the ABO Blood Group and the COVID-19 Susceptibility. Clin Infect Dis. 2020 Aug 4:ciaa1150.
• Hoiland RL, Fergusson NA, Mitra AR, Griesdale DEG, Devine DV, Stukas S, et al. The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19. Blood Adv. 2020;4(20):4981-4989.
• Padhi S, Suvankar S, Dash D, Panda VK, Pati A, Panigrahi J, Panda AK. ABO blood group system is associated with COVID-19 mortality: An epidemiological investigation in the Indian population. Transfus Clin Biol. 2020;27(4):253-258.
• Dai X. ABO blood group predisposes to COVID-19 severity and cardiovascular diseases. Eur J Prev Cardiol. 2020;27(13):1436-1437.