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Akut ı̇skemik serebrovasküler olayda trombosit ı̇ndekslerinin tanısal değerinin ı̇ncelenmesi

Yıl 2020, Cilt 6, Sayı 1, 106 - 110, 23.04.2020
https://doi.org/10.30569/adiyamansaglik.537624

Öz

Amaç: Akut inmelerin (serebrovasküler olay) çoğu iskemiktir. Bu çalışmanın amacı akut iskemik serebrovasküler olaylarda (SVO) Platelet Sayısı (PC), Ortalama Platelet Hacmi (MPV) ve MPV/PC oranının tanısal değerini araştırmaktır.
Gereç ve Yöntem: Hastalar, hastanenin elektronik kayıt sistenmi üzerinden ICD kodları ve epikrizleri ile tarandı. Tespit edilen hastalar grup 1 (SVO’lu grup) ve grup 2 (SVO’lu olmayan grup) olmak üzere iki gruba ayrıldı.
Bulgular: Hastalık grubundaki PC değeri (250,67±93,16×103/L) iken kontrol grubunda (226,53±57.86×103/L) belirlenmiştir. Hastalık grubunun ortalama PC değeri daha yüksek bulunmuştur (p<0,05). MPV değerleri ve MPV/PC oranları iki grup arasında anlamlı fark göstermemiştir (p>0,05).
Sonuç: MPV ve MPV/PC oranı SVO için ayırt edici parametreler değildir.

Kaynakça

  • 1.Go S, Worman DJ. “Stroke Syndromes” in Tintinalli JE, Stapczynski J, Ma OJ, et al (Editors). Tintinalli’s Emergency Medicine. 7th edition, The McGrew-Hill Companies, China, 2011: 1142–56
  • 2.Coppinger JA, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 2004; 103(6):2096-104.
  • 3.Elsayed AM, Mohamed GA. Mean platelet volume and mean platelet volume/platelet count ratio as a risk stratification tool in the assessment of severity of acute ischemic stroke. Alexandria Journal of Medicine. 2017; 53(1), 67-70.
  • 4.D'erasmo E, Aliberti G, Celi FS, Romagnoli E, Vecci E, Mazzuoli GF. Platelet count mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med. 1990; 227(1): 11-4.
  • 5.Quan W, Chen Z, Yang X, et al. Mean platelet volume/platelet count ratio as a predictor of 90-day outcome in large artery atherosclerosis stroke patients. Int J Neurosci. 2017; 127(11): 1019-27.
  • 6.Ates S, Oksuz H, Dogu B, Bozkus F, Ucmak H, Yanıt F. Can mean platelet volume and mean platelet volume/platelet count ratio be used as a diagnostic marker for sepsis and systemic inflammatory response syndrome? Saudi Med J. 2015; 36(10): 1186.
  • 7.Han JS, Park TS, Cho SY, Joh JH, Ahn HJ. Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis. Platelets. 2012; 24(8): 590–3.
  • 8.Bolat I, Akgul O, Cakmak HA, et al. The prognostic value of admission mean platelet volume to platelet count ratio in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Kardiol Pol. 2016; 74(4): 346-55.
  • 9.Mayda-Domaç F, Mısırlı H, Yılmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis. 2010;19(1): 66-72.
  • 10.Du J, Wang Q, He B, et al. Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke. Int J Lab Hematol. 2016; 38(3): 233-9.
  • 11.Regev A, Stark P, Blickstein D, Lahav M. Thrombotic complications in essential thrombocythemia with relatively low platelet counts. Am J Hematol. 1997; 56(3): 168-72.
  • 12.van der Bom JG, Heckbert SR, Lumley T, et al. Platelet count and the risk for thrombosis and death in the elderly. J Thromb Haemost. 2009;7(3): 399-405.
  • 13.Griesshammer M, Bangerter M, Sauer T, Wennauer R, Bergmann L, Heimpel H. Aetiology and clinical significance of thrombocytosis: analysis of 732 patients with an elevated platelet count. J Intern Med. 1999; 245(3): 295-300.
  • 14.Cho SY, Jeon YL, Choi S K, Suh JT, Lee HJ, Park TS. Mean platelet volume in Korean patients with acute ischemic stroke: a gender difference. Platelet. 2013; 24(1): 75-6.
  • 15.Braekkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB. Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study. J Thromb Haemost. 2010; 8(1): 157-62.
  • 16.Arikanoglu A, Yucel Y, Acar A, Cevik MU, Akil E, Varol S. The relationship of the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients. Eur Rev Med Pharmacol Sci. 2013; 17(13): 1774-7
  • 17.Balcik ÖS, Bilen S, Ulusoy E, et al. Thrombopoietin and mean platelet volume in patients with ischemic stroke. Clin Appl Thromb Hemost. 2013; 19(1): 92-5.
  • 18.Nadar SK, Lip GY, Blann AD. Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke. Thromb Haemost. 2004; 92(06) :1342-8.
  • 19.Lok U, Gulacti U, Ekmekci B, Bulut T, Celik M. Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke. Neurosciences (Riyadh). 2017;22(2):119–126.
  • 20.Guenancia C, Hachet O, Stamboul K, et al. Incremental predictive value of mean platelet volume/platelet count ratio in in-hospital stroke after acute myocardial infarction. Platelet. 2017; 28(1): 54-9.

Evaluation of the diagnostic value of platelet indices in acute ischemic cerebrovascular event

Yıl 2020, Cilt 6, Sayı 1, 106 - 110, 23.04.2020
https://doi.org/10.30569/adiyamansaglik.537624

Öz

Aim: The majority of acute strokes (cerebrovascular event) are ischemic. The aim of this study was to investigate the diagnostic value of Platelet Count (PC), Mean Platelet Volume (MPV) and the MPV/PC ratio in acute ischemic cerebrovascular event (CVE).
Materials and Methods: Patients were searched on the electronic records of hospital by ICD codes and epicrises. The patients who detected were divided in two group that group 1 (CVE group) and group 2 (non-CVE group).
Results: The PC value in the group 1 was determined as (250.67±93.16×103/L) and in the group 2 as (226.53±57.86×103/L). The mean PC value of the group 1 was found to be higher (p<0,05). MPV values and the MPV/PC ratios showed no significant difference between the two groups (p>0,05).   
Conclusion: MPV and the MPV/PC ratio, which are not distinguished parameters for CVE.

Kaynakça

  • 1.Go S, Worman DJ. “Stroke Syndromes” in Tintinalli JE, Stapczynski J, Ma OJ, et al (Editors). Tintinalli’s Emergency Medicine. 7th edition, The McGrew-Hill Companies, China, 2011: 1142–56
  • 2.Coppinger JA, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 2004; 103(6):2096-104.
  • 3.Elsayed AM, Mohamed GA. Mean platelet volume and mean platelet volume/platelet count ratio as a risk stratification tool in the assessment of severity of acute ischemic stroke. Alexandria Journal of Medicine. 2017; 53(1), 67-70.
  • 4.D'erasmo E, Aliberti G, Celi FS, Romagnoli E, Vecci E, Mazzuoli GF. Platelet count mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med. 1990; 227(1): 11-4.
  • 5.Quan W, Chen Z, Yang X, et al. Mean platelet volume/platelet count ratio as a predictor of 90-day outcome in large artery atherosclerosis stroke patients. Int J Neurosci. 2017; 127(11): 1019-27.
  • 6.Ates S, Oksuz H, Dogu B, Bozkus F, Ucmak H, Yanıt F. Can mean platelet volume and mean platelet volume/platelet count ratio be used as a diagnostic marker for sepsis and systemic inflammatory response syndrome? Saudi Med J. 2015; 36(10): 1186.
  • 7.Han JS, Park TS, Cho SY, Joh JH, Ahn HJ. Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis. Platelets. 2012; 24(8): 590–3.
  • 8.Bolat I, Akgul O, Cakmak HA, et al. The prognostic value of admission mean platelet volume to platelet count ratio in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Kardiol Pol. 2016; 74(4): 346-55.
  • 9.Mayda-Domaç F, Mısırlı H, Yılmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis. 2010;19(1): 66-72.
  • 10.Du J, Wang Q, He B, et al. Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke. Int J Lab Hematol. 2016; 38(3): 233-9.
  • 11.Regev A, Stark P, Blickstein D, Lahav M. Thrombotic complications in essential thrombocythemia with relatively low platelet counts. Am J Hematol. 1997; 56(3): 168-72.
  • 12.van der Bom JG, Heckbert SR, Lumley T, et al. Platelet count and the risk for thrombosis and death in the elderly. J Thromb Haemost. 2009;7(3): 399-405.
  • 13.Griesshammer M, Bangerter M, Sauer T, Wennauer R, Bergmann L, Heimpel H. Aetiology and clinical significance of thrombocytosis: analysis of 732 patients with an elevated platelet count. J Intern Med. 1999; 245(3): 295-300.
  • 14.Cho SY, Jeon YL, Choi S K, Suh JT, Lee HJ, Park TS. Mean platelet volume in Korean patients with acute ischemic stroke: a gender difference. Platelet. 2013; 24(1): 75-6.
  • 15.Braekkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB. Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study. J Thromb Haemost. 2010; 8(1): 157-62.
  • 16.Arikanoglu A, Yucel Y, Acar A, Cevik MU, Akil E, Varol S. The relationship of the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients. Eur Rev Med Pharmacol Sci. 2013; 17(13): 1774-7
  • 17.Balcik ÖS, Bilen S, Ulusoy E, et al. Thrombopoietin and mean platelet volume in patients with ischemic stroke. Clin Appl Thromb Hemost. 2013; 19(1): 92-5.
  • 18.Nadar SK, Lip GY, Blann AD. Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke. Thromb Haemost. 2004; 92(06) :1342-8.
  • 19.Lok U, Gulacti U, Ekmekci B, Bulut T, Celik M. Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke. Neurosciences (Riyadh). 2017;22(2):119–126.
  • 20.Guenancia C, Hachet O, Stamboul K, et al. Incremental predictive value of mean platelet volume/platelet count ratio in in-hospital stroke after acute myocardial infarction. Platelet. 2017; 28(1): 54-9.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Araştırma Makalesi
Yazarlar

Mustafa BOĞAN (Sorumlu Yazar)
GAZİANTEP ŞEHİTKAMİL DEVLET HASTANESİ
0000-0002-3238-1827
Türkiye


Yılmaz SAFİ Bu kişi benim
KAHRAMANMARAŞ NECİP FAZIL ŞEHİR HASTANESİ
0000-0001-8116-3116
Türkiye


Mehmet Murat OKTAY
HASAN KALYONCU ÜNİVERSİTESİ
0000-0002-3487-5417
Türkiye


Mustafa SABAK
GAZİANTEP NİZİP DEVLET HASTANESİ
0000-0003-2777-2003
Türkiye


Hasan GÜMÜŞBOĞA Bu kişi benim
GAZİANTEP ŞEHİTKAMİL DEVLET HASTANESİ
0000-0002-9913-2585
Türkiye

Yayımlanma Tarihi 23 Nisan 2020
Başvuru Tarihi 8 Mart 2019
Kabul Tarihi 10 Nisan 2020
Yayınlandığı Sayı Yıl 2020, Cilt 6, Sayı 1

Kaynak Göster

AMA Boğan M. , Safi Y. , Oktay M. M. , Sabak M. , Gümüşboğa H. Evaluation of the diagnostic value of platelet indices in acute ischemic cerebrovascular event. ADYÜ Sağlık Bilimleri Derg. 2020; 6(1): 106-110.