In vivo antianemic study of two species of Murva on Phenylhydrazine induced anaemia in rats

Yıl 2020, Cilt: 6 Sayı: 2, 243 - 247, 30.08.2020

Raju Asirvatham , Aparna Ann Mathew , Dawn V Tomy

https://doi.org/10.30569/adiyamansaglik.694909

Öz

Aim: The present study was carried out to evaluate the antianemic effects of methanol extracts of Marsdenia tenacissima and Sansevieria roxburghiana on Phenylhydrazine (PHZ) induced anaemia in rats.
Materials and Methods: PHZ (40mg/kg, i.p) injection was administered to all rats on Day 0 and Day 1 day except the group I. Group II was disease control, group III to IV treated with 100, 200 mg/Kg of methanol extract of M. tenacissima whereas group V & VI received 50, 100 mg/kg of methanol extract of S. roxburghiana. Group VII received the higher doses of both extracts continuously from the day 3 to 28. RBC, Haematocrit and Haemoglobin were analysed on day 0,2,7,14,21 and 28.
Results: Continuous 28 days oral administration extracts raised the RBC, haemoglobin, and Haematocrit periodically in rats which were treated with PHZ.
Conclusion: These plants possess antianemic activity and can be used for rapid recovery and management of anaemia.

Anahtar Kelimeler

Murva, Marsdenia tenacissima, Sansevieria roxburghiana, Phenylhydrazine, Antianemic activity

Sıçanlarda fenilhidrazin ile indüklenmiş anemi üzerine iki Murva türünün in vivo antianemik etkileri

Öz

Amaç: Bu çalışma, farelerde Marsdenia tenacissima ve Sansevieria roxburghiana'nın metanol ekstraktlarının fenilhidrazin (PHZ) ile indüklenen anemi üzerindeki antianemik etkilerini değerlendirmek için yapıldı.
Gereç ve Yöntem: Grup I hariç 0. ve 1. gün tüm sıçanlara PHZ (40 mg/kg, i.p) enjeksiyonu uygulandı. Grup II hastalık kontrolüdür, grup III ila IV, M. tenacissima'nın 100, 200 mg/kg metanol ekstraktı ile tedavi edilirken, grup V & VI 50, 100 mg/kg S. roxburghiana metanol ekstraktı almıştır. Grup VII, her iki ekstrakttan en yüksek dozları 3. ila 28. günler boyunca sürekli olarak aldı. Eritrosit, hematokrit ve hemoglobin 0, 2, 7, 14, 21 ve 28. günlerde analiz edildi.
Bulgular: PHZ ile tedavi edilen sıçanlarda periyodik olarak 28 günlük oral metanol ekstraktlarının alınması eritrosit, hematokrit ve hemoglobini yükseltti.
Sonuç: Bu bitkiler antianemik aktiviteye sahiptir ve aneminin hızlı iyileşmesi ve tedavisi için kullanılabilirler.

Anahtar Kelimeler

Murva, Marsdenia tenacissima, Sansevieria roxburghian, Fenilhidrazin, Antianemik aktivite

Kaynakça

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