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Güncel Çürük Doku Uzaklaştırma Stratejilerinin Değerlendirilmesi

Yıl 2024, Cilt: 10 Sayı: 3, 281 - 293, 30.12.2024

Öz

Uzun yıllar boyunca bulaşıcı bir hastalık olarak tanımlanmış olan diş çürüğü, günümüzde plak biyofilminde meydana gelen dinamik değişimler sonucu bakteriyel dengenin bozulmasına bağlı olarak oluşan ve bulaşıcı olmayan bir hastalık olarak tanımlanmaktadır. Enfeksiyöz hastalıkların bilinen patolojik evrelerinden farklı olarak diş çürüğünün oluşma ve ilerlemesinde birçok farklı faktör rol oynamakta ve bakteri bulaşı yerine bakteriyel metabolik aktivitenin etkin olduğu bilinmektedir. Diş çürüğü, günümüzde bakterilerin tamamen uzaklaştırılarak iyileştirilmesi mümkün olmayan bir hastalık olarak kabul edilmektedir.
Günümüzde çürük dokuların selektif olarak uzaklaştırılması önerilmektedir. Sığ ve orta derinlikteki lezyonlarda restoratif materyal için yeterli derinliğe izin verecek şekilde sıkı dentine kadar uzaklaştırma önerilirken; vital pulpaya sahip derin çürük lezyonlu dişlerde kavite sınırları sert dentinde olacak şekilde, kavite tabanında pulpayı ekspoze etmeden yumuşak dentinin bırakıldığı selektif uzaklaştırma önerilmektedir.
2015 yılında Uluslararası Çürük Uzlaşı İşbirliği (The International Caries Consensus Collaboration, ICCC) grubu, çürük lezyonlarının yönetiminde farklı stratejiler ile ilgili uzman görüşlerini oluşturmak amacıyla bir toplantı düzenlemiştir. Bu toplantıda çürük ile ilgili terminolojik farklılıkların giderilmesi amacıyla güncel tanımlamalar sunulmuş, çürük dentin dokusunu tanımlamada kullanılan histolojik terimlerin (nekrotik bölge, kontamine bölge, demineralize bölge, vb.) yerine bunların klinik sonuçlarını ifade eden terimlerin (yumuşak, kösele/kayışımsı, sıkı ve sert dentin) kullanılması önerilmiş ve çürük dokuların uzaklaştırılmasında farklı stratejiler tanıtılmıştır. Araştırmacılar, takip eden yıllarda konuyla ilgili yapılan çalışmalara ait sonuçları değerlendirerek güncellemeleri sunmuşlardır.
Bu makalede, ICCC tarafından oluşturulan uzman görüşleri ışığında çürük ile ilişkili en son tanımlamalar gözden geçirilmiş, güncel çürük temizleme stratejileri ile ilgili yapılan çalışmalar değerlendirilmiştir.

Kaynakça

  • Innes N, Schwendicke F, Frencken J. An Agreed Terminology for Carious Tissue Removal. Monogr Oral Sci. 2018;27:155-61.
  • Innes NP, Frencken JE, Bjorndal L, Maltz M, Manton DJ, Ricketts D, et al. Managing Carious Lesions: Consensus Recommendations on Terminology. Adv Dent Res. 2016;28(2):49-57.
  • Ricketts D, Innes N, Schwendicke F. Selective Removal of Carious Tissue. Monogr Oral Sci. 2018;27:82-91.
  • Schwendicke F, Frencken JE, Bjorndal L, Maltz M, Manton DJ, Ricketts D, et al. Managing Carious Lesions: Consensus Recommendations on Carious Tissue Removal. Adv Dent Res. 2016;28(2):58-67.
  • Rosier BT, De Jager M, Zaura E, Krom BP. Historical and contemporary hypotheses on the development of oral diseases: are we there yet? Front Cell Infect Microbiol. 2014;4:92.
  • Fitzgerald RJ, Keyes PH. Demonstration of the etiologic role of streptococci in experimental caries in the hamster. J Am Dent Assoc. 1960;61:9-19.
  • Emilson CG, Krasse B. Support for and implications of the specific plaque hypothesis. Scand J Dent Res. 1985;93(2):96-104.
  • Loesche WJ. Clinical and microbiological aspects of chemotherapeutic agents used according to the specific plaque hypothesis. J Dent Res. 1979;58(12):2404-12.
  • Murdoch-Kinch CA, McLean ME. Minimally invasive dentistry. J Am Dent Assoc. 2003;134(1):87-95.
  • Burke FJ. From extension for prevention to prevention of extension: (minimal intervention dentistry). Dent Update. 2003;30(9):492-8, 500, 2.
  • Walsh LJ, Brostek AM. Minimum intervention dentistry principles and objectives. Aust Dent J. 2013;58 Suppl 1:3-16.
  • Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res. 1994;8(2):263-71.
  • Schwendicke F. Contemporary concepts in carious tissue removal: A review. J Esthet Restor Dent. 2017;29(6):403-8.
  • Schwendicke F. Removing Carious Tissue: Why and How? Monogr Oral Sci. 2018;27:56-67.
  • Banerjee A, Frencken JE, Schwendicke F, Innes NPT. Contemporary operative caries management: consensus recommendations on minimally invasive caries removal. Br Dent J. 2017;223(3):215-22.
  • Takahashi N, Nyvad B. The role of bacteria in the caries process: ecological perspectives. J Dent Res. 2011;90(3):294-303.
  • Kleinberg I. A mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis. Crit Rev Oral Biol Med. 2002;13(2):108-25.
  • Machiulskiene V, Campus G, Carvalho JC, Dige I, Ekstrand KR, Jablonski-Momeni A, et al. Terminology of Dental Caries and Dental Caries Management: Consensus Report of a Workshop Organized by ORCA and Cariology Research Group of IADR. Caries Res. 2020;54(1):7-14.
  • Fontana M. Nonrestorative Management of Cavitated and Noncavitated Caries Lesions. Dent Clin North Am. 2019;63(4):695-703.
  • Corrêa APS, Ferreira P, Panzarini SR, Sonoda CK, Caliente EA, Poi WR. Histomorphometric analysis of the healing process after the replantation of rat teeth maintained in bovine milk whey and whole milk. Dent Traumatol. 2017;33(6):472-81.
  • Yu OY, Lam WY, Wong AW, Duangthip D, Chu CH. Nonrestorative Management of Dental Caries. Dent J (Basel). 2021;9(10):121.
  • Tedesco TK, Calvo AFB, Passaro AL, Araujo MP, Ladewig NM, Scarpini S, et al. Nonrestorative treatment of initial caries lesion in primary teeth: a systematic review and network meta-analysis. Acta Odontol Scand. 2022;80(1):1-8.
  • Bianchi RMD, Pascareli-Carlos AM, Floriano I, Raggio DP, Braga MM, Gimenez T, et al. Impact of nonrestorative cavity control on proximal carious lesions of anterior primary teeth on the tooth survival and patientcentered outcomes (CEPECO 2): study protocol for a noninferiority randomized clinical trial. BMC Oral Health. 2021;21(1):167.
  • van Strijp G, van Loveren C. No Removal and Inactivation of Carious Tissue: Non-Restorative Cavity Control. Monogr Oral Sci. 2018;27:124-36.
  • Santamaria RM, Innes NPT, Machiulskiene V, Schmoeckel J, Alkilzy M, Splieth CH. Alternative Caries Management Options for Primary Molars: 2.5-Year Outcomes of a Randomised Clinical Trial. Caries Res. 2017;51(6):605-14.
  • Ramamurthy P, Rath A, Sidhu P, Fernandes B, Nettem S, Fee P, et al. Sealants for preventing dental caries in primary teeth (Review). Cochrane Database of Systematic Reviews. 2022(2).
  • Kashbour W, Gupta P, Worthington HV, Boyers D. Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of children and adolescents. Cochrane Database Syst Rev. 2020;11(11):CD003067.
  • Carvalho JC, Dige I, Machiulskiene V, Qvist V, Bakhshandeh A, Fatturi-Parolo C, Maltz M. Occlusal Caries: Biological Approach for Its Diagnosis and Management. Caries Res. 2016;50(6):527-42.
  • Altoukhi DH, El-Housseiny AA. Hall Technique for Carious Primary Molars: A Review of the Literature. Dent J (Basel). 2020;8(1):11.
  • Duggal M, Gizani S, Albadri S, Kramer N, Stratigaki E, Tong HJ, et al. Best clinical practice guidance for treating deep carious lesions in primary teeth: an EAPD policy document. Eur Arch Paediatr Dent. 2022;23(5):659-66.
  • Tedesco TK, Reis TM, Mello-Moura ACV, Silva GSD, Scarpini S, Floriano I, et al. Management of deep caries lesions with or without pulp involvement in primary teeth: a systematic review and network meta-analysis. Braz Oral Res. 2020;35(35):e004.
  • Conrads G, About I. Pathophysiology of Dental Caries. Monogr Oral Sci. 2018;27:1-10.
  • Ricucci D, Siqueira JF, Jr., Rocas IN, Lipski M, Shiban A, Tay FR. Pulp and dentine responses to selective caries excavation: A histological and histobacteriological human study. J Dent. 2020;100:103430.
  • Kher MS, Rao A. Contemporary Treatment Techniques in Pediatric Dentistry. 1st ed. Springer Nature Switzerland AG; 2009. Chapter 2, Lesion Management: Selective Removal of Carious Tissue in Shallow, Moderately Deep, and Deep Carious Lesions; p.47-73
  • Zhong B, Peng C, Wang G, Tian L, Cai Q, Cui F. Contemporary research findings on dentine remineralization. J Tissue Eng Regen Med. 2015;9(9):1004- 16.
  • Cao CY, Mei ML, Li QL, Lo EC, Chu CH. Methods for biomimetic remineralization of human dentine: a systematic review. Int J Mol Sci. 2015;16(3):4615-27.
  • He L, Hao Y, Zhen L, Liu H, Shao M, Xu X, et al. Biomineralization of dentin. J Struct Biol. 2019;207(2):115-22.
  • Bjorndal L. Stepwise Excavation. Monogr Oral Sci. 2018;27:68-81.
  • Llena C, Hernandez M, Melo M, Sanz JL, Forner L. Follow-up of patients subjected to direct and indirect pulp capping of young permanent teeth. A retrospective study. Clin Exp Dent Res. 2021;7(4):429-35.
  • Bjorndal L, Fransson H, Bruun G, Markvart M, Kjaeldgaard M, Nasman P, et al. Randomized Clinical Trials on Deep Carious Lesions: 5-Year Follow-up. J Dent Res. 2017;96(7):747-53.
  • Schwendicke F, Meyer-Lueckel H, Dorfer C, Paris S. Failure of incompletely excavated teeth--a systematic review. J Dent. 2013;41(7):569-80.
  • Pereira MA, Santos-Junior RBD, Tavares JA, Oliveira AH, Leal PC, Takeshita WM, et al. No additional benefit of using a calcium hydroxide liner during stepwise caries removal: A randomized clinical trial. J Am Dent Assoc. 2017;148(6):369-76.
  • Frencken JE. Atraumatic restorative treatment and minimal intervention dentistry. Br Dent J. 2017;223(3):183- 9.
  • Dhar V, Pilcher L, Fontana M, Gonzalez-Cabezas C, Keels MA, Mascarenhas AK, et al. Evidence-based clinical practice guideline on restorative treatments for caries lesions: A report from the American Dental Association. J Am Dent Assoc. 2023;154(7):551-66 e51.
  • Schwendicke F, Walsh T, Lamont T, Al-Yaseen W, Bjorndal L, Clarkson JE, et al. Interventions for treating cavitated or dentine carious lesions. Cochrane Database Syst Rev. 2021;7(7):CD013039.
  • Labib ME, Hassanein OE, Moussa M, Yassen A, Schwendicke F. Selective versus stepwise removal of deep carious lesions in permanent teeth: a randomised controlled trial from Egypt-an interim analysis. BMJ Open. 2019;9(9):e030957.
  • Elhennawy K, Finke C, Paris S, Reda S, Jost- Brinkmann PG, Schwendicke F. Selective vs stepwise removal of deep carious lesions in primary molars: 24 months follow-up from a randomized controlled trial. Clin Oral Investig. 2021;25(2):645-52.
  • Manhas S, Pandit IK, Gugnani N, Gupta M. Comparative Evaluation of the Efficacy of Stepwise Caries Excavation vs Indirect Pulp Capping in Preserving the Vitality of Deep Carious Lesions in Permanent Teeth of Pediatric Patients: An In Vivo Study. Int J Clin Pediatr Dent. 2020;13(Suppl 1):S92-S7.

Evaluation of Current Caries Removal Strategies

Yıl 2024, Cilt: 10 Sayı: 3, 281 - 293, 30.12.2024

Öz

Dental caries, which has been defined as an communicable disease for many years, is now defined as a non-communicable disease that occurs due to disruption of the bacterial balance resulting from dynamic changes in the plaque biofilm. Bacterial metabolic activity is known to be effective instead of bacterial transmission in the formation and progression of dental caries. Dental caries is a multifactorial disease that cannot be treated by complete removal of bacteria.
For cavitated lesions, selective removal of carious tissues is recommended. In shallow and moderately deep lesions, dentists should aim to remove caries tissue to allow adequate depth for the restorative material. For deep lesions in teeth with vital pulps, leaving soft dentin in pulpo-proximal areas avoids pulp exposure, while peripherally hard tissue is retained to ensure sufficient mechanical support of restoration.
In 2015, The International Caries Consensus Collaboration (ICCC), presented updated definitions regarding cariology terminologies. Histological terms used to describe carious dentin tissue (necrotic zone, contaminated zone, demineralized zone, etc.) have been replaced by terms describing their clinical consequences (soft, leathery, firm and hard dentin). Additionally, different clinical recommendations are presented for carious tissue removal and management of cavitated carious lesions. The researchers evaluated the results of studies conducted on the subject in the subsequent years and provided the necessary updates.
The aim of this study was to review the current definitions of caries in light of the expert opinions established by the ICCC and to evaluate the current caries removal strategies.

Kaynakça

  • Innes N, Schwendicke F, Frencken J. An Agreed Terminology for Carious Tissue Removal. Monogr Oral Sci. 2018;27:155-61.
  • Innes NP, Frencken JE, Bjorndal L, Maltz M, Manton DJ, Ricketts D, et al. Managing Carious Lesions: Consensus Recommendations on Terminology. Adv Dent Res. 2016;28(2):49-57.
  • Ricketts D, Innes N, Schwendicke F. Selective Removal of Carious Tissue. Monogr Oral Sci. 2018;27:82-91.
  • Schwendicke F, Frencken JE, Bjorndal L, Maltz M, Manton DJ, Ricketts D, et al. Managing Carious Lesions: Consensus Recommendations on Carious Tissue Removal. Adv Dent Res. 2016;28(2):58-67.
  • Rosier BT, De Jager M, Zaura E, Krom BP. Historical and contemporary hypotheses on the development of oral diseases: are we there yet? Front Cell Infect Microbiol. 2014;4:92.
  • Fitzgerald RJ, Keyes PH. Demonstration of the etiologic role of streptococci in experimental caries in the hamster. J Am Dent Assoc. 1960;61:9-19.
  • Emilson CG, Krasse B. Support for and implications of the specific plaque hypothesis. Scand J Dent Res. 1985;93(2):96-104.
  • Loesche WJ. Clinical and microbiological aspects of chemotherapeutic agents used according to the specific plaque hypothesis. J Dent Res. 1979;58(12):2404-12.
  • Murdoch-Kinch CA, McLean ME. Minimally invasive dentistry. J Am Dent Assoc. 2003;134(1):87-95.
  • Burke FJ. From extension for prevention to prevention of extension: (minimal intervention dentistry). Dent Update. 2003;30(9):492-8, 500, 2.
  • Walsh LJ, Brostek AM. Minimum intervention dentistry principles and objectives. Aust Dent J. 2013;58 Suppl 1:3-16.
  • Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res. 1994;8(2):263-71.
  • Schwendicke F. Contemporary concepts in carious tissue removal: A review. J Esthet Restor Dent. 2017;29(6):403-8.
  • Schwendicke F. Removing Carious Tissue: Why and How? Monogr Oral Sci. 2018;27:56-67.
  • Banerjee A, Frencken JE, Schwendicke F, Innes NPT. Contemporary operative caries management: consensus recommendations on minimally invasive caries removal. Br Dent J. 2017;223(3):215-22.
  • Takahashi N, Nyvad B. The role of bacteria in the caries process: ecological perspectives. J Dent Res. 2011;90(3):294-303.
  • Kleinberg I. A mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis. Crit Rev Oral Biol Med. 2002;13(2):108-25.
  • Machiulskiene V, Campus G, Carvalho JC, Dige I, Ekstrand KR, Jablonski-Momeni A, et al. Terminology of Dental Caries and Dental Caries Management: Consensus Report of a Workshop Organized by ORCA and Cariology Research Group of IADR. Caries Res. 2020;54(1):7-14.
  • Fontana M. Nonrestorative Management of Cavitated and Noncavitated Caries Lesions. Dent Clin North Am. 2019;63(4):695-703.
  • Corrêa APS, Ferreira P, Panzarini SR, Sonoda CK, Caliente EA, Poi WR. Histomorphometric analysis of the healing process after the replantation of rat teeth maintained in bovine milk whey and whole milk. Dent Traumatol. 2017;33(6):472-81.
  • Yu OY, Lam WY, Wong AW, Duangthip D, Chu CH. Nonrestorative Management of Dental Caries. Dent J (Basel). 2021;9(10):121.
  • Tedesco TK, Calvo AFB, Passaro AL, Araujo MP, Ladewig NM, Scarpini S, et al. Nonrestorative treatment of initial caries lesion in primary teeth: a systematic review and network meta-analysis. Acta Odontol Scand. 2022;80(1):1-8.
  • Bianchi RMD, Pascareli-Carlos AM, Floriano I, Raggio DP, Braga MM, Gimenez T, et al. Impact of nonrestorative cavity control on proximal carious lesions of anterior primary teeth on the tooth survival and patientcentered outcomes (CEPECO 2): study protocol for a noninferiority randomized clinical trial. BMC Oral Health. 2021;21(1):167.
  • van Strijp G, van Loveren C. No Removal and Inactivation of Carious Tissue: Non-Restorative Cavity Control. Monogr Oral Sci. 2018;27:124-36.
  • Santamaria RM, Innes NPT, Machiulskiene V, Schmoeckel J, Alkilzy M, Splieth CH. Alternative Caries Management Options for Primary Molars: 2.5-Year Outcomes of a Randomised Clinical Trial. Caries Res. 2017;51(6):605-14.
  • Ramamurthy P, Rath A, Sidhu P, Fernandes B, Nettem S, Fee P, et al. Sealants for preventing dental caries in primary teeth (Review). Cochrane Database of Systematic Reviews. 2022(2).
  • Kashbour W, Gupta P, Worthington HV, Boyers D. Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of children and adolescents. Cochrane Database Syst Rev. 2020;11(11):CD003067.
  • Carvalho JC, Dige I, Machiulskiene V, Qvist V, Bakhshandeh A, Fatturi-Parolo C, Maltz M. Occlusal Caries: Biological Approach for Its Diagnosis and Management. Caries Res. 2016;50(6):527-42.
  • Altoukhi DH, El-Housseiny AA. Hall Technique for Carious Primary Molars: A Review of the Literature. Dent J (Basel). 2020;8(1):11.
  • Duggal M, Gizani S, Albadri S, Kramer N, Stratigaki E, Tong HJ, et al. Best clinical practice guidance for treating deep carious lesions in primary teeth: an EAPD policy document. Eur Arch Paediatr Dent. 2022;23(5):659-66.
  • Tedesco TK, Reis TM, Mello-Moura ACV, Silva GSD, Scarpini S, Floriano I, et al. Management of deep caries lesions with or without pulp involvement in primary teeth: a systematic review and network meta-analysis. Braz Oral Res. 2020;35(35):e004.
  • Conrads G, About I. Pathophysiology of Dental Caries. Monogr Oral Sci. 2018;27:1-10.
  • Ricucci D, Siqueira JF, Jr., Rocas IN, Lipski M, Shiban A, Tay FR. Pulp and dentine responses to selective caries excavation: A histological and histobacteriological human study. J Dent. 2020;100:103430.
  • Kher MS, Rao A. Contemporary Treatment Techniques in Pediatric Dentistry. 1st ed. Springer Nature Switzerland AG; 2009. Chapter 2, Lesion Management: Selective Removal of Carious Tissue in Shallow, Moderately Deep, and Deep Carious Lesions; p.47-73
  • Zhong B, Peng C, Wang G, Tian L, Cai Q, Cui F. Contemporary research findings on dentine remineralization. J Tissue Eng Regen Med. 2015;9(9):1004- 16.
  • Cao CY, Mei ML, Li QL, Lo EC, Chu CH. Methods for biomimetic remineralization of human dentine: a systematic review. Int J Mol Sci. 2015;16(3):4615-27.
  • He L, Hao Y, Zhen L, Liu H, Shao M, Xu X, et al. Biomineralization of dentin. J Struct Biol. 2019;207(2):115-22.
  • Bjorndal L. Stepwise Excavation. Monogr Oral Sci. 2018;27:68-81.
  • Llena C, Hernandez M, Melo M, Sanz JL, Forner L. Follow-up of patients subjected to direct and indirect pulp capping of young permanent teeth. A retrospective study. Clin Exp Dent Res. 2021;7(4):429-35.
  • Bjorndal L, Fransson H, Bruun G, Markvart M, Kjaeldgaard M, Nasman P, et al. Randomized Clinical Trials on Deep Carious Lesions: 5-Year Follow-up. J Dent Res. 2017;96(7):747-53.
  • Schwendicke F, Meyer-Lueckel H, Dorfer C, Paris S. Failure of incompletely excavated teeth--a systematic review. J Dent. 2013;41(7):569-80.
  • Pereira MA, Santos-Junior RBD, Tavares JA, Oliveira AH, Leal PC, Takeshita WM, et al. No additional benefit of using a calcium hydroxide liner during stepwise caries removal: A randomized clinical trial. J Am Dent Assoc. 2017;148(6):369-76.
  • Frencken JE. Atraumatic restorative treatment and minimal intervention dentistry. Br Dent J. 2017;223(3):183- 9.
  • Dhar V, Pilcher L, Fontana M, Gonzalez-Cabezas C, Keels MA, Mascarenhas AK, et al. Evidence-based clinical practice guideline on restorative treatments for caries lesions: A report from the American Dental Association. J Am Dent Assoc. 2023;154(7):551-66 e51.
  • Schwendicke F, Walsh T, Lamont T, Al-Yaseen W, Bjorndal L, Clarkson JE, et al. Interventions for treating cavitated or dentine carious lesions. Cochrane Database Syst Rev. 2021;7(7):CD013039.
  • Labib ME, Hassanein OE, Moussa M, Yassen A, Schwendicke F. Selective versus stepwise removal of deep carious lesions in permanent teeth: a randomised controlled trial from Egypt-an interim analysis. BMJ Open. 2019;9(9):e030957.
  • Elhennawy K, Finke C, Paris S, Reda S, Jost- Brinkmann PG, Schwendicke F. Selective vs stepwise removal of deep carious lesions in primary molars: 24 months follow-up from a randomized controlled trial. Clin Oral Investig. 2021;25(2):645-52.
  • Manhas S, Pandit IK, Gugnani N, Gupta M. Comparative Evaluation of the Efficacy of Stepwise Caries Excavation vs Indirect Pulp Capping in Preserving the Vitality of Deep Carious Lesions in Permanent Teeth of Pediatric Patients: An In Vivo Study. Int J Clin Pediatr Dent. 2020;13(Suppl 1):S92-S7.
Toplam 48 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Çocuk Diş Hekimliği
Bölüm Derleme
Yazarlar

Melis Yazır Kavan 0000-0001-7385-0637

Yeliz Güven 0000-0002-4637-6025

Yayımlanma Tarihi 30 Aralık 2024
Gönderilme Tarihi 29 Şubat 2024
Kabul Tarihi 30 Nisan 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 10 Sayı: 3

Kaynak Göster

Vancouver Yazır Kavan M, Güven Y. Güncel Çürük Doku Uzaklaştırma Stratejilerinin Değerlendirilmesi. Aydin Dental Journal. 2024;10(3):281-93.

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