Vücut sıvılarında Antemortem - Postmortem Etil Alkol Düzeyinin Belirlenmesinde Kullanılan Biyobelirteçler

Öz

Etil alkol kullanımı pek çok açıdan adli tıp pratiği ile çakışmaktadır. Bu durum etil alkol kullanımının ve postmortem üretiminin tespit edilmesini adli tıp açısından son derece önemli kılmaktadır. Buna karşın antemortem-postmortem alkol düzeylerinin belirlenmesinde klasik yöntemlerin pek çok durumda yetersiz kaldığı görülmektedir. Bu durum etil alkol kullanımının tespiti için ek yöntemlere ihtiyaç duyulmasına sebep olmaktadır. Gama Glutamil Transferaz, Ortalama Eritrosit Hacmi ve Karbonhidrat Takısı Eksik Transferrin gibi bazı yöntemlerin belli dezavantajlarının olması da kullanım alanlarını ve yararlarını sınırlamaktadır. Son yıllarda etanol kullanımının göstergesi olarak tanımlanan etil glukronid, etil sülfat, fosfatidiletanol, 5-hidroksitriptofol / 5-hidroksiindol asetik asit oranı ve yağ asidi etil esterleri gibi biyobelirteçlerin yararlılıkları pek çok çalışma ile kanıtlanmıştır. Bu derlemede, antemortem - postmortem etil alkol ayrımı konusunda bu tür yeni yöntemlerin kullanımının yaygınlaştırılmasının öneminin vurgulanması amaçlanmıştır.

Anahtar Kelimeler

• Etil alkol
• postmortem alkol üretimi
• etil glukronid
• etil sülfat
• fosfatidiletanol
• yağ asidi etil esterleri
• 5-Hidroksitriptofol/5-Hidroksiindol asetik asit oranı

Biomarkers Used to Determine Antemortem and Postmortem Ethyl Alcohol Level in Body Fluids

Öz

Consumption of ethyl alcohol has intersected with forensic science practice in many situations. This situation makes it highly important for forensic medicine to determine consumption and postmortem production of ethyl alcohol. For all that, classical methods can be insufficient to determine the antemortem and postmortem ethanol level in many situations. This causes a need for additional methods for the detection of ethyl alcohol. The presence of certain disadvantages of some methods such as Gama Glutamyl Transferase, Main Corpuscular Volume and Carbonhydrate Deficient Transferrin, it limits their utility and their usage areas. The usefulness of biomarkers such as ethyl glucuronide, ethyl sulfate, phosphatidylethanol, 5-Hydroxytryptophol/5-hydroxyindoleacetic acid ratio and fatty acid ethyl esters, which were determined as indicator of ethanol use in the last years has been proven in many studies. In the present review article, it was aimed that to emphasizing the importance of dissemination of using the similar new methods about identification of antemortem - postmortem ethanol.

Anahtar Kelimeler

• Ethyl alcohol
• postmortem alcohol production
• ethyl glucuronide
• ethyl sulfate
• phosphatidylethanol
• fatty acid ethyl esters
• 5-Hydroxytryptophol / 5-Hydroxyindoleacetic acid ratio

Kaynakça

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