Corrected TLC-Data of 16 Hydrolysis-Derivatives of Commonly Used Benzodiazepines in 10 Systems

Öz

In addition to the corrected Rf- values of 61 benzodiazepines and metabolites which were recently published in this journal [Adli Tıp Derg. (ATD), 1, 22-29 (1985)] we have investigated the corrected Rf- values of 16 hydrolysis products (aminobenzophenones and benzoylpyridines) in 10 (!) systems. These cleavage products may occur as metabolites in some cases and/or artefacts in biological materials. They are, in addition to this minor important fact, the basis of largely applied screening met hods.

Anahtar Kelimeler

• Benzodiazepines
• Metabolites
• Aminobenzophenones

Kaynakça

1. Sehütz, H., Sehneider, W.-R. (1985) Adli Tıp Derg. (ATD), 1, 22-29.
2. TIAFTjDFG (1987) Thin Layer Chromaıographic Rf- values of Toxicologically Relevant Subsıances on Sıandardised Sysıems. Prepared und er the auspiees of the Committee for Systeqıatie Toxieological Analysis of TIAFT by Moffat, A.C., Franke, J.-P., Stead, A.H., Gill, R., Finkle, B.S., Möller, M.R., Müller, R.K., Wunsch, F., de Zeeuw, R.A. Report VII of t he DFG-Commission for Clinical-Toxicological AnalysisjSpecial Issue of the TIAFT Bullet in. VCH-Verlagsgesellschaft, Weinheim.
3. Schütz, H. (1986) Dünnschichıchromaıographische Suchanalyse für 1,4-Benzodiazepine in Ham, Bluı und Mageninhaıı. Mitteilung VI der Senatskommission der DFG für Kliniseh-toxikologische Analytik. V CH -V erlagsgesellschaft, Weinheim.