Analysis of Drug Preparation Containing Chlorpropamide and Phenformin Hydrochloride by Thin-Layer Chromatography

Yıl 1987, Cilt: 3 Sayı: 1, 27 - 30, 30.04.1987

R .v. Gaitonde

https://izlik.org/JA72MD47RS

Öz

The pharmaccutical preparations are usually analyzed hy phannacopeial methods for their individual components, This in volves eithe r sophisti cated instruments or time consuming factors, Therefore a method was deve loped ıo analyze a phannaeeuıie l antidiahetic preparation in the fonn of a tahlet eontain ing chlorpropamide and phenfonnin hydrochloride. Th is involves, first, scraration of the individual components hy a simI'le thin-Iayer chromatog raphy (TLC), and then estimating the same hy spectroph otometric method (Shimadzu UV 240). Lite rature survey does not reveal any work on such ahove mention ed fonnulation, Therefore, the devised method was found simplc, economical and time saving.

Anahtar Kelimeler

Chlorpropamide , TLC analysis , Phenformin

Kaynakça

• Mill, H.M., Chamberlain, J. (1978) 1. Chr maıogr., 149, 349 .
• AlIesandra, A. Piari, M. Liguori, A. (1975) Chemical Abst., 82, 77 146 C.
• Wickramsinghe, J. A. F. Shaws, R. (1972) f . Chromatogr., 71, 265 - 273.
• Kshi, S.R. (1985) Chemical Abst., 104, 21851 5 j.
• Takla, P.G. Jeshi, S.R. (1984) Chemical Abst , 100, 56936 K.
• Zecca, L. Colombo, R. Fanetti, O.T. (1985) f . Chromatog r. , 339, 203.