SERUM FERRİTİN DÜZEYİ SAĞLIKLI BİREYLERLE YENİ TANI TİP 2 DİYABET HASTALARINDA FARKLI MIDIR?: VAKA KONTROL ÇALIŞMASI

Öz

Giriş: Bu çalışmanın amacı yeni tanı tip 2 DM hastaları ile sağlıklı bireyler arasında serum ferritin düzeyi açısından fark olup olmadığını değerlendirmek, ayrıca tip 2 DM hastalarında serum ferritin düzeyinin insülin direnci ve metabolik kontrol ile ilişkisini araştırmaktır. Materyal ve metod: Çalışmaya 40 yeni tanı tip 2 DM hastası ile 40 sağlıklı kişiden oluşan kontrol grubu dahil edildi. İnsülin direncini değerlendirmek için Homeostasis Model Assessment of insülin resistance (HOMA-IR) skoru kullanıldı. HOMA-IR skorunun ≥2,7 olması insulin direnci olarak kabul edildi. Hasta ve kontrol grubunu oluşturan bireyler yaş, cinsiyet dağılımı, VKİ, serum ferritin düzeyi, insülin düzeyi ve HOMA-IR skoru açısından karşılaştırıldı. Hasta grubundaki bireylerin ferritin düzeyi ile diğer parametreler arasındaki ilişki incelendi. Ayrica iyi metabolik kontrollü (HbA1c<%7) ve kötü metabolik kontrollü (HbA1c≥%7) hastaların serum ferritin düzeyleri karşılaştırıldı. Bulgular: Hasta grubunun %90’ında (n=36), kontrol grubunun %27,5’inde (n=11) HOMA-IR skoru ≥2,7 olarak tespit edildi. Hasta grubunun ferritin düzeyi kontrol grubuna göre anlamlı olarak yüksek saptandı (153,57±150,01’e 62,83±53,18; p=0,003). Hasta grubunda ferritin düzeyi ile açlık kan şekeri (r=0.419 p=0.007), HbA1c (r=0.410, p=0.009) ve HOMA-IR skoru (r=0.320, p=0.044) arasında pozitif bir korelasyon tespit edildi. Tip 2 DM hastalarında kötü metabolik kontrollü hastaların ortalama ferritin düzeyleri (201,20±170,67) iyi metabolik kontrollü hastaların ortalama ferritin düzeylerine (91,92±71,39) göre anlamlı olarak daha yüksek saptandı (p=0,047). Sonuç: Tip 2 DM hastalarında serum ferritin düzeyi sağlıklı bireylere göre yüksek saptanmış olup serum ferritin düzeyi ile insülin direnci arasında pozitif bir ilişki bulunmuştur.

Anahtar Kelimeler

• ferritin
• diabetes mellitus
• insülin dirsenci

Proje Numarası

none

IS SERUM FERRITIN LEVEL DIFFERENT BETWEEN HEALTHY INDIVIDUALS AND NEWLY DIAGNOSED PATIENTS WITH TYPE 2 DIABETES MELLITUS?: A CASE-CONTROL STUDY

Öz

Introduction: This study aims to evaluate whether serum ferritin levels differ between recently diagnosed patients with type 2 diabetes mellitus (DM) and healthy controls, and to assess the relationship between serum ferritin level, insulin resistance and metabolic control in patients with type 2 DM. Material and methods: This study included 40 patients with recently diagnosed type 2 DM and 40 healthy controls. The Homeostasis Model Assessment of insulin resistance (HOMA-IR) score was used for evaluation of insulin resistance. HOMA-IR scores ≥2.7 were accepted as insulin resistance. The patient and control groups were compared in terms of age, gender, BMI, serum ferritin, insulin, HbA1c, and HOMA-IR scores. If ferritin levels correlated with other parameters was assessed in the patient group. Furthermore, patients with good (HbA1c<7%) and poor glycemic control (HbA1c≥7%) were compared regarding serum ferritin level. Results: Ninety percent (n=36) of the patient group and 27.5% (n=11) of the controls had HOMA-IR scores ≥2.7. Serum ferritin levels were significantly higher in the patient group (153.57±150.01 vs 62.83±53.18; p=0.003). There were significant positive correlations between serum ferritin and fasting plasma glucose levels (r=0.419 p=0.007), HbA1c (r=0.410, p=0.009) and HOMA-IR score (r=0.320, p=0.044) in the patient group. Mean serum ferritin level of patients with poor metabolic control (201.20±170.67) was significantly higher than ones with good metabolic control (91.92±71.39) among patients with type 2 DM (p=0.047). Conclusion: Serum ferritin levels were found to be higher in patients with type 2 DM than controls and there was positive correlation between serum ferritin levels and insulin resistance.

Anahtar Kelimeler

• ferritin
• diabetes mellitus
• insulin resistance

Destekleyen Kurum

none

Proje Numarası

none

Teşekkür

Dr İsmihan SUNAR for her precious support

Kaynakça

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