Possible tigecycline related acute pancreatitis in an adult with cystic fibrosis

Öz

The aim of this case report is to increase the awareness of pancreatitis due to tigecycline, especially in patients with high risk. A 19-year-old male patient with cystic fibrosis was commenced an antibiotic regimen containing tigecycline with the diagnosis of acute bronchitis. On the 12th day of the treatment, severe epigastric abdominal pain and nausea appeared, and pancreatic enzyme levels increased 10 times more than normal. After eliminating other causes of pancreatitis, tigecycline treatment was discontinued, and the patient's clinical condition improved and laboratory findings returned to normal gradually. Clinicians should be careful when using tigecycline, especially in patients with high risk of developing pancreatitis, such as cystic fibrosis.

Anahtar Kelimeler

• Tigecycline,
• acute pancreatitis,
• cystic fibrosis,

Kistik fibrozis tanılı erişkinde muhtemel tigesiklin ilişkili akut pankreatit

Öz

Bu vaka sunumunun amacı, özellikle yüksek riskli hastalarda tigesikline bağlı pankreatit farkındalığının artırılmasıdır. 19 yaşında bilinen kistik fibrozis tanılı erkek hastaya akut bronşit nedeniyle tigesiklin içeren antibiyotik tedavisi başlandı. Tedavinin 12. gününde hastada şiddetli epigastrik karın ağrısı ve bulantı şikayetleri ortaya çıktı ve pankreatik enzim düzeylerinde normalin 10 katına kadar artış görüldü. Diğer akut pankreatit nedenleri ekarte edildikten sonra tigesiklin tedavisi kesildi. Takiplerinde hastanın klinik semptom ve bulguları giderek geriledi ve laboratuvar değerleri normale döndü. Klinisyenler özellikle kistik fibrozis gibi pankreatit gelişim riski yüksek olan hastalarda tigesiklin kullanırken dikkatli olmalıdırlar.

Anahtar Kelimeler

• Tigesiklin,
• akut pankreatit,

Kaynakça

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