Alkolün Karaciğer Görünür Difüzyon Katsayısı Değerleri Üzerine Etkileri: Tek Merkez Çalışması

Öz

Giriş ve Amaç: Bu çalışmada aşırı alkol tüketimi öyküsü olan bireyler ve sağlıklı gönüllüler arasında karaciğer diffüzyon ağırlıklı manyetik rezonans görüntüleme ile elde edilen görünür diffüzyon katsayısı değerlerini karşılaştırarak, karaciğer görünür diffüzyon katsayısı değerleri ile potansiyel erken evre karaciğer hasarı arasındaki ilişkiyi araştırmak amaçlanmıştır. Gereç ve Yöntem: Aşırı alkol tüketimi öyküsü olan 35 kişi ve 32 sağlıklı gönüllü bu çalışma için planlanmıştır. Tüm olgularda biyokimyasal parametreleri ölçmek ve tam kan sayımı için kan örnekleri alınmış olup, karaciğer diffüzyon ağırlıklı görüntülemeyi içeren üst abdominal manyetik rezonans görüntüleme yapılmıştır. Bulgular: Aşırı alkol tüketimi öyküsü olan 19 birey ve 20 sağlıklı gönüllü çalışmaya dahil edilmiştir. Aşırı alkol tüketimi öyküsü olan bireylerde yüksek b değeri (b 1000) diffüzyon ağırlıklı görüntülemeyle elde edilen ortalama görünür diffüzyon katsayısı değerleri, sağlıklı gönüllülerden daha düşük bulunmuştur. Her iki grup arasında biyokimyasal parametreler açısından anlamlı bir fark gözlenmese de, her iki gruptaki karaciğer görünür diffüzyon katsayısı değerleri uluslararası normalizasyon oranı değerleri ile pozitif, gama-glutamil transferaz ve alkalen fosfataz değerleri ile negatif korelasyon göstermiştir (sırasıyla r = 0.002, r = -0.007, r = -0.049). Sonuç: Diffüzyon ağırlıklı görüntüleme, alkol tüketiminin neden olduğu karaciğer fibrozisinin saptanması ve takibi için kullanılabilecek noninvaziv bir görüntüleme tekniğidir.

Anahtar Kelimeler

• Alkol
• karaciğer
• diffüzyon ağırlıklı manyetik rezonans görüntüleme

Effects of Alcohol on Liver Apparent Diffusion Coefficient values: A Single Center Study

Öz

Background and Aims: This study aimed to investigate the relationship between liver apparent diffusion coefficient values and potential early-stage liver injury by comparing apparent diffusion coefficient values obtained by liver diffusion-weighted magnetic resonance imaging between individuals with a history of excessive alcohol consumption and healthy volunteers. Materials and Methods: This study enrolled 35 individuals with a history of excessive alcohol consumption and 32 healthy volunteers. In all cases, blood samples were taken to measure biochemical parameters and complete blood count. Upper abdominal magnetic resonance imaging including liver diffusion-weighted imaging was performed. Results: In total, 19 individuals with a history of excessive alcohol consumption and 20 healthy volunteers were included in the study. The mean apparent diffusion coefficient values obtained by high b value (b 1000) diffusion-weighted imaging in individuals with a history of excessive alcohol consumption were lower than those in healthy volunteers. Although no significant difference was observed between the two groups in terms of biochemical parameters, hepatic apparent diffusion coefficient values in both groups were positively correlated with international normalized ratio values and negatively correlated with gamma-glutamyl transferase and alkaline phosphatase levels (r = 0.002, r = −0.007, r = −0.049, respectively). Conclusion: Diffusion-weighted imaging is a noninvasive imaging technique that can be used for the detection and follow-up of liver fibrosis induced by alcohol consumption.

Anahtar Kelimeler

• Alcohol
• liver
• diffusion-weighted magnetic resonance imaging

Kaynakça

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