Sitoredüktif cerrahi ve CC/0 rezeksiyonla hipertermik intraperitoneal kemoterapi uygulanan hastalarda distal pankreatektomi ve splenektominin sonuçlara etkisi

Öz

Giriş ve Amaç: Bu çalışmanın amacı, peritoneal karsinomatozis nedeniyle sitoredüktif cerrahi ve hipertermik intraperitoneal kemoterapi uygulanan ve komplet sitoredüksiyon sağlanan hastalarda distal pankreatektomi+splenektominin erken ve geç postoperatif etkilerini belirlemektir. Gereç ve Yöntem: Kliniğimizde 2014-2020 yılları arasında çeşitli tümörlerin peritoneal karsinomatozisi nedeniyle sitoredüktif cerrahi ve hipertermik intraperitoneal kemoterapi işlemi yapılan tüm hastalar çalışmaya dahil edildi. Ek distal pankreatektomi ve splenektomi yapılan tüm hastaların verileri retrospektif olarak analiz edildi. Bulgular: Peritoneal karsinomatozis tanısıyla ameliyat edilen 136 hastanın 85'ine (komplet sitoredüksiyon rezeksiyonla) sitoredüktif cerrahi ve hipertermik intraperitoneal kemoterapi işlemi uygulandı. Bu hastaların 13’ünün (%15.3) ana işlemle birlikte distal pankreatektomi + splenektomi geçirdiği değerlendirildi. Distal pankreatektomi ve splenektomi yapılan hastalarda ortalama yatış süresi 15 (5-50) gün iken, yapılmayanlarda 13 (4-109) gündü ve aradaki fark istatistiksel olarak anlamsızdı. Distal pankreatektomi ve splenektomi yapılan grupta en sık görülen majör komplikasyon anastomoz kaçağı, enterokutanöz fistül ve intraabdominal apse idi. 30 günlük mortalite distal pankreatektomi ve splenektomi eklenen ve eklenmeyen gruplarda sırası ile 2 (%15.38) ve 1 (%1.38) idi. Gruplar değerlendirildiğinde; medyan sağkalım süresi sitoredüktif cerrahi ve hipertermik intraperitoneal kemoterapi grubunda 19 ay, sitoredüktif cerrahi ve hipertermik intraperitoneal kemoterapi + distal pankreatektomi ve splenektomili grupta 18 aydı ve istatistiksel olarak anlamlı değildi (p = 0.382). Sonuç: Distal pankreatektomi ve splenektomi eklenmesi, sitoredüktif cerrahi ve hipertermik intraperitoneal kemoterapi uygulanan hastalarda postoperatif majör komplikasyonları arttırmaktadır, fakat genel ortalama sağkalımı etkilememiştir. Tam bir sitoredüksiyon için gerekirse distal pankreatektomi ve splenektomi yapılabileceğini düşünüyoruz ancak bu işlemin postoperatif majör komplikasyonların gelişimini arttırdığı bilinmeli ve buna göre hasta takibi yapılmalıdır.

Anahtar Kelimeler

• Hipertermik intraperitoneal kemoterapi
• sitoredüktif cerrahi
• distal pankreatektomi
• splenektomi

Effects of distal pancreatectomy and splenectomy on outcomes in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with CC/0 resection

Öz

Background and Aim: This study aims to determine the early and late postoperative effects of distal pancreatectomy plus splenectomy in patients who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and achieved CC0 resection due to peritoneal carcinomatosis. Material and Method: All patients who underwent a cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedure due to peritoneal carcinomatosis of various tumors in our clinic between 2014 and 2020 were included in the study. Data from all patients who underwent additional distal pancreatectomy plus splenectomy were analyzed retrospectively. Results: The cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedure with CC/0 resection was performed on 85 of 136 patients diagnosed with peritoneal carcinomatosis. Of these patients, 13 (15.3%) had undergone distal pancreatectomy plus splenectomy together with the main procedure. The mean hospital stay was 15 (range, 5–50) days in patients who underwent distal pancreatectomy plus splenectomy, whereas it was 13 (range, 4–109) days in those who did not, and the difference was statistically insignificant. The most common major complications seen in the distal pancreatectomy plus splenectomy group were an anastomotic leak, enterocutaneous fistula, and intraabdominal abscess. The 30-day mortality was two (15.38%) and one (1.38%) in the group with and the group without distal pancreatectomy plus splenectomy, respectively. When the groups were evaluated, the median survival time was 19 months in the cytoreductive surgery and hyperthermic intraperitoneal chemotherapy group and 18 months in the cytoreductive surgery and hyperthermic intraperitoneal chemotherapy + distal pancreatectomy plus splenectomy group. This difference was statistically insignificant (p = 0.382). Conclusion: The addition of distal pancreatectomy plus splenectomy increased major postoperative complications in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy but did not affect overall survival. We think distal pancreatectomy plus splenectomy can be performed for a complete cytoreduction if necessary. However, it increases major postoperative complications, and patient follow-up should be done accordingly.

Anahtar Kelimeler

• Hyperthermic intraperitoneal chemotherapy
• cytoreductive surgery
• distal pancreatectomy
• splenectomy

Kaynakça

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