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RESVERATROL IN WINES: THE EFFECTS ON CORONORY HEART DISEASES AND CANCER

Yıl 2006, Cilt: 4 Sayı: 3, 12 - 14, 01.06.2006

Öz

Resveratrol is a non-flavonoid polyphenol that has attracted attention as a potential anti-cancer agent. On the other hand, it is expressed that coronory heart diseases are prevented by resveratrol. It has been related with resveratrol the benefits of drinking red wine 1or 2 glasses in a day. An inverse correlation between consumption of red wine and incidence of cardiovascular diseases led to the concept of the “French paradox”

Kaynakça

  • Nonomura, S., Kanagawa, H. & Makimoto, A. 1963. Chemical
  • constituents of polygonaceus plants. Studies on the components of Ko-jokan
  • (Polyganum Cuspidatum SIEB et zucc). Yakugaku Zasshi, 83:983-988. 25. Aktan, N. 2000. Bir yudum şarap. Doğa Ofset, 48 sayfa. 26. Bisson, L. F., Butzke, C. E. & Ebeler, S. E. 1995. The role of moderate ethanol consumption in health and human nutrition. American Journal of Tissue Reaction, 17, 1-3.
  • A comparison of four red wine polyphenols. Clinical biochemistry, 35, 119- 124. 27. Blond, J., Denis, M. & Bezard, J. 1995. Antioxidant action of resveratrol in lipid peroxidation. Sciences des Aliments, 15, 347-358.
  • Langcake, P. & Pryce, R. J. 1976. The production of resveratrol by Vitis
  • vinifera and other members of the Vita ceae as a response to infection or injury.
  • Physiol plant., Pathol. 9:77-86. 28. Demrow, H. S., Slane, P. R. & Flots, J. D. 1995. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronory arteries, Circulation, 91, 1182-1188.
  • Siemann, H.E. & Creasy. L. L. 1992. Concentration of the phytoalexin
  • resveratrol in wine. American Journal of Enology and Viticulture, 43, 49-52. 29. Fittzpatrick, D. E., Hirschfield, S. L. & Coffey, R. G. 1993. Endothelium- dependent vasorelex-ing activity of wine, grapes and other plant products. American Journal of Physiology, 265, H774-H778.
  • Improvement on enzymatic hydrolysis of resveratrol glucosides in wine.
  • Food Chem., 42; 2077-2083. 30. Frankel, E. N., Kanner, J., German, J. B., Parks, E. & Kinsella, J. E. 1993. Inhibition of oxidation of human low density lipoprotein by phenolic substances in red wine, Lancet. 341:454-457.
  • Goldberg, D. M., Yan, J., Ng. E., Diamandis, E. P., Karumanchiri, A.
  • Soleas, G. & Waterhouse, A. L. 1995. A global survey of trans-resveratrol
  • concentrations im commercial wines. American Journal of Enology and Viticulture, 46, 159-165. 31. Fuhrman, B., Lavy, A. & Aviram, M. 1995. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein peroxidation. American Journal of Clinical Nutrition, 61, 549-554.
  • Soleas, G. J., Diamandis, E.P. & Goldberg. D. M. 1997. Clinical
  • biochemistry, 30:91-113. 32. Rimm, E. B., Giovannocci, E.L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B. & Stampfer, M. J. 1991. Prospective study of alcohol consuption and risk of coronary disease in men. Lancet, 338, 464-468.
  • Lopez-Velez, M., Martinez-Martinez, F. & Del Valle-Ribes, C. 2003. The
  • study of phenolic compounds as natural antioxidants in wine. Critical Reviews in
  • Food Science and Nutrition, 43(3): 233-244. 33. Seigneur, M., Bonnet, J., Dorian, B., Benchimol, D., Drouillet, F., Gouverneur, G., Larrue, J., Crockett, R., Boisseau, M., Ribereau-Gayon, P. & Bricaud, H. 1990. Effect of the consumption of alcohol, white wine and red wine on platelet function and serum lipids. Journal of applied and Viticulture, 43, 49-52.
  • De Santi, C., Pietrabissa, A., Spisni, R., Mosca, F. & Pacifici, G. M.
  • Sulphation of resveratrol a natural compoundpresent in wine and its
  • inhibition by natural favonoids. Xenobiotica, Vol: 30. No: 9, 857-866. 34. Ferraroni, M., Decarli., Franceschi, S. 1996. Validity and reproducibility of alcohol consumption in Italy. Int. J. Epidemiol., 25:775-82.
  • Vrhovsek, U., Wendelin, S. & Eder, R. 1997. Effects of various vinification
  • techniques on the concentration of cis- and trans resveratrol and resveratrol
  • glucoside isomers in wine. American Journal of Enology and Viticulture, 48, 214 219. 35. St Leger, A. S., Cochrana, A. L. & Moore, F. 1979. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet., 1017-1020. 36. Bertelli, A. A., Giovannini, l., Gianessi , D., Migliori, M., Bernini. W., Fregoni, M. & Bertelli, A. 1995. Antiplatelet activity of synthetic and natural rsveratrol in red wine. International Journal of Enology and Viticulture, 38, 65-68.
  • determination of cis and trans-resveratrol in wines by capillary zone
  • electrophoresis. Analyst., 124, 61-66. 37. Hertog, M. G. L., Hollman, P.C.H. & Katan, M. B. 1992. Content of potentially anticarcinogenic flavonoids of 28 vegetables and nine fruits commonly consumed in the Netherlands. J. Agric.Food Chem., 40: 2379-83.
  • isomers in commercially available wines made from grapes cultivated in Japan.
  • Bioscience Biotechnology and Bichemistry, 61, 1800-1805. 38. Hollman, P. C. & Katan, M. B. 1997. Absorbtion, metabolism and health effects of dietary flavonoids. in. Man. Biomed Pharmacother, 51:305-10.
  • compounds from the grape wine to wine.. Drugs under Experimental and Clinical
  • Research, 25, 57-63. 39. Landofi, R., Moer, R. & Steiner, M. 1984. Modification of platelet function and arachidonic acid metabolism by flavonoids. Biochemistry Pharmacology, 33:1525-1530.
  • sefence mechanisms. Tansley Review. No.72, New Phytologist., 127, 617-633.
  • Fremont, L. 1999. Biological effects of resveratrol. Life Sciences, Vol.66, No.8, 663-673. 40. Subbarrmaiah, K., Chung, W. J., Michaluart, P., Telang, N., Tanabe, T. & Inoue, H. 1998. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem., 273: 21875-82.
  • Yücel, U. 2000. Geleneksel şarap üretiminde ekolojik yaklaşımlar. Dünya Gıda Ocak, 54-55. 41. Maccarrone, M., Lorenzon, T. & Guerrieri, P. 1999. Resveratrol prevents apontosis in K562 cells by inhibiting lipoxygenase activity. Eur. J. Biochem., 265: 27-34.
  • wine by capillary electrophoresis. Journal of Chromatography A, 881, 471-481.
  • Romero- Perez, A. I., Lamuela- Raventos, R. M., C, Andres Lacueva
  • C. & de La Torre- Boronat, M. C. 2001. Method for the quantitative extraction
  • of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on
  • Chemistry, 76, 371-375
  • Tinttunen, S. & Lehtonen, P. 2001. Distinguishing organic wines from
  • normal wines on the basis of concentrations of phenolic compounds and spectral
  • data. Eur Food Res. Technol., 212;390-394
  • Savouret, J.F & Quesne. M. 2002. Resvereatrol and Cancer: A review.
  • Biomed Pharma cother, 56: 84-87.

Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri

Yıl 2006, Cilt: 4 Sayı: 3, 12 - 14, 01.06.2006

Öz

Resveratrol flavonoid olmayan bir polifenol olup, potansiyel bir antikanserojen bileşik olarak değerlendirilmekte bunun yanı sıra söz konusu bileşiğin koroner kalp hastalıklarını önlemede etkili olduğu ifade edilmektedir. Günde 1-2 kadeh kırmızı şarap tüketiminin yararları bu bileşikle ilişkilendirilmiştir. Kırmızı şarap tüketimi ile kardiovasküler hastalıkların oluşumu arasındaki ters orantı Fransız paradoksu olarak tanımlanmaktadır

Kaynakça

  • Nonomura, S., Kanagawa, H. & Makimoto, A. 1963. Chemical
  • constituents of polygonaceus plants. Studies on the components of Ko-jokan
  • (Polyganum Cuspidatum SIEB et zucc). Yakugaku Zasshi, 83:983-988. 25. Aktan, N. 2000. Bir yudum şarap. Doğa Ofset, 48 sayfa. 26. Bisson, L. F., Butzke, C. E. & Ebeler, S. E. 1995. The role of moderate ethanol consumption in health and human nutrition. American Journal of Tissue Reaction, 17, 1-3.
  • A comparison of four red wine polyphenols. Clinical biochemistry, 35, 119- 124. 27. Blond, J., Denis, M. & Bezard, J. 1995. Antioxidant action of resveratrol in lipid peroxidation. Sciences des Aliments, 15, 347-358.
  • Langcake, P. & Pryce, R. J. 1976. The production of resveratrol by Vitis
  • vinifera and other members of the Vita ceae as a response to infection or injury.
  • Physiol plant., Pathol. 9:77-86. 28. Demrow, H. S., Slane, P. R. & Flots, J. D. 1995. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronory arteries, Circulation, 91, 1182-1188.
  • Siemann, H.E. & Creasy. L. L. 1992. Concentration of the phytoalexin
  • resveratrol in wine. American Journal of Enology and Viticulture, 43, 49-52. 29. Fittzpatrick, D. E., Hirschfield, S. L. & Coffey, R. G. 1993. Endothelium- dependent vasorelex-ing activity of wine, grapes and other plant products. American Journal of Physiology, 265, H774-H778.
  • Improvement on enzymatic hydrolysis of resveratrol glucosides in wine.
  • Food Chem., 42; 2077-2083. 30. Frankel, E. N., Kanner, J., German, J. B., Parks, E. & Kinsella, J. E. 1993. Inhibition of oxidation of human low density lipoprotein by phenolic substances in red wine, Lancet. 341:454-457.
  • Goldberg, D. M., Yan, J., Ng. E., Diamandis, E. P., Karumanchiri, A.
  • Soleas, G. & Waterhouse, A. L. 1995. A global survey of trans-resveratrol
  • concentrations im commercial wines. American Journal of Enology and Viticulture, 46, 159-165. 31. Fuhrman, B., Lavy, A. & Aviram, M. 1995. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein peroxidation. American Journal of Clinical Nutrition, 61, 549-554.
  • Soleas, G. J., Diamandis, E.P. & Goldberg. D. M. 1997. Clinical
  • biochemistry, 30:91-113. 32. Rimm, E. B., Giovannocci, E.L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B. & Stampfer, M. J. 1991. Prospective study of alcohol consuption and risk of coronary disease in men. Lancet, 338, 464-468.
  • Lopez-Velez, M., Martinez-Martinez, F. & Del Valle-Ribes, C. 2003. The
  • study of phenolic compounds as natural antioxidants in wine. Critical Reviews in
  • Food Science and Nutrition, 43(3): 233-244. 33. Seigneur, M., Bonnet, J., Dorian, B., Benchimol, D., Drouillet, F., Gouverneur, G., Larrue, J., Crockett, R., Boisseau, M., Ribereau-Gayon, P. & Bricaud, H. 1990. Effect of the consumption of alcohol, white wine and red wine on platelet function and serum lipids. Journal of applied and Viticulture, 43, 49-52.
  • De Santi, C., Pietrabissa, A., Spisni, R., Mosca, F. & Pacifici, G. M.
  • Sulphation of resveratrol a natural compoundpresent in wine and its
  • inhibition by natural favonoids. Xenobiotica, Vol: 30. No: 9, 857-866. 34. Ferraroni, M., Decarli., Franceschi, S. 1996. Validity and reproducibility of alcohol consumption in Italy. Int. J. Epidemiol., 25:775-82.
  • Vrhovsek, U., Wendelin, S. & Eder, R. 1997. Effects of various vinification
  • techniques on the concentration of cis- and trans resveratrol and resveratrol
  • glucoside isomers in wine. American Journal of Enology and Viticulture, 48, 214 219. 35. St Leger, A. S., Cochrana, A. L. & Moore, F. 1979. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet., 1017-1020. 36. Bertelli, A. A., Giovannini, l., Gianessi , D., Migliori, M., Bernini. W., Fregoni, M. & Bertelli, A. 1995. Antiplatelet activity of synthetic and natural rsveratrol in red wine. International Journal of Enology and Viticulture, 38, 65-68.
  • determination of cis and trans-resveratrol in wines by capillary zone
  • electrophoresis. Analyst., 124, 61-66. 37. Hertog, M. G. L., Hollman, P.C.H. & Katan, M. B. 1992. Content of potentially anticarcinogenic flavonoids of 28 vegetables and nine fruits commonly consumed in the Netherlands. J. Agric.Food Chem., 40: 2379-83.
  • isomers in commercially available wines made from grapes cultivated in Japan.
  • Bioscience Biotechnology and Bichemistry, 61, 1800-1805. 38. Hollman, P. C. & Katan, M. B. 1997. Absorbtion, metabolism and health effects of dietary flavonoids. in. Man. Biomed Pharmacother, 51:305-10.
  • compounds from the grape wine to wine.. Drugs under Experimental and Clinical
  • Research, 25, 57-63. 39. Landofi, R., Moer, R. & Steiner, M. 1984. Modification of platelet function and arachidonic acid metabolism by flavonoids. Biochemistry Pharmacology, 33:1525-1530.
  • sefence mechanisms. Tansley Review. No.72, New Phytologist., 127, 617-633.
  • Fremont, L. 1999. Biological effects of resveratrol. Life Sciences, Vol.66, No.8, 663-673. 40. Subbarrmaiah, K., Chung, W. J., Michaluart, P., Telang, N., Tanabe, T. & Inoue, H. 1998. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem., 273: 21875-82.
  • Yücel, U. 2000. Geleneksel şarap üretiminde ekolojik yaklaşımlar. Dünya Gıda Ocak, 54-55. 41. Maccarrone, M., Lorenzon, T. & Guerrieri, P. 1999. Resveratrol prevents apontosis in K562 cells by inhibiting lipoxygenase activity. Eur. J. Biochem., 265: 27-34.
  • wine by capillary electrophoresis. Journal of Chromatography A, 881, 471-481.
  • Romero- Perez, A. I., Lamuela- Raventos, R. M., C, Andres Lacueva
  • C. & de La Torre- Boronat, M. C. 2001. Method for the quantitative extraction
  • of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on
  • Chemistry, 76, 371-375
  • Tinttunen, S. & Lehtonen, P. 2001. Distinguishing organic wines from
  • normal wines on the basis of concentrations of phenolic compounds and spectral
  • data. Eur Food Res. Technol., 212;390-394
  • Savouret, J.F & Quesne. M. 2002. Resvereatrol and Cancer: A review.
  • Biomed Pharma cother, 56: 84-87.
Toplam 44 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Research Article
Yazarlar

Ufuk Yücel Bu kişi benim

Eren Akçiçek Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2006
Yayımlandığı Sayı Yıl 2006 Cilt: 4 Sayı: 3

Kaynak Göster

APA Yücel, U., & Akçiçek, E. (2006). Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda, 4(3), 12-14.
AMA Yücel U, Akçiçek E. Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda. Haziran 2006;4(3):12-14.
Chicago Yücel, Ufuk, ve Eren Akçiçek. “Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları Ve Kanser Üzerine Etkileri”. Akademik Gıda 4, sy. 3 (Haziran 2006): 12-14.
EndNote Yücel U, Akçiçek E (01 Haziran 2006) Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda 4 3 12–14.
IEEE U. Yücel ve E. Akçiçek, “Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri”, Akademik Gıda, c. 4, sy. 3, ss. 12–14, 2006.
ISNAD Yücel, Ufuk - Akçiçek, Eren. “Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları Ve Kanser Üzerine Etkileri”. Akademik Gıda 4/3 (Haziran 2006), 12-14.
JAMA Yücel U, Akçiçek E. Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda. 2006;4:12–14.
MLA Yücel, Ufuk ve Eren Akçiçek. “Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları Ve Kanser Üzerine Etkileri”. Akademik Gıda, c. 4, sy. 3, 2006, ss. 12-14.
Vancouver Yücel U, Akçiçek E. Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda. 2006;4(3):12-4.

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