Yıl 2021, Cilt 19 , Sayı 1, Sayfalar 89 - 97 2021-04-26

Propolis and Effects on Human Health
Propolis ve Sağlık Üzerine Etkileri

Aylin SEYLAM KÜŞÜMLER [1] , Ayça ÇELEBİ [2]


Propolis is a natural product collected by honeybees from plants, especially their flowers and buds, by mixing with wax and resin, and used for various purposes in hive. Several scientific studies have shown that propolis can be used to treat various diseases in conventional medicine since ancient times and has biological activities such as antioxidant, antimicrobial, antitumor, anti-inflammatory. Studies in the last five years have shown that phenolic compounds especially caffeic acid esters (CAPE) in propolis have high antioxidant and anti-inflammatory activity levels. Especially, some studies have demonstrated that CAPE may inhibit oxidative stress mechanisms and supress cytokine production. To ensure its effectiveness on human immune system, even though its effective intake dose is not clear, its reliable dose is 70 mg/kg, and any intake above 15 g is regarded as a toxic dose. Studies on propolis and its efficacy, side effects and reliable dose are increasing day by day, especially its effect on human immune system. In future studies, the mechanisms of its activity on immune system and more information on its effective doses are going to be significant at the level of evidence. Accordingly, it is important to define the effects of propolis on human immune system and overall health. In this study, it is aimed to summarize the studies on the properties of propolis, its consumption dose and its effects on human health.
Propolis, bal arıları tarafından bitkilerden özellikle de çiçek ve tomurcuklardan toplanan belirli miktarda balmumu ve reçine karışımı ve esansiyel yağları içeren ve kovan içerisinde birçok amaca uygun olarak kullanılan doğal bir arı ürünüdür. İnsan sağlığı üzerinde yapılan çalışmalarda antioksidan, anti-mikrobiyal, anti-tümor, anti- inflamatuvar başta olmak üzere birçok biyolojik aktiviteye sahiptir. Son beş yıla dönük çalışmalara bakıldığında, propolis ve yapısında bulunan kafeik asit bileşeninin antioksidan ve antiinflamatuvar etkiye sahip olduğu, bağışıklık sistemi ve diğer sağlık durumları üzerine etki gösterdiği gözlenmiştir. Özellikle stres ve inflamatuvar sitokin artışının olduğu mekanizmalarda kafeik asit bileşeninin mekanizmadaki etkin enzimlerin inhibisyonunu sağladığı gözlenmiştir. Bağışıklık sistemi üzerine etkili olabilmesi için alınması gereken doz konusunda tam netlik olmasa bile yapılan randomize kontrollü çalışmalar sonucunda belirlenen günlük alımda güvenilir olan doz 70 mg/kg olup, 15 g üstü alım toksik doz olarak belirlenmiştir. Propolisin bağışıklık sistemi üzerine etkisi, yan etkileri ve güvenilir dozu ile ilgili çalışmalar gün geçtikçe artmaktadır. Önümüzdeki dönemlerde yapılan çalışmalarla birlikte bağışıklık sistemi üzerindeki etkinlik mekanizmaları ve doz konusundaki bilgiler kanıt düzeyinde anlamlılık kazanacaktır. Buna bağlı olarak propolisin başta bağışıklık sistemi ve bütüncül olarak insan sağlığına etkilerinin tanımlanması önemlidir. Bu çalışmanın amacı; propolisin özellikleri, tüketim dozu ve insan sağlığı üzerine etkileri konusunda yapılan çalışmaların özetlenerek, aktarılmasıdır.
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Birincil Dil tr
Konular Gıda Bilimi ve Teknolojisi
Bölüm Derleme Makaleler
Yazarlar

Orcid: 0000-0003-4705-8042
Yazar: Aylin SEYLAM KÜŞÜMLER
Kurum: İstanbul Okan Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
Ülke: Turkey


Orcid: 0000-0001-9955-6997
Yazar: Ayça ÇELEBİ (Sorumlu Yazar)
Kurum: İstanbul Okan Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 26 Nisan 2021

Bibtex @derleme { akademik-gida927709, journal = {Akademik Gıda}, issn = {1304-7582}, eissn = {2148-015X}, address = {Fevzipaşa Bulv. Çelik İş Merkezi, No: 162, Kat: 3, D:302, Çankaya, İzmir}, publisher = {Sidas Medya A.Ş.}, year = {2021}, volume = {19}, pages = {89 - 97}, doi = {10.24323/akademik-gida.927709}, title = {Propolis ve Sağlık Üzerine Etkileri}, key = {cite}, author = {Seylam Küşümler, Aylin and Çelebi, Ayça} }
APA Seylam Küşümler, A , Çelebi, A . (2021). Propolis ve Sağlık Üzerine Etkileri . Akademik Gıda , 19 (1) , 89-97 . DOI: 10.24323/akademik-gida.927709
MLA Seylam Küşümler, A , Çelebi, A . "Propolis ve Sağlık Üzerine Etkileri" . Akademik Gıda 19 (2021 ): 89-97 <https://dergipark.org.tr/tr/pub/akademik-gida/issue/62016/927709>
Chicago Seylam Küşümler, A , Çelebi, A . "Propolis ve Sağlık Üzerine Etkileri". Akademik Gıda 19 (2021 ): 89-97
RIS TY - JOUR T1 - Propolis ve Sağlık Üzerine Etkileri AU - Aylin Seylam Küşümler , Ayça Çelebi Y1 - 2021 PY - 2021 N1 - doi: 10.24323/akademik-gida.927709 DO - 10.24323/akademik-gida.927709 T2 - Akademik Gıda JF - Journal JO - JOR SP - 89 EP - 97 VL - 19 IS - 1 SN - 1304-7582-2148-015X M3 - doi: 10.24323/akademik-gida.927709 UR - https://doi.org/10.24323/akademik-gida.927709 Y2 - 2021 ER -
EndNote %0 Akademik Gıda Propolis ve Sağlık Üzerine Etkileri %A Aylin Seylam Küşümler , Ayça Çelebi %T Propolis ve Sağlık Üzerine Etkileri %D 2021 %J Akademik Gıda %P 1304-7582-2148-015X %V 19 %N 1 %R doi: 10.24323/akademik-gida.927709 %U 10.24323/akademik-gida.927709
ISNAD Seylam Küşümler, Aylin , Çelebi, Ayça . "Propolis ve Sağlık Üzerine Etkileri". Akademik Gıda 19 / 1 (Nisan 2021): 89-97 . https://doi.org/10.24323/akademik-gida.927709
AMA Seylam Küşümler A , Çelebi A . Propolis ve Sağlık Üzerine Etkileri. Akademik Gıda. 2021; 19(1): 89-97.
Vancouver Seylam Küşümler A , Çelebi A . Propolis ve Sağlık Üzerine Etkileri. Akademik Gıda. 2021; 19(1): 89-97.
IEEE A. Seylam Küşümler ve A. Çelebi , "Propolis ve Sağlık Üzerine Etkileri", Akademik Gıda, c. 19, sayı. 1, ss. 89-97, Nis. 2021, doi:10.24323/akademik-gida.927709