Derleme
BibTex RIS Kaynak Göster

Propolis ve Sağlık Üzerine Etkileri

Yıl 2021, Cilt: 19 Sayı: 1, 89 - 97, 26.04.2021
https://doi.org/10.24323/akademik-gida.927709

Öz

Propolis, bal arıları tarafından bitkilerden özellikle de çiçek ve tomurcuklardan toplanan belirli miktarda balmumu ve reçine karışımı ve esansiyel yağları içeren ve kovan içerisinde birçok amaca uygun olarak kullanılan doğal bir arı ürünüdür. İnsan sağlığı üzerinde yapılan çalışmalarda antioksidan, anti-mikrobiyal, anti-tümor, anti- inflamatuvar başta olmak üzere birçok biyolojik aktiviteye sahiptir. Son beş yıla dönük çalışmalara bakıldığında, propolis ve yapısında bulunan kafeik asit bileşeninin antioksidan ve antiinflamatuvar etkiye sahip olduğu, bağışıklık sistemi ve diğer sağlık durumları üzerine etki gösterdiği gözlenmiştir. Özellikle stres ve inflamatuvar sitokin artışının olduğu mekanizmalarda kafeik asit bileşeninin mekanizmadaki etkin enzimlerin inhibisyonunu sağladığı gözlenmiştir. Bağışıklık sistemi üzerine etkili olabilmesi için alınması gereken doz konusunda tam netlik olmasa bile yapılan randomize kontrollü çalışmalar sonucunda belirlenen günlük alımda güvenilir olan doz 70 mg/kg olup, 15 g üstü alım toksik doz olarak belirlenmiştir. Propolisin bağışıklık sistemi üzerine etkisi, yan etkileri ve güvenilir dozu ile ilgili çalışmalar gün geçtikçe artmaktadır. Önümüzdeki dönemlerde yapılan çalışmalarla birlikte bağışıklık sistemi üzerindeki etkinlik mekanizmaları ve doz konusundaki bilgiler kanıt düzeyinde anlamlılık kazanacaktır. Buna bağlı olarak propolisin başta bağışıklık sistemi ve bütüncül olarak insan sağlığına etkilerinin tanımlanması önemlidir. Bu çalışmanın amacı; propolisin özellikleri, tüketim dozu ve insan sağlığı üzerine etkileri konusunda yapılan çalışmaların özetlenerek, aktarılmasıdır.

Kaynakça

  • [1] Al-Hariri, M.T. (2011). Propolis and its direct and indirect hypoglycemic effect. Journal Family Community Medicine, 18(3), 152-154.
  • [2] Anjum, S.I., Ullah, A., Khan, K.A., Attaullah, M., Khan, H., Ali, H., Bashir, M.A., Tahir, M., Ansari, M.J., Ghramh, H.A., Adgaba, N., Dash, C.K. (2019). Composition and functional properties of propolis (bee glue): A review. Saudi Journal of Biological Sciences, 26(1), 1695-1703.
  • [3] Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., Pérez-Alvarez J.A. (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Sciences, 73(9), 117-124.
  • [4] Gómez-Caravaca, A., Gómez-Romero, M., Arráez-Román, D., Segura-Carretero, A., Fernández-Gutiérrez, A. (2006). Advances in the analysis of phenolic compounds in products derived from bees. Journal of Pharmaceutical and Biomedical Analysis, 41(4), 1220-1234.
  • [5] Huang, S., Zhang, C.-P., Wang, K., Li, G.Q., Hu, F.L. (2014). Recent advances in the chemical composition of propolis. Molecules, 19(12), 19610-19632.
  • [6] Li, A., Xuan, H., Sun, A., Liu, R., Cui, J. (2016). Preparative separation of polyphenols from water-soluble fraction of Chinese propolis using macroporous absorptive resin coupled with preparative high performance liquid chromatography. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1012-1013, 42-49.
  • [7] Türkiye Arı Yetişticileri Merkez Birliği (TAB). (2020). http://www.tab.org.tr/propolis Erişim tarihi: 24.04.2020.
  • [8] Olszewska, M. (2003). Flavonoids and their use in therapy. Farmacja Polska, 59(1), 391-402.
  • [9] Doğan, N., Hayoğlu, İ. (2012). Propolis ve kullanım alanları. Harran Üniversitesi Ziraat Fakültesi Dergisi. 16(3), 39-48.
  • [10] Park, Y.K., Alencar, S.M., Aguiar, C.L. (2002). Botanical origin and chemical composition of Brazilian propolis. Journal of Agricultural and Food Chemistry, 50(9), 2502-2506.
  • [11] Lotfy, M. (2006). Biological activity of bee propolis in health and disease. Asian Pacific Journal of Cancer Prevention, 7(1), 22-31.
  • [12] Cho, M.S., Park, W.S., Jung, W.K., Qian, Z.J., Lee, D.S., Choi, J.S., Lee, D.Y., Park, S.G., Seo, S.K., Kim, H.J., Won, J.Y., Yu, B.C., Choi, I.W. (2014). Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells. Pharmaceutical Biology, 52(7), 926-932.
  • [13] Anjaly, K., Tiku, A.B. (2018). Radio-Modulatory Potential of Caffeic Acid Phenethyl Ester: A Therapeutic Perspective. Anti-cancer Agents in Medicinal Chemistry, 18(4), 468-475.
  • [14] Volpi, N. (2004). Separation of flavonoids and phenolic acids from propolis by capillary zone electrophoresis. Electrophoresis, 25(12), 1872-1878.
  • [15] Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., Pérez-Alvarez, J.A. (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Science, 73(9), 117-124.
  • [16] Saad, M.A., Abdel Salam, R.M., Kenawy, S.A., Attia, A.S. (2015). Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion. Pharmacological Reports, 67(1), 115-122.
  • [17] Woo, K.J., Jeong, Y.J., Inoue, H., Park, J.W., Kwon, T.K. (2005). Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Letters, 579(3), 705-711.
  • [18] Choo, Y.K., Kang, H.Y., Lim, S.H. (2008). Cardiac problems in mad-honey intoxication. Circulation journal: Official Journal of the Japanese Circulation Society, 72(7), 1210-1211.
  • [19] Braakhuis, A. (2019). Evidence on the health benefits of supplemental propolis. Nutrients, 11(11), 2705.
  • [20] Matsui, T., Ebuchi, S., Fujise, T., Abesundara, K.J., Doi, S., Yamada, H., Matsumoto, K. (2004). Strong antihyperglycemic effects of watersoluble fraction of Brazilian propolis and its bioactive constituent, 3,4,5-triocaffeoylquinic acid. Biological and Pharmaceutical Bulletin, 27(11), 1797-1803.
  • [21] Afsharpour, F., Javadi, M., Hashemipour, S., Koushan, Y.,Haghighian, H.K. (2019). Propolis supplementation improves glycemic and antioxidant status in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study. Complementary Therapies in Medicine, 43, 283-288.
  • [22] Kang, L.J., Lee, H.B., Bae, H.J., Lee, S.G. (2010). Antidiabetic effect of propolis: reduction of expression of glucose-6-phosphatase through inhibition of Y279 and Y216 autophosphorylation of GSK-3α/β in HepG2 cells. Phytotherapy Research, 24(1),1554-1561.
  • [23] Okutan, H., Ozcelik, N., Yilmaz, H.R., Uz, E. (2005). Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart. Clinical Biochemistry, 38(2), 191-196.
  • [24] Lee K.W., Chun K.S., Lee J.S., Kang K.S., Surh Y.J., Lee H.J. (2004). Inhibition of cyclooxygenase‐2 expression and restoration of gap junction intercellular communication in H‐ras‐transformed rat liver epithelial cells by caffeic acid phenethyl ester. Annal of New York Academy Science, 1030, 501-507.
  • [25] Cho, M.J., Howard, L.R., Prior, R.L., Clark, J.R. (2004). Flavonoid glycosides and antioxidant capacity of varous blackberry, blueberry and red grape genotypes determined by high-performance liquid chromatography/mass spectrometry. Journal of the Science of Food and Agriculture, 84(13), 771-1782.
  • [26] Fuliang, H., Hepburn, H.R., Xuan, H., Chen, M., Daya, S., Radloff, S.E. (2005). Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacological Research, 51(2), 147-152.
  • [27] Kwon, Y.S., Park, D.H., Shin, E.J., Kwon, M.S., Ko, K.H., Kim, W.K., Jhoo, J.H., Jhoo, W.K., Wie, M.B., Jung, B.D., Kim, H.C. (2004). Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat. Neuroscience Letters, 355(3), 231-235.
  • [28] Meng, F., Liu, R., Gao, M., Wang, Y., Yu, X., Xuan, Z., Sun, J., Yang, F., Wu, C., Du, G. (2011). Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats. Brain Research, 1391, 93-101.
  • [29] Liu, R., Li, J.Z., Song, J.K., Zhou, D., Huang, C., Bai, X.Y., Xie, T., Zhang, X., Li, Y.J., Wu, C.X., Zhang, L., Li, L., Zhang, T.T., Du, G.H. (2014). Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits. Neurobiology of Aging, 35(6),1275-1285.
  • [30] Alkis, H.E., Kuzhan, A., Dirier, A.,Tarakcioglu, M., Demir, E., Saricicek, E.,Demir, T., Ahlatci,A., Demirci, A.,Cinar, K. (2015). Neuroprotective effects of propolis and caffeic acid phenethyl ester (CAPE) on the radiation-injured brain tissue. International Journal of Radiation Research, 13(4), 297-303.
  • [31] AL-Waili, N., Al Ghamdi, A., Ansari, M.J., Al-Attal, Y., Al-Mubarak, A., Salom, K. (2013). Differences in composition of honey samples and their impact on the antimicrobial activities against drug multiresistant bacteria and pathogenic fungi. Archives of Medical Research, 44(4), 307-316.
  • [32] Gao, W., Wu, J., Wei, J., Pu, L., Guo, C., Yang, J., Yang, M., Luo, H. (2014). Brazilian green propolis improves immune function in aged mice. Journal of Clinical Biochemistry and Nutrition, 55(1), 7-10.
  • [33] Nakajima, Y., Shimazawa, M., Mishima, S., Hara, H. (2009). Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis. Phytotherapy Research, 23(10), 1431-1438.
  • [34] Braakhuis A. (2019). Evidence on the health benefits of supplemental propolis. Nutrients, 11(11), 2705.
  • [35] Batista, L.L.V., Campesatto, E.A., Assis, M.L.B., Barbosa, A.P.F., Grillo, L.A.M., Dornelas, C.B. (2012). Comparative study of topical green and red propolis in the repair of wounds induced in rats. Journal of the Brazilian College of Surgeons, 39(6), 515-520.
  • [36] Baktır, G. (2011). Yara iyileşmesi ve deneysel yara modelleri. Experimed, 9(3), 130-137.
  • [37] Stewart, J.A., McGrane, O.L., Wedmore, I.S. (2014). Wound care in the wilderness: is there evidence for honey? Wilderness Environmental Medicine, 25(1), 103-110.
  • [38] Tolba, M.F., Azab, S.S., Khalifa, A. E., Abdel-Rahman, S.Z., Abdel-Naim, A.B. (2013). Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: a review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects. IUBMB Life, 65(8), 699-709.
  • [39] Swamy, M., Suhaili, D., Sirajudeen, K.N., Mustapha, Z., Govindasamy, C. (2014). Propolis ameliorates tumor nerosis factor-α, nitric oxide levels, caspase-3 and nitric oxide synthase activities in kainic acid mediated excitotoxicity in rat brain. African Journal of Traditional, Complementary, and Alternative Medicines, 11(5), 48-53.
  • [40] Alkhaldy, A., Edwards, C.A., Combet, E. (2019). The urinary phenolic acid profile varies between younger and older adults after a polyphenol-rich meal despite limited differences in in vitro colonic catabolism. European Journal of Nutrition, 58(3), 1095-1111.
  • [41] Haddadin, M., Nazer, I., Jamal, S., Raddad, A., Robinson, R. (2008). Effect of propolis on two bacterial species with probiotic potential. Pakistan Journal of Nutrition, 7(2), 391-394.
  • [42] Wang, K., Jin, X., Chen, Y., Song, Z., Jiang, X., Hu, F. (2016). Polyphenol-rich propolis extracts strengthen intestinal barrier function by activating AMP-K and ER-K signaling. Nutrients, 8(5), 272.
  • [43] Kanbur, M., Erarslan, G., Silici, S. (2009). Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotoxicology and Environmental Safety, 72(3), 909-915.
  • [44] Silva, R., Andrade, V., Rego, E., Doria, G., Lima, B., Silva, F.(2015). Acute and sub-acute oral toxicity of Brazilian red propolis in rats. Journal of Ethnopharmacology, 170, 66-71.
  • [45] Koo, H., Cury, J.A., Rosalen, P.L., Ambrosano, G.M., Ikegaki, M., Park, Y.K. (2002). Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation. Caries Research, 36(6), 445-448.
  • [46] Feres, M., Figueiredo, L.C., Barreto, I.M., Coelho, M.H., Araujo, M.W., Cortelli, S.C. (2005). In vitro antimicrobial activity of plant extracts and propolis in saliva samples of healthy and periodontally-involved subjects. Journal of the International Academy of Periodontology, 7(3), 90-96.
  • [47] Cohen, H.A., Varsano, I., Kahan, E., Sarrell, E.M., Uziel, Y. (2004). Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study. Archives of Pediatrics and Adolescent Medicine, 158(3), 217-221.
  • [48] Samadi, N., Mozaffari-Khosravi, H., Rahmanian, M., Askarishahi, M. (2017). Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: a randomized, double-blind clinical trial. Journal of Integrative Medicine, 15(2), 124-134.
  • [49] Coelho, L.G., Bastos, E.M., Resende, C.C., Paula e Silva, C.M., Fernandes Sanches, B.S., José de Castro, F., Moretzsohn, L.D., Luiz dos Santos Vieira, W., Trindade, O.R. (2007). Brazilian green propolis on Helicobacter pylori infection. a pilot clinical study. Helicobacteria, 12(5), 572-574.
  • [50] Ernst, E. (2002). Herbal medicinal products during pregnancy: are they safe? BJOG, 109(3), 227-235.11950176.
  • [51] Sawaya, A.C.F. (2009). Composition and antioxidant activity of propolis from three species of Scaptotrigona stingless bees. Journal of Apiproduct and Apimedical Science, 1(2), 37-42.
  • [52] Campos, J.F., dos Santos, U.P., Macorini, L.F., de Melo, A.M., Balestieri, J.B., Paredes-Gamero, E.J., Cardoso, C.A., de Picoli Souza, K., dos Santos, E.L. (2014). Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae). Food and Chemical Toxicology, 65, 374-380.
  • [53] Khayyal, M.T., el-Ghazaly, M.A., el-Khatib, A.S., Hatem, A.M., de Vries, P.J., el-Shafei, S., Khattab, M.M. (2003). A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Fundamental of Clinical Pharmacology, 17(1), 93-102.
  • [54] Burdock, G.A.(1998). Review of the biological properties and toxicity of bee propolis. Food Chemistry Toxicology, 36(4), 347-363.
  • [55] Barbarić, M., Mišković, K., Bojić, M. (2011). Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells. Journal of Ethnopharmacology, 135(3), 772-778.
  • [56] Abd-El-Rhman, A.M. (2009). Antagonism of Aeromonas hydrophila by propolis and its effect on the performance of Nile tilapia, Oreochromis niloticus. Fish and Shellfish Immunology, 27(3), 454-459.
  • [57] Banskota, A.H., Nagaoka, T., Sumioka, L.Y., Tezuka, Y., Awale, S., Midorikawa, K., Matsushige, K., Kadota, S. (2002). Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines. Journal of Ethnopharmacology, 80(1), 67-73.

Propolis and Effects on Human Health

Yıl 2021, Cilt: 19 Sayı: 1, 89 - 97, 26.04.2021
https://doi.org/10.24323/akademik-gida.927709

Öz

Propolis is a natural product collected by honeybees from plants, especially their flowers and buds, by mixing with wax and resin, and used for various purposes in hive. Several scientific studies have shown that propolis can be used to treat various diseases in conventional medicine since ancient times and has biological activities such as antioxidant, antimicrobial, antitumor, anti-inflammatory. Studies in the last five years have shown that phenolic compounds especially caffeic acid esters (CAPE) in propolis have high antioxidant and anti-inflammatory activity levels. Especially, some studies have demonstrated that CAPE may inhibit oxidative stress mechanisms and supress cytokine production. To ensure its effectiveness on human immune system, even though its effective intake dose is not clear, its reliable dose is 70 mg/kg, and any intake above 15 g is regarded as a toxic dose. Studies on propolis and its efficacy, side effects and reliable dose are increasing day by day, especially its effect on human immune system. In future studies, the mechanisms of its activity on immune system and more information on its effective doses are going to be significant at the level of evidence. Accordingly, it is important to define the effects of propolis on human immune system and overall health. In this study, it is aimed to summarize the studies on the properties of propolis, its consumption dose and its effects on human health.

Kaynakça

  • [1] Al-Hariri, M.T. (2011). Propolis and its direct and indirect hypoglycemic effect. Journal Family Community Medicine, 18(3), 152-154.
  • [2] Anjum, S.I., Ullah, A., Khan, K.A., Attaullah, M., Khan, H., Ali, H., Bashir, M.A., Tahir, M., Ansari, M.J., Ghramh, H.A., Adgaba, N., Dash, C.K. (2019). Composition and functional properties of propolis (bee glue): A review. Saudi Journal of Biological Sciences, 26(1), 1695-1703.
  • [3] Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., Pérez-Alvarez J.A. (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Sciences, 73(9), 117-124.
  • [4] Gómez-Caravaca, A., Gómez-Romero, M., Arráez-Román, D., Segura-Carretero, A., Fernández-Gutiérrez, A. (2006). Advances in the analysis of phenolic compounds in products derived from bees. Journal of Pharmaceutical and Biomedical Analysis, 41(4), 1220-1234.
  • [5] Huang, S., Zhang, C.-P., Wang, K., Li, G.Q., Hu, F.L. (2014). Recent advances in the chemical composition of propolis. Molecules, 19(12), 19610-19632.
  • [6] Li, A., Xuan, H., Sun, A., Liu, R., Cui, J. (2016). Preparative separation of polyphenols from water-soluble fraction of Chinese propolis using macroporous absorptive resin coupled with preparative high performance liquid chromatography. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1012-1013, 42-49.
  • [7] Türkiye Arı Yetişticileri Merkez Birliği (TAB). (2020). http://www.tab.org.tr/propolis Erişim tarihi: 24.04.2020.
  • [8] Olszewska, M. (2003). Flavonoids and their use in therapy. Farmacja Polska, 59(1), 391-402.
  • [9] Doğan, N., Hayoğlu, İ. (2012). Propolis ve kullanım alanları. Harran Üniversitesi Ziraat Fakültesi Dergisi. 16(3), 39-48.
  • [10] Park, Y.K., Alencar, S.M., Aguiar, C.L. (2002). Botanical origin and chemical composition of Brazilian propolis. Journal of Agricultural and Food Chemistry, 50(9), 2502-2506.
  • [11] Lotfy, M. (2006). Biological activity of bee propolis in health and disease. Asian Pacific Journal of Cancer Prevention, 7(1), 22-31.
  • [12] Cho, M.S., Park, W.S., Jung, W.K., Qian, Z.J., Lee, D.S., Choi, J.S., Lee, D.Y., Park, S.G., Seo, S.K., Kim, H.J., Won, J.Y., Yu, B.C., Choi, I.W. (2014). Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells. Pharmaceutical Biology, 52(7), 926-932.
  • [13] Anjaly, K., Tiku, A.B. (2018). Radio-Modulatory Potential of Caffeic Acid Phenethyl Ester: A Therapeutic Perspective. Anti-cancer Agents in Medicinal Chemistry, 18(4), 468-475.
  • [14] Volpi, N. (2004). Separation of flavonoids and phenolic acids from propolis by capillary zone electrophoresis. Electrophoresis, 25(12), 1872-1878.
  • [15] Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., Pérez-Alvarez, J.A. (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Science, 73(9), 117-124.
  • [16] Saad, M.A., Abdel Salam, R.M., Kenawy, S.A., Attia, A.S. (2015). Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion. Pharmacological Reports, 67(1), 115-122.
  • [17] Woo, K.J., Jeong, Y.J., Inoue, H., Park, J.W., Kwon, T.K. (2005). Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Letters, 579(3), 705-711.
  • [18] Choo, Y.K., Kang, H.Y., Lim, S.H. (2008). Cardiac problems in mad-honey intoxication. Circulation journal: Official Journal of the Japanese Circulation Society, 72(7), 1210-1211.
  • [19] Braakhuis, A. (2019). Evidence on the health benefits of supplemental propolis. Nutrients, 11(11), 2705.
  • [20] Matsui, T., Ebuchi, S., Fujise, T., Abesundara, K.J., Doi, S., Yamada, H., Matsumoto, K. (2004). Strong antihyperglycemic effects of watersoluble fraction of Brazilian propolis and its bioactive constituent, 3,4,5-triocaffeoylquinic acid. Biological and Pharmaceutical Bulletin, 27(11), 1797-1803.
  • [21] Afsharpour, F., Javadi, M., Hashemipour, S., Koushan, Y.,Haghighian, H.K. (2019). Propolis supplementation improves glycemic and antioxidant status in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study. Complementary Therapies in Medicine, 43, 283-288.
  • [22] Kang, L.J., Lee, H.B., Bae, H.J., Lee, S.G. (2010). Antidiabetic effect of propolis: reduction of expression of glucose-6-phosphatase through inhibition of Y279 and Y216 autophosphorylation of GSK-3α/β in HepG2 cells. Phytotherapy Research, 24(1),1554-1561.
  • [23] Okutan, H., Ozcelik, N., Yilmaz, H.R., Uz, E. (2005). Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart. Clinical Biochemistry, 38(2), 191-196.
  • [24] Lee K.W., Chun K.S., Lee J.S., Kang K.S., Surh Y.J., Lee H.J. (2004). Inhibition of cyclooxygenase‐2 expression and restoration of gap junction intercellular communication in H‐ras‐transformed rat liver epithelial cells by caffeic acid phenethyl ester. Annal of New York Academy Science, 1030, 501-507.
  • [25] Cho, M.J., Howard, L.R., Prior, R.L., Clark, J.R. (2004). Flavonoid glycosides and antioxidant capacity of varous blackberry, blueberry and red grape genotypes determined by high-performance liquid chromatography/mass spectrometry. Journal of the Science of Food and Agriculture, 84(13), 771-1782.
  • [26] Fuliang, H., Hepburn, H.R., Xuan, H., Chen, M., Daya, S., Radloff, S.E. (2005). Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacological Research, 51(2), 147-152.
  • [27] Kwon, Y.S., Park, D.H., Shin, E.J., Kwon, M.S., Ko, K.H., Kim, W.K., Jhoo, J.H., Jhoo, W.K., Wie, M.B., Jung, B.D., Kim, H.C. (2004). Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat. Neuroscience Letters, 355(3), 231-235.
  • [28] Meng, F., Liu, R., Gao, M., Wang, Y., Yu, X., Xuan, Z., Sun, J., Yang, F., Wu, C., Du, G. (2011). Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats. Brain Research, 1391, 93-101.
  • [29] Liu, R., Li, J.Z., Song, J.K., Zhou, D., Huang, C., Bai, X.Y., Xie, T., Zhang, X., Li, Y.J., Wu, C.X., Zhang, L., Li, L., Zhang, T.T., Du, G.H. (2014). Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits. Neurobiology of Aging, 35(6),1275-1285.
  • [30] Alkis, H.E., Kuzhan, A., Dirier, A.,Tarakcioglu, M., Demir, E., Saricicek, E.,Demir, T., Ahlatci,A., Demirci, A.,Cinar, K. (2015). Neuroprotective effects of propolis and caffeic acid phenethyl ester (CAPE) on the radiation-injured brain tissue. International Journal of Radiation Research, 13(4), 297-303.
  • [31] AL-Waili, N., Al Ghamdi, A., Ansari, M.J., Al-Attal, Y., Al-Mubarak, A., Salom, K. (2013). Differences in composition of honey samples and their impact on the antimicrobial activities against drug multiresistant bacteria and pathogenic fungi. Archives of Medical Research, 44(4), 307-316.
  • [32] Gao, W., Wu, J., Wei, J., Pu, L., Guo, C., Yang, J., Yang, M., Luo, H. (2014). Brazilian green propolis improves immune function in aged mice. Journal of Clinical Biochemistry and Nutrition, 55(1), 7-10.
  • [33] Nakajima, Y., Shimazawa, M., Mishima, S., Hara, H. (2009). Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis. Phytotherapy Research, 23(10), 1431-1438.
  • [34] Braakhuis A. (2019). Evidence on the health benefits of supplemental propolis. Nutrients, 11(11), 2705.
  • [35] Batista, L.L.V., Campesatto, E.A., Assis, M.L.B., Barbosa, A.P.F., Grillo, L.A.M., Dornelas, C.B. (2012). Comparative study of topical green and red propolis in the repair of wounds induced in rats. Journal of the Brazilian College of Surgeons, 39(6), 515-520.
  • [36] Baktır, G. (2011). Yara iyileşmesi ve deneysel yara modelleri. Experimed, 9(3), 130-137.
  • [37] Stewart, J.A., McGrane, O.L., Wedmore, I.S. (2014). Wound care in the wilderness: is there evidence for honey? Wilderness Environmental Medicine, 25(1), 103-110.
  • [38] Tolba, M.F., Azab, S.S., Khalifa, A. E., Abdel-Rahman, S.Z., Abdel-Naim, A.B. (2013). Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: a review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects. IUBMB Life, 65(8), 699-709.
  • [39] Swamy, M., Suhaili, D., Sirajudeen, K.N., Mustapha, Z., Govindasamy, C. (2014). Propolis ameliorates tumor nerosis factor-α, nitric oxide levels, caspase-3 and nitric oxide synthase activities in kainic acid mediated excitotoxicity in rat brain. African Journal of Traditional, Complementary, and Alternative Medicines, 11(5), 48-53.
  • [40] Alkhaldy, A., Edwards, C.A., Combet, E. (2019). The urinary phenolic acid profile varies between younger and older adults after a polyphenol-rich meal despite limited differences in in vitro colonic catabolism. European Journal of Nutrition, 58(3), 1095-1111.
  • [41] Haddadin, M., Nazer, I., Jamal, S., Raddad, A., Robinson, R. (2008). Effect of propolis on two bacterial species with probiotic potential. Pakistan Journal of Nutrition, 7(2), 391-394.
  • [42] Wang, K., Jin, X., Chen, Y., Song, Z., Jiang, X., Hu, F. (2016). Polyphenol-rich propolis extracts strengthen intestinal barrier function by activating AMP-K and ER-K signaling. Nutrients, 8(5), 272.
  • [43] Kanbur, M., Erarslan, G., Silici, S. (2009). Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotoxicology and Environmental Safety, 72(3), 909-915.
  • [44] Silva, R., Andrade, V., Rego, E., Doria, G., Lima, B., Silva, F.(2015). Acute and sub-acute oral toxicity of Brazilian red propolis in rats. Journal of Ethnopharmacology, 170, 66-71.
  • [45] Koo, H., Cury, J.A., Rosalen, P.L., Ambrosano, G.M., Ikegaki, M., Park, Y.K. (2002). Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation. Caries Research, 36(6), 445-448.
  • [46] Feres, M., Figueiredo, L.C., Barreto, I.M., Coelho, M.H., Araujo, M.W., Cortelli, S.C. (2005). In vitro antimicrobial activity of plant extracts and propolis in saliva samples of healthy and periodontally-involved subjects. Journal of the International Academy of Periodontology, 7(3), 90-96.
  • [47] Cohen, H.A., Varsano, I., Kahan, E., Sarrell, E.M., Uziel, Y. (2004). Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study. Archives of Pediatrics and Adolescent Medicine, 158(3), 217-221.
  • [48] Samadi, N., Mozaffari-Khosravi, H., Rahmanian, M., Askarishahi, M. (2017). Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: a randomized, double-blind clinical trial. Journal of Integrative Medicine, 15(2), 124-134.
  • [49] Coelho, L.G., Bastos, E.M., Resende, C.C., Paula e Silva, C.M., Fernandes Sanches, B.S., José de Castro, F., Moretzsohn, L.D., Luiz dos Santos Vieira, W., Trindade, O.R. (2007). Brazilian green propolis on Helicobacter pylori infection. a pilot clinical study. Helicobacteria, 12(5), 572-574.
  • [50] Ernst, E. (2002). Herbal medicinal products during pregnancy: are they safe? BJOG, 109(3), 227-235.11950176.
  • [51] Sawaya, A.C.F. (2009). Composition and antioxidant activity of propolis from three species of Scaptotrigona stingless bees. Journal of Apiproduct and Apimedical Science, 1(2), 37-42.
  • [52] Campos, J.F., dos Santos, U.P., Macorini, L.F., de Melo, A.M., Balestieri, J.B., Paredes-Gamero, E.J., Cardoso, C.A., de Picoli Souza, K., dos Santos, E.L. (2014). Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae). Food and Chemical Toxicology, 65, 374-380.
  • [53] Khayyal, M.T., el-Ghazaly, M.A., el-Khatib, A.S., Hatem, A.M., de Vries, P.J., el-Shafei, S., Khattab, M.M. (2003). A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Fundamental of Clinical Pharmacology, 17(1), 93-102.
  • [54] Burdock, G.A.(1998). Review of the biological properties and toxicity of bee propolis. Food Chemistry Toxicology, 36(4), 347-363.
  • [55] Barbarić, M., Mišković, K., Bojić, M. (2011). Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells. Journal of Ethnopharmacology, 135(3), 772-778.
  • [56] Abd-El-Rhman, A.M. (2009). Antagonism of Aeromonas hydrophila by propolis and its effect on the performance of Nile tilapia, Oreochromis niloticus. Fish and Shellfish Immunology, 27(3), 454-459.
  • [57] Banskota, A.H., Nagaoka, T., Sumioka, L.Y., Tezuka, Y., Awale, S., Midorikawa, K., Matsushige, K., Kadota, S. (2002). Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines. Journal of Ethnopharmacology, 80(1), 67-73.
Toplam 57 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Gıda Mühendisliği
Bölüm Derleme Makaleler
Yazarlar

Aylin Seylam Küşümler Bu kişi benim 0000-0003-4705-8042

Ayça Çelebi Bu kişi benim 0000-0001-9955-6997

Yayımlanma Tarihi 26 Nisan 2021
Gönderilme Tarihi 18 Haziran 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 19 Sayı: 1

Kaynak Göster

APA Seylam Küşümler, A., & Çelebi, A. (2021). Propolis ve Sağlık Üzerine Etkileri. Akademik Gıda, 19(1), 89-97. https://doi.org/10.24323/akademik-gida.927709
AMA Seylam Küşümler A, Çelebi A. Propolis ve Sağlık Üzerine Etkileri. Akademik Gıda. Nisan 2021;19(1):89-97. doi:10.24323/akademik-gida.927709
Chicago Seylam Küşümler, Aylin, ve Ayça Çelebi. “Propolis Ve Sağlık Üzerine Etkileri”. Akademik Gıda 19, sy. 1 (Nisan 2021): 89-97. https://doi.org/10.24323/akademik-gida.927709.
EndNote Seylam Küşümler A, Çelebi A (01 Nisan 2021) Propolis ve Sağlık Üzerine Etkileri. Akademik Gıda 19 1 89–97.
IEEE A. Seylam Küşümler ve A. Çelebi, “Propolis ve Sağlık Üzerine Etkileri”, Akademik Gıda, c. 19, sy. 1, ss. 89–97, 2021, doi: 10.24323/akademik-gida.927709.
ISNAD Seylam Küşümler, Aylin - Çelebi, Ayça. “Propolis Ve Sağlık Üzerine Etkileri”. Akademik Gıda 19/1 (Nisan 2021), 89-97. https://doi.org/10.24323/akademik-gida.927709.
JAMA Seylam Küşümler A, Çelebi A. Propolis ve Sağlık Üzerine Etkileri. Akademik Gıda. 2021;19:89–97.
MLA Seylam Küşümler, Aylin ve Ayça Çelebi. “Propolis Ve Sağlık Üzerine Etkileri”. Akademik Gıda, c. 19, sy. 1, 2021, ss. 89-97, doi:10.24323/akademik-gida.927709.
Vancouver Seylam Küşümler A, Çelebi A. Propolis ve Sağlık Üzerine Etkileri. Akademik Gıda. 2021;19(1):89-97.

25964   25965    25966      25968   25967


88x31.png

Bu eser Creative Commons Atıf-GayriTicari 4.0 (CC BY-NC 4.0) Uluslararası Lisansı ile lisanslanmıştır.

Akademik Gıda (Academic Food Journal) is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).