Akdeniz Üniversitesi Hastanesinde 2014-2018 Yılları Arasındaki Selektif Serotonin Gerialım İnhibitörleri/Serotonin ve Noradrenalin Gerialım İnhibitörleri Reçetelerinin Retrospektif Olarak Değerlendirilmesi

Öz

Amaç: Bu çalışma, Akdeniz Üniversitesi Hastanesinde 2014-2018 yılları arasında yazılan selektif serotonin gerialım inhibitörleri SSGİ / serotonin ve noradrenalin gerialım inhibitörleri SNGİ reçetelerindeki yıllar, yaş grupları, cinsiyet ve anabilim dalları arasındaki değişimleri karşılaştırmak amacıyla yapılmıştır. Gereç ve Yöntemler: 2014-2018 yılları arasında yazılan e-reçete verileri tanımlayıcı istatistik yöntemleri kullanılarak analiz edilmiştir. Bulgular: 2014-2018 yılları arasında yazılan SSGİ/SNGİ e-reçete sayılarının yıllar içerisinde arttığı, en sık olarak sertralin en az olarak duloksetin reçete edildiği görülmüştür. Ayrıca yıllara, yaş gruplarına ve anabilim dallarına göre SSGİ/SNGİ reçete edilme oranlarının değiştiği görülmüştür. Sonuç: Bilgilerimize göre çalışmamız ülkemizde bir üniversite hastanesinde SSGİ/SNGİ grubunda yer alan antidepresan reçetelerinin retrospektif olarak değerlendirildiği ilk çalışmadır. MİA-Med ve benzeri bilgi sistemlerinin kullanılması ve bu sistemlerde bulunan elektronik verilerin genişletilmesi retrospektif çalışmaların yapılabilirliğini artıracaktır

Anahtar Kelimeler

• Antidepresan, Reçete, Retrospektif

Retrospective Evaluation of Selective Serotonin Reuptake Inhibitor/ Serotonin Noradrenaline Reuptake Inhibitor Prescriptions Between 2014 and 2018 at Akdeniz University Hospital

Abstract

Objective: The aim of this study was to compare the changes between the years, age groups, gender and departments of the prescriptions of the selective serotonin reuptake inhibitors SSRI and the serotonin and noradrenaline reuptake inhibitors SNGI between 2014 and 2018 at Akdeniz University Hospital.Material and Methods: E-prescription data recorded between 2014 and 2018 were analyzed using descriptive statistical methods. Results: It was observed that the number of SSRI / SNGI e-prescriptions recorded between 20142018 increased over the years; sertraline was the most frequently and duloxetine was the least frequently prescribed. In addition, SSRI / SNGI prescription rates varied by year, age group and department. Conclusion: To our knowledge, this is the first study that retrospectively evaluated antidepressant

Keywords

• Antidepressant, Prescription, Retrospective

Kaynakça

1. Hemels ME, Koren G, Einarson TR. Increased use of antidepressants in Canada: 1981-2000. Ann Pharmacother 2002; 36:1375-9.
2. Kantor ED, Rehm CD, Haas JS, Chan AT, Giovannucci EL. Trends in prescription drug use among adults in the United States from 1999-2012. JAMA 2015; 314:1818- 31.
3. Mars B, Heron J, Kessler D, Davies NM, Martin RM, Thomas KH, Gunnell D. Influences on antidepressant prescribing trends in the UK: 1995-2011. Soc Psychiatry Psychiatr Epidemiol 2017; 52:193-200.
4. Meijer WE, Heerdink ER, Leufkens HG, Herings RM, Egberts AC, Nolen WA. Incidence and determinants of long-term use of antidepressants. Eur J Clin Pharmacol 2004; 60(1):57-61.
5. Sonnenberg CM, Deeg DJ, Comijs HC, van Tilburg W, Beekman AT. Trends in antidepressant use in the older population: Results from the LASA-study over a period of 10 years. J Affect Disord 2008; 111:299-305.
6. Mojtabai R, Olfson M. National trends in long-term use of antidepressant medications: Results from the U.S. National Health and Nutrition Examination Survey. J Clin Psychiatry 2014; 75:169-77.
7. Wang YY, Xiang YT, Ungvari GS, Ng CH, Chiu HFK, Yim LCL, Si TM, Chee KY, Avasthi A, Grover S, Chong MY, Sim K, Kanba S, He YL, Lee MS, Yang SY, Udomratn P, Kallivayalil RA, Tanra AJ, Maramis MM, Shen WW, Sartorius N, Mahendran R, Teng JY, Tan CH, Shinfuku N. A comparison of clinical characteristics of older adults treated with antidepressants in general and psychiatric hospitals in Asia. Psychogeriatrics 2017; 17:348-55.
8. Economic crisis and mental health in Spain. Lancet 2013; 382:1977-8.

9. Sheldon T. Reserve antidepressants for cases of severe depression, Dutch doctors are told. BMJ 2012; 344:e4211.
10. Forns J, Pottegård A, Reinders T, Poblador-Plou B, Morros R, Brandt L, Cainzos-Achirica M, Hellfritzsch M, Schink T, Prados-Torres A, Giner-Soriano M, Hägg D, Hallas J, Cortés J, Jacquot E, Deltour N, Perez- Gutthann S, Pladevall M, Reutfors J. Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators. J Affect Disord 2019; 249:242-52.
11. Poluzzi E, Piccinni C, Sangiorgi E, Clo M, Tarricone I, Menchetti M, De Ponti F. Trend in SSRI-SNRI antidepressants prescription over a 6-year period and predictors of poor adherence. Eur J Clin Pharmacol 2013; 69:2095-101.
12. Aguglia E, Ravasio R, Simonetti M, Pecchioli S, Mazzoleni F. Use and treatment modalities for SSRI and SNRI antidepressants in Italy during the period 2003- 2009. Curr Med Res Opin 2012; 28:1475-84.
13. Chee KY, Tripathi A, Avasthi A, Chong MY, Sim K, Yang SY, Glover S, Xiang YT, Si TM, Kanba S, He YL, Lee MS, Chiu HF, Kuga H, Mahendran R, Udormatn P, Kallivayalil RA, Tanra AJ, Maramis M, Shinfuku N, Shen WW, Tan CH, Sartorius N. International study on antidepressant prescription pattern at 40 major psychiatric institutions and hospitals in Asia: A 10-year comparison study. Asia Pac Psychiatry 2015; 7:366-74.
14. Faquih AE, Memon RI, Hafeez H, Zeshan M, Naveed S. A Review of Novel Antidepressants: A Guide for Clinicians. Cureus 2019; 11:e4185.
15. Haller E, Watzke B, Blozik E, Rosemann T, Reich O, Huber CA, Wolf M. Antidepressant prescription practice and related factors in Switzerland: A cross-sectional analysis of health claims data. BMC Psychiatry 2019; 19:196.
16. Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Lancet 2018; 391:1357-66.