Association Of ABO And Rh Blood Groups And COVID-19 Susceptibility And Disease Severity İn Turkish Population – A Retrospective Case-Control Study

Yıl 2022, , 257 - 262, 01.09.2022

Faruk Karandere , Hakan Kocoglu Ramazan Korkusuz , Betül Erismis Mehmet Hursitoglu Kadriye Kart Yasar

https://doi.org/10.53394/akd.1060576

Öz

Abstract
Objective: To determine whether there is a difference in the frequency of blood groups between the general population and COVID –19 patients and whether there is a relationship between blood groups and mortality and severity of chest CT involvement at admission in COVID –19 patients.
Materials and Methods: 1546 COVID –19 patients were evaluated. Clinical data including age, sex, comorbidities, complaints at the time of admission, and outcome of the patients were obtained from medical records. In order to determine the normal distribution of the blood groups in the general population, a previous study conducted on Turkish population which consisted of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group.
Results: There was no significant difference in gender, CT results, duration of hospitalization, and mortality rates between the blood groups (p >0.05 for all). When we compared the frequency of blood groups between the population and the patients, a statistically significant difference was found in regard to the A Rh + blood group rates (p = 0.026). Also in our study, the rate of A Rh + was found to be higher in hospitalized COVID –19 patients than the population. Also, the frequency of A Rh+ blood group was higher in patients with severe chest CT involvement compared to the normal population (p = 0.007).

Conclusion: No significant difference was found between the blood groups and gender, severity of CT findings, duration of hospitalization, and mortality rates. But the rate of A Rh + was detected to be significantly higher in hospitalized COVID –19 patients than the population. Also, patients who had severe chest CT findings had higher frequency of A Rh+ blood group when compared to the normal population.
Keywords: ABO blood groups, Rh groups, COVID-19, Mortality, SARS-CoV-2

Anahtar Kelimeler

ABO blood groups, Rh groups, COVID-19, Mortality, SARS-CoV-2

Türk Popülasyonunda ABO ve Rh Kan Grupları ve COVID-19 Duyarlılığı ve Hastalık Şiddeti İlişkisi - Retrospektif Bir Vaka Kontrol Çalışması

Öz

Öz
Amaç: COVID-19 hastalarında genel popülasyon ile COVID-19 hastaları arasında kan gruplarının sıklığında bir fark olup olmadığını ve kan grupları ile mortalite ve göğüs BT tutulumunun şiddeti arasında bir ilişki olup olmadığını belirlemek.
Gereç ve Yöntem: 1546 COVID-19 hasta değerlendirildi. Hastaların yaş, cinsiyet, ek hastalıklar, başvuru sırasındaki şikayetleri ve sonuçları gibi klinik veriler tıbbi kayıtlardan elde edildi. Genel popülasyondaki kan gruplarının normal dağılımını belirlemek amacıyla Türk popülasyonu üzerinde yapılan ve Türk Kızılayı'nın 3.022.883 sağlıklı kan donöründen oluşan önceki bir çalışma kontrol grubu olarak belirlenmiştir.
Bulgular: Kan grupları arasında cinsiyet, BT sonuçları, hastanede kalış süresi ve ölüm oranları açısından anlamlı fark yoktu (tümü için p>0,05). Popülasyondaki kan gruplarının sıklığı ve hastalar karşılaştırıldığında, A Rh + kan grubu oranları açısından istatistiksel olarak anlamlı bir fark bulundu (p=0,026). Çalışmamızda hastanede yatan COVID-19 hastalarında A Rh + oranı popülasyona göre daha yüksek bulunmuştur. Ayrıca, ciddi göğüs BT tutulumu olan hastalarda A Rh + kan grubu sıklığı normal popülasyona göre daha yüksekti (p=0,007).
Sonuç: Kan grupları ile cinsiyet, BT bulgularının şiddeti, hastanede kalış süresi ve ölüm oranları arasında anlamlı bir fark bulunmadı. Ancak hastanede yatan COVID-19 hastalarında A Rh + oranının popülasyona göre önemli ölçüde daha yüksek olduğu tespit edildi. Ayrıca, ciddi göğüs BT bulguları olan hastalarda, normal popülasyona göre daha yüksek sıklıkta A Rh + kan grubu vardı.
Anahtar Sözcükler: ABO kan grupları, Rh grupları, COVID-19, Mortalite, SARS-CoV2

Anahtar Kelimeler

BO kan grupları, Rh grupları, COVID-19, Mortalite, SARS-CoV2

Kaynakça

• 1. World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard. available at: https://covid19.who.int/. Accessed December 1, 2020
• 2. Zheng, Z., Peng, F., Xu, B., Zhao, J., Liu, H., Peng, J., Li, Q., Jiang, C., Zhou, Y., Liu, S., Ye, C., Zhang, P., Xing, Y., Guo, H., & Tang, W. (2020). Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. The Journal of infection, 81(2), e16–e25. https://doi.org/10.1016/j.jinf.2020.04.021
• 3. Miyoshi M, Yoshizumi S, Sato C, Okui T, Ogawa H, Honma H. [Relationship between ABO histo-blood group type and an outbreak of norovirus gastroenteritis among primary and junior high school students: results of questionnaire-based study]. Kansenshogaku Zasshi. 2005 Sep;79(9):664-71. Japanese. doi: 10.11150/kansenshogakuzasshi1970.79.664. PMID: 16248375.
• 4. Batool Z, Durrani SH, Tariq S. Association Of ABO And Rh Blood Group Types To Hepatitis B, Hepatitis C, Hiv And Syphilis Infection, A Five Year' Experience In Healthy Blood Donors In A Tertiary Care Hospital. J Ayub Med Coll Abbottabad. 2017 Jan-Mar;29(1):90-92. PMID: 28712183.
• 5. Cheng Y, Cheng G, Chui CH, Lau FY, Chan PK, Ng MH, Sung JJ, Wong RS. ABO blood group and susceptibility to severe acute respiratory syndrome. JAMA. 2005 Mar 23;293(12):1450-1. doi: 10.1001/jama.293.12.1450-c. Erratum in: JAMA. 2005 Aug 17;294(7):794. Cheng, Yufeng [corrected to Cheng, Yunfeng]. PMID: 15784866.
• 6. Varughese S, Read JG, Al-Khal A, Abo Salah S, El Deeb Y, Cameron PA. Effectiveness of the Middle East respiratory syndrome-coronavirus protocol in enhancing the function of an Emergency Department in Qatar. Eur J Emerg Med. 2015 Oct;22(5):316-20. doi: 10.1097/MEJ.0000000000000285. PMID: 26035278; PMCID: PMC5747930.
• 7.Dzik S, Eliason K, Morris EB, Kaufman RM, North CM. COVID-19 and ABO blood groups. Transfusion. 2020;60(8):1883-1884. doi:10.1111/trf.15946
• 8. Göker H, Aladağ Karakulak E, Demiroğlu H, Ayaz Ceylan ÇM, Büyükaşik Y, Inkaya AÇ, Aksu S, Sayinalp N, Haznedaroğlu IC, Uzun Ö, Akova M, Özcebe OI, Ünal S. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turk J Med Sci. 2020 Jun 23;50(4):679-683. doi: 10.3906/sag-2005-395. PMID: 32496734; PMCID: PMC7379446.
• 9.Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta. 2020 Oct;509:220-223. doi: 10.1016/j.cca.2020.06.026. Epub 2020 Jun 17. PMID: 32562665; PMCID: PMC7832938.
• 10. Urun Y, Utkan G, Cangir AK, Oksuzoglu OB, Ozdemir N, Oztuna DG, et al. Association of ABO blood group and risk of lung cancer in a multicenter study in Turkey. Asian Pac J Cancer Prev. 2013;14(5):2801-3. doi: 10.7314/apjcp.2013.14.5.2801. PMID: 23803034.
• 11. Zhao, J., Yang, Y., Huang, H., Li, D., Gu, D., Lu, X., Zhang, Z., Liu, L., Liu, T., Liu, Y., He, Y., Sun, B., Wei, M., Yang, G., Wang, X., Zhang, L., Zhou, X., Xing, M., & Wang, P. G. (2020). Relationship between the ABO Blood Group and the COVID-19 Susceptibility. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ciaa1150. Advance online publication. https://doi.org/10.1093/cid/ciaa1150
• 12. Zietz, M., Zucker, J. & Tatonetti, N.P. Associations between blood type and COVID-19 infection, intubation, and death. Nat Commun 11, 5761 (2020). https://doi.org/10.1038/s41467-020-19623-x
• 13.Xianfei Zeng, Hongyan Fan, Dongxue Lu, Fang Huang, Xi Meng, Zhuo Li, Mei Tang, Jing Zhang, Nannan Liu, Zhixin Liu, Jingya Zhao, Wen Yin, Qunxing An, Xijing Zhang, Xingbin Hu. Association between ABO blood groups and clinical outcome of coronavirus disease 2019: Evidence from two cohorts. medRxiv. April 17,2020.doi:10.1101/2020.04.15.20063107
• 14. Latz CA, DeCarlo C, Boitano L, Png CYM, Patell R, Conrad MF, Eagleton M, Dua A. Blood type and outcomes in patients with COVID-19. Ann Hematol. 2020 Sep;99(9):2113-2118. doi: 10.1007/s00277-020-04169-1. Epub 2020 Jul 12. PMID: 32656591; PMCID: PMC7354354.
• 15. Severe Covid-19 GWAS Group. Genomewide Association Study of Severe Covid-19 with Respiratory Failure. N Engl J Med. 2020 Oct 15;383(16):1522-1534. doi: 10.1056/NEJMoa2020283. Epub 2020 Jun 17. PMID: 32558485; PMCID: PMC7315890.
• 16. E Arac, I Solmaz, H Akkoc, S Donmezdıl, Z Karahan, S Kaya, Y Mertsoy, M S Yıldırım, N Ekın, S Arac, C Demır. Association Between the Rh Blood Group and the Covid-19 Susceptibility.UHOD, 2020; 30:081-086.
• 17. Guillon P, Clément M, Sébille V, Rivain JG, Chou CF, Ruvoën-Clouet N, Le Pendu J. Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology. 2008 Dec;18(12):1085-93. doi: 10.1093/glycob/cwn093. Epub 2008 Sep 25. PMID: 18818423; PMCID: PMC7108609.