The Role of Vitamin D Supplementation Program on Fertility Outcomes in Women with Embryo Transfers

Abstract

Objective: This study aimed to determine the effect of vitamin D supplementation given to women undergoing embryo transfer on pregnancy outcomes. Materials and Methods: This study was conducted experimentally in a pre-test-post-test design. The sample of the study consisted of a total of 118 women, with 58 in the intervention group and 60 in the control group. While the vitamin D supplementation program was administered to women in the intervention group at the beginning of infertility treatment, women in the control group did not receive a vitamin D supplementation program. At the end of the study, pregnancy and clinical pregnancy rates of women in the intervention and control groups, as well as their serum 25(OH) D levels, were examined. Results: The vitamin D level of women in the intervention group at the beginning of treatment (12.47±6.03 ng/mL) was statistically significantly lower than the vitamin D level on the day of beta-hCG (32.34±9.62 ng/mL) (p=0.000). The mean vitamin D level of the women in the control group (14.30±7.03 ng/mL) on the day of beta-hCG was statistically significantly lower than that of the women in the intervention group (32.34±9.62 ng/mL) (p=0.000). While there was no statistically significant difference in the pregnancy rates of women in the intervention and control groups, a statistically significant difference was found in the clinical pregnancy rates (respectively, p=0.066 and p=0.014). Conclusion: This study demonstrated that vitamin D supplementation program for women undergoing infertility treatment with deficient or insufficient vitamin D levels may increase vitamin D levels and clinical pregnancy rate after embryo transfer.

Keywords

• Embryo transfer
• infertility
• pregnancy rate
• Turkey
• vitamin D deficiency

Embriyo Transferi Yapılan Kadınlarda D Vitamini Destek Programının Doğurganlık Sonuçları Üzerindeki Rolü

Öz

Amaç: Bu çalışma embriyo transferi yapılan kadınlara verilen D vitamini desteğinin, gebelik sonuçları üzerindeki etkisini belirlemeyi amaçlamaktadır. Gereç ve Yöntemler: Bu çalışma ön test-son test düzeninde deneysel olarak yürütülmüştür. Çalışmanın örneklemi 58’i girişim, 60’ı kontrol grubunda olmak üzere toplam 118 kadından oluşmaktadır. Girişim grubundaki kadınlara infertilite tedavisinin başlangıcında D vitamini destek programı uygulanırken, kontrol grubundaki kadınlara D vitamini destek programı uygulanmamıştır. Çalışmanın sonunda, girişim ve kontrol grubundaki kadınların gebelik ve klinik gebelik oranları ve kanda 25(OH)D düzeyleri incelenmiştir. Bulgular: Girişim grubundaki kadınların tedavi başlangıcındaki D vitamini düzeyi (12,47±6,03 ng/mL), beta-hCG günü bakılan D vitamin düzeyinden (32,34±9,62 ng/mL) istatistiksel olarak anlamlı düzeyde daha düşüktür (p=0,000). Kontrol grubundaki kadınların beta-hCG günü bakılan D vitamini düzeyi (14,30±7,03 ng/mL), girişim grubundaki kadınlardan (32,34±9,62 ng/mL) istatistiksel olarak anlamlı derecede daha düşüktür (p=0,000). Girişim ve kontrol grubundaki kadınların gebelik oranlarında istatistiksel olarak anlamlı bir fark bulunmazken, klinik gebelik oranlarında istatistiksel olarak anlamlı bir fark bulunmuştur (p=0,066, p=0,014 sırasıyla). Sonuç: Bu çalışma, infertilite tedavisi gören ve D vitamini düzeyi eksik ya da yetersiz olan kadınlara yönelik D vitamini destek programının, kadınların D vitamini düzeylerini ve embriyo transferi sonrası klinik gebelik oranlarını artırabileceğini göstermiştir.

Anahtar Kelimeler

• Embriyo Transferi
• infertilite
• gebelik oranı
• Türkiye
• D vitamini eksikliği

Kaynakça

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