The Role of Vitamin D Supplementation Program on Fertility Outcomes in Women with Embryo Transfers

Öz

Objective: This study aimed to determine the effect of vitamin D supplementation given to women undergoing embryo transfer on pregnancy outcomes. Materials and Methods: This study was conducted experimentally in a pre-test-post-test design. The sample of the study consisted of a total of 118 women, with 58 in the intervention group and 60 in the control group. While the vitamin D supplementation program was administered to women in the intervention group at the beginning of infertility treatment, women in the control group did not receive a vitamin D supplementation program. At the end of the study, pregnancy and clinical pregnancy rates of women in the intervention and control groups, as well as their serum 25(OH) D levels, were examined. Results: The vitamin D level of women in the intervention group at the beginning of treatment (12.47±6.03 ng/mL) was statistically significantly lower than the vitamin D level on the day of beta-hCG (32.34±9.62 ng/mL) (p=0.000). The mean vitamin D level of the women in the control group (14.30±7.03 ng/mL) on the day of beta-hCG was statistically significantly lower than that of the women in the intervention group (32.34±9.62 ng/mL) (p=0.000). While there was no statistically significant difference in the pregnancy rates of women in the intervention and control groups, a statistically significant difference was found in the clinical pregnancy rates (respectively, p=0.066 and p=0.014). Conclusion: This study demonstrated that vitamin D supplementation program for women undergoing infertility treatment with deficient or insufficient vitamin D levels may increase vitamin D levels and clinical pregnancy rate after embryo transfer.

Anahtar Kelimeler

• Embryo transfer
• infertility
• pregnancy rate
• Turkey
• vitamin D deficiency

Proje Numarası

Project No: TSA-2015-409

Embriyo Transferi Yapılan Kadınlarda D Vitamini Destek Programının Doğurganlık Sonuçları Üzerindeki Rolü

Öz

Amaç: Bu çalışma embriyo transferi yapılan kadınlara verilen D vitamini desteğinin, gebelik sonuçları üzerindeki etkisini belirlemeyi amaçlamaktadır. Gereç ve Yöntemler: Bu çalışma ön test-son test düzeninde deneysel olarak yürütülmüştür. Çalışmanın örneklemi 58’i girişim, 60’ı kontrol grubunda olmak üzere toplam 118 kadından oluşmaktadır. Girişim grubundaki kadınlara infertilite tedavisinin başlangıcında D vitamini destek programı uygulanırken, kontrol grubundaki kadınlara D vitamini destek programı uygulanmamıştır. Çalışmanın sonunda, girişim ve kontrol grubundaki kadınların gebelik ve klinik gebelik oranları ve kanda 25(OH)D düzeyleri incelenmiştir. Bulgular: Girişim grubundaki kadınların tedavi başlangıcındaki D vitamini düzeyi (12,47±6,03 ng/mL), beta-hCG günü bakılan D vitamin düzeyinden (32,34±9,62 ng/mL) istatistiksel olarak anlamlı düzeyde daha düşüktür (p=0,000). Kontrol grubundaki kadınların beta-hCG günü bakılan D vitamini düzeyi (14,30±7,03 ng/mL), girişim grubundaki kadınlardan (32,34±9,62 ng/mL) istatistiksel olarak anlamlı derecede daha düşüktür (p=0,000). Girişim ve kontrol grubundaki kadınların gebelik oranlarında istatistiksel olarak anlamlı bir fark bulunmazken, klinik gebelik oranlarında istatistiksel olarak anlamlı bir fark bulunmuştur (p=0,066, p=0,014 sırasıyla). Sonuç: Bu çalışma, infertilite tedavisi gören ve D vitamini düzeyi eksik ya da yetersiz olan kadınlara yönelik D vitamini destek programının, kadınların D vitamini düzeylerini ve embriyo transferi sonrası klinik gebelik oranlarını artırabileceğini göstermiştir.

Anahtar Kelimeler

• Embriyo Transferi
• infertilite
• gebelik oranı
• Türkiye
• D vitamini eksikliği

Destekleyen Kurum

This study was supported by the Akdeniz University Scientific Research Project Management Unit (Project No: TSA-2015-409).

Proje Numarası

Project No: TSA-2015-409

Etik Beyan

Ethics approval was obtained from the Turkish Ministry of Health, Turkish Pharmaceuticals, and the Medical Devices Agency Clinical Studies Ethical Board. The study authors reviewed written consent forms with the participants, who were allowed to read the consent forms independently and ask questions before signing them.

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